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22 Possible Causes for Cholelithiasis, Dark Urine, Physiological Neonatal Jaundice

  • Extrahepatic Cholestasis

    Instead, the increased surface density of the mitochondrial cristae, which has also been previously reported in patients with uncomplicated cholelithiasis, appears as an early[ncbi.nlm.nih.gov] Whereas physiologic jaundice constitutes a common finding in neonates, a few cases present with cholestatic jaundice owing to various pathologic conditions, including extrahepatic[ncbi.nlm.nih.gov] The biochemical derangement is reinforced by clinical symptoms and signs: pale stool - no bilirubin reaching gastrointestinal tract for conversion to stercobilin dark orange[gpnotebook.co.uk]

  • Jaundice

    This is called “physiologic” or normal neonatal jaundice. Most infants have this pattern so no testing is needed.[patients.gi.org] You may also have dark urine and pale stools.[healthline.com] Clonorchis sinensis, the pathogen, is the major parasitic trigger contributing to cholangitis, cholelithiasis, and even cholangiocarcinoma.[ncbi.nlm.nih.gov]

  • Hereditary Spherocytosis

    This is a report of an 11 years old male diagnosed case of hereditary spherocytosis who presented with jaundice, splenomegaly and cholelithiasis.[ncbi.nlm.nih.gov] Applicable To Neonatal physiological jaundice (intense)(prolonged) NOS spherocytosis D58.0 (congenital) Spherocytosis (congenital) (familial) (hereditary) D58.0 hemoglobin[icd10data.com] Hemolytic crisis results from rapid red cell destruction leading to jaundice, passage of dark urine and anemia. Blood transfusion is the immediate remedial measure.[symptoma.com]

  • Liver Cirrhosis

    […] history of alcohol excess, neonatal jaundice, hypertension, or hypercholesterolemia.[atsjournals.org] If you notice symptoms of liver damage (such as jaundice, dark urine, or pain in your abdomen) speak to your doctor and let her know about any drugs you may be taking.[health.com] Hepatitis B Electron micrograph of hepatitis B virus Specialty Infectious disease, gastroenterology Symptoms None, yellowish skin, tiredness, dark urine, abdominal pain Classification[en.wikipedia.org]

  • Neonatal Hepatitis

    Extrahepatic etiologies are extrahepatic biliary atresia choledochal cyst, bile duct stenosis, spontaneous perforation of the bile duct cholelithiasis, inspissated bile/mucus[youtube.com] Infants with this condition are usually jaundiced. Jaundice that is caused by neonatal hepatitis is not the same as physiologic neonatal jaundice.[en.wikipedia.org] EXTRAHEPATIC ETIOLOGIESEXTRAHEPATIC ETIOLOGIES Extrahepatic biliary atresia Choledochal cyst Bile duct stenosis Spontaneous perforation of the bile duct Cholelithiasis Inspissated[slideshare.net]

  • Cardiac Cirrhosis

    Postcholecystectomy syndrome Bile duct / other biliary tree Cholangitis ( PSC, Ascending ) · Cholestasis / Mirizzi's syndrome · Biliary fistula · Haemobilia · Gallstones / Cholelithiasis[wikidoc.org] Physiological neonatal jaundice (we will see this in another chapter). Enzyme deficiencies. E.g. Glucose 6 phosphate dehydrogenase deficiency. Impaired liver function.[mediktor.com] It manifests with a yellow tint, itching and dark stools/urine, associated with increased bilirubin and the symptoms from the triggering disease.[mediktor.com]

  • Biliary Atresia

    Differential diagnosis Other causes of obstructive jaundice - choledochal cyst, cholelithiasis and spontaneous perforation of the bile duct can all occur in the neonatal period[patient.info] Issues that should raise your concern: Prolonged neonatal jaundice Physiologic jaundice in healthy, full-term newborns typically resolves by the 5th or 6th day.[pedemmorsels.com] Other symptoms may include: Dark urine Enlarged spleen Floating stools Foul-smelling stools Pale or clay-colored stools Slow growth Slow or no weight gain The health care[nlm.nih.gov]

  • Gilbert Syndrome

    […] for gallstone formation, there are reasons for postulating that the association of this common inherited disorder of hepatic bilirubin metabolism with HS could increase cholelithiasis[ncbi.nlm.nih.gov] jaundice, unspecified 2016 2017 2018 2019 Billable/Specific Code Code on Newborn Record Applicable To Neonatal physiological jaundice (intense)(prolonged) NOS due to or associated[icd10data.com] A person with Gilbert’s syndrome has normal (straw-coloured) urine. A person with hepatitis will usually have dark urine and may also have a fever.[betterhealth.vic.gov.au]

  • Indian Childhood Cirrhosis

    […] vascular occlusion resulting in tissue ischemia and acute and chronic organ dysfunction; complications include anemia, jaundice, predisposition to aplastic crisis, sepsis, cholelithiasis[animals-partner.blogspot.com] It typically presents with transient neonatal jaundice, in a child who is otherwise healthy, and progresses to biliary cirrhosis and portal hypertension.[ncbi.nlm.nih.gov] The same bile pigment, bilirubin, which is responsible for the yellow skin tones of jaundice can turn urine dark.[chp.edu]

  • Crigler-Najjar Syndrome Type 1

    A Greek study of 198 adult patients with cholelithiasis, along with 152 controls, also found evidence of an association between Gilbert syndrome and the development of cholelithiasis[emedicine.com] Physiological neonatal jaundice may peak at 85–170 µmol/l and decline to normal adult concentrations within two weeks. Prematurity results in higher levels.[en.wikipedia.org] This occurs in some infants with cholestatic jaundice and is manifested by a dark, grayish brown discoloration of the skin, serum, and urine.[emedicine.medscape.com]

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