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77 Possible Causes for Cholelithiasis, Congenital Nonspherocytic Hemolytic Anemia

  • Hereditary Spherocytosis

    This is a report of an 11 years old male diagnosed case of hereditary spherocytosis who presented with jaundice, splenomegaly and cholelithiasis.[ncbi.nlm.nih.gov] In this paper we describe how we perform laparoscopic splenectomy plus cholecystectomy at the same time to treat hereditary spherocytosis combined with cholelithiasis in two[ncbi.nlm.nih.gov] The patient presented with cholelithiasis and hyperbilirubinemia. He had no anemia and was asymptomatic with mild splenomegaly.[ncbi.nlm.nih.gov]

  • Pyruvate Kinase Deficiency

    […] laparoscopic splenectomy and cholecystectomy is safe and effective for the management of hemolytic anemia resulting from pyruvatre kinase deficiency and associated with cholelithiasis[ncbi.nlm.nih.gov] In this later group of "congenital nonspherocytic hemolytic anemias" splenectomy has often been performed but usually does not produce a clinical cure.[nejm.org] […] acquired blood disorder Iron overload sufficiently severe to result in cardiac, hepatic or pancreatic insufficiency Bone marrow or stem cell transplant Clinically symptomatic cholelithiasis[clinicaltrials.gov]

  • Congenital Hemolytic Anemia

    Early phenobarbital treatment may prevent the development of cholelithiasis in patients with chronic hemolysis.[ncbi.nlm.nih.gov] This group is sometimes called congenital nonspherocytic (hemolytic) anemia, which is a term for a congenital hemolytic anemia without spherocytosis, and usually excluding[en.wikipedia.org] The clinical manifestations of congenital hemolytic anemia are anemia, jaundice, cholelithiasis and splenomegaly, while the onset mode and severity are both variable.[ncbi.nlm.nih.gov]

  • Autoimmune Hemolytic Anemia

    Hemolysis also can manifest as jaundice, cholelithiasis, or isolated reticulocytosis. Pathophysiology There are two mechanisms of hemolysis.[aafp.org] […] corpuscular hemoglobin concentration frequently is elevated. 2 , 21 Splenectomy effectively arrests the extravascular hemolysis and prevents its long-term complications, such as cholelithiasis[aafp.org] […] corpuscular hemoglobin concentration frequently is elevated. 2, 21 Splenectomy effectively arrests the extravascular hemolysis and prevents its long-term complications, such as cholelithiasis[aafp.org]

  • Glycogen Storage Disease Type 1

    Hyperlipidemia may cause xanthomas, pancreatitis, and cholelithiasis[ 17 ]. With ageing the prevalence of renal involvement increases[ 25 ].[wjgnet.com] […] levels remain above 10.0 mmol/L despite optimizing dietary treatment, triglyceride-lowering drugs (nicotinic acid, fibrates) should be recommended to reduce the risk of cholelithiasis[wjgnet.com]

  • Hereditary Elliptocytosis

    Cholelithiasis (pigment stones) is common and may be the presenting symptom.[msdmanuals.com] , as in patients with congenital nonspherocytic hemolytic anemia due to glucose-6-phosphate dehydrogenase or pyruvate kinase deficiency.[mayomedicallaboratories.com] Complications such as splenomegaly and cholelithiasis, resulting from increased red cell trapping in the spleen and elevated bilirubin levels, respectively, may occur.[bredagenetics.com]

  • Waters-West Syndrome

    Patients often present with ANEMIA; JAUNDICE and SPLENOMEGALY, resulting in complications that may include CHOLELITHIASIS; HEMOLYSIS, and aplastic crises.[ncbi.nlm.nih.gov] MalaCards based summary : Hemolytic Anemia, Lethal Congenital Nonspherocytic, with Genital and Other Abnormalities, is also known as hemolytic anemia lethal congenital nonspherocytic[malacards.org] Back in the 1950’s and 1960’s we called it Familial Congenital Nonspherocytic Hemolytic Anemia Glucose 6 Phosphate Dehydrogenase Deficiency.[g6pddeficiency.org]

  • Hemolytic Anemia due to a Disorder of Glycolytic Enzymes

    Cholelithiasis sometimes requires surgery. Most of the symptoms are limited to early life and at times of physiologic stress or infection.[wohproject.org] Summary Epidemiology PK deficiency is the most frequent cause of congenital nonspherocytic hemolytic anemia with a prevalence estimated at 1/20,000 in the general white population[orpha.net] anemia and congenital hemolytic anemia.[malacards.org]

  • Acquired Hemolytic Anemia

    , splenomegaly, periodic episodes of hemolysis with jaundice, increased pigmented gallstones Complications of hereditary spherocytosis aplastic crisis, hemolytic crisis, cholelithiasis[memorize.com] Congenital Nonspherocytic Hemolytic Anemia includes any of a group of inherited anemias characterized by shortened red cell survival, lack of spherocytosis, and normal osmotic[diagnose-me.com] Hemolysis also can manifest as jaundice, cholelithiasis, or isolated reticulocytosis. Pathophysiology There are two mechanisms of hemolysis.[aafp.org]

  • Hexokinase Deficiency

    Hexokinase Deficiency Synonyms - Classification genetic, haematological Phenotypes Abnormality of metabolism/homeostasis ; Autosomal recessive inheritance ; Cholecystitis ; Cholelithiasis[mousephenotype.org] The findings were entirely different from those of subsequently reported cases with congenital, nonspherocytic hemolytic anemia associated only with a specific deficiency[jamanetwork.com] […] mainly characterized by severe, chronic hemolysis , beginning in infancy. 0001939 Autosomal recessive inheritance 0000007 Cholecystitis Gallbladder inflammation 0001082 Cholelithiasis[rarediseases.info.nih.gov]

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