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16 Possible Causes for Cholelithiasis, Direct Bilirubin Increased, Physiological Neonatal Jaundice

  • Extrahepatic Cholestasis

    Instead, the increased surface density of the mitochondrial cristae, which has also been previously reported in patients with uncomplicated cholelithiasis, appears as an early[ncbi.nlm.nih.gov] Whereas physiologic jaundice constitutes a common finding in neonates, a few cases present with cholestatic jaundice owing to various pathologic conditions, including extrahepatic[ncbi.nlm.nih.gov] An increase in urinary bilirubin is nearly always indicative of a corresponding increase in the serum direct fraction attributable to intrahepatic or extrahepatic cholestasis[medical-dictionary.thefreedictionary.com]

  • Neonatal Hepatitis

    Extrahepatic etiologies are extrahepatic biliary atresia choledochal cyst, bile duct stenosis, spontaneous perforation of the bile duct cholelithiasis, inspissated bile/mucus[youtube.com] Infants with this condition are usually jaundiced. Jaundice that is caused by neonatal hepatitis is not the same as physiologic neonatal jaundice.[en.wikipedia.org] However, bilirubin again increased to 13.2 mg/dl at 5 months of age in spite of HSV IgG.[mjdrdypu.org]

  • Hereditary Spherocytosis

    This is a report of an 11 years old male diagnosed case of hereditary spherocytosis who presented with jaundice, splenomegaly and cholelithiasis.[ncbi.nlm.nih.gov] Applicable To Neonatal physiological jaundice (intense)(prolonged) NOS spherocytosis D58.0 (congenital) Spherocytosis (congenital) (familial) (hereditary) D58.0 hemoglobin[icd10data.com] Assessment of total, direct, and indirect serum bilirubin, erythrocyte morphology and red cell characteristics (particularly mean corpuscular volume and mean sphered corpuscular[ncbi.nlm.nih.gov]

  • Rotor Syndrome

    […] hemolytic jaundice, prehepatic jaundice, hepatic jaundice, posthepatic jaundice, obstructive jaundice, wilson's disease, hepatitis virus B, hepatitis virus C, HBV, HCV, Cholelithiasis[slideshare.net] Neonatal jaundice and Breast-milk jaundice Conjugated hyperbilirubinaemia Hepatocellular – Diminished hepatocyte function.[lifeinthefastlane.com] This is similar to Dubin-Johnson syndrome and both leads to increase conjugated (direct) bilirubin.[labpedia.net]

  • Liver Cirrhosis

    […] history of alcohol excess, neonatal jaundice, hypertension, or hypercholesterolemia.[atsjournals.org] – measures all of the bilirubin in the blood; levels are increased with many liver diseases Direct bilirubin – measures a form of bilirubin that is conjugated (combined with[labtestsonline.org] There was no correlation between the presence of severe fibrosis or cirrhosis and other physiologic parameters of pulmonary function, age, family history of liver disease,[atsjournals.org]

  • Cardiac Cirrhosis

    Postcholecystectomy syndrome Bile duct / other biliary tree Cholangitis ( PSC, Ascending ) · Cholestasis / Mirizzi's syndrome · Biliary fistula · Haemobilia · Gallstones / Cholelithiasis[wikidoc.org] Physiological neonatal jaundice (we will see this in another chapter). Enzyme deficiencies. E.g. Glucose 6 phosphate dehydrogenase deficiency. Impaired liver function.[mediktor.com] ., generating indirect or direct hyperbilirubinaemia. Causes Causes of increased indirect/unconjugated bilirubin: Haemolysis.[mediktor.com]

  • Biliary Atresia

    Differential diagnosis Other causes of obstructive jaundice - choledochal cyst, cholelithiasis and spontaneous perforation of the bile duct can all occur in the neonatal period[patient.info] Issues that should raise your concern: Prolonged neonatal jaundice Physiologic jaundice in healthy, full-term newborns typically resolves by the 5th or 6th day.[pedemmorsels.com] We evaluated the clinical impact and cost of reflex testing in infants with increased direct bilirubin ( 1.5 mg/dL; 25 μmol/L).[ncbi.nlm.nih.gov]

  • Crigler-Najjar Syndrome Type 1

    A Greek study of 198 adult patients with cholelithiasis, along with 152 controls, also found evidence of an association between Gilbert syndrome and the development of cholelithiasis[emedicine.com] Physiological neonatal jaundice may peak at 85–170 µmol/l and decline to normal adult concentrations within two weeks. Prematurity results in higher levels.[en.wikipedia.org] The jaundice worsened following appendectomy, and the direct-reacting bilirubin increased, probably due to the ceftizoxime administered postoperatively.[ncbi.nlm.nih.gov]

  • Gilbert Syndrome

    […] for gallstone formation, there are reasons for postulating that the association of this common inherited disorder of hepatic bilirubin metabolism with HS could increase cholelithiasis[ncbi.nlm.nih.gov] jaundice, unspecified 2016 2017 2018 2019 Billable/Specific Code Code on Newborn Record Applicable To Neonatal physiological jaundice (intense)(prolonged) NOS due to or associated[icd10data.com] GS patients have a ratio of unconjugated/conjugated (indirect/direct) bilirubin commensurately higher than those without GS.[en.wikipedia.org]

  • Transient Familial Neonatal Hyperbilirubinemia

    A Greek study of 198 adult patients with cholelithiasis, along with 152 controls, also found evidence of an association between Gilbert syndrome and the development of cholelithiasis[emedicine.medscape.com] Preferred Name Fetal and neonatal jaundice, NOS Synonyms Physiologic jaundice in newborn, NOS ID altLabel Physiologic jaundice in newborn, NOS Neonatal jaundice, NOS Foetal[purl.bioontology.org] It is reported to have a 0.09 unit increase on Bilirubin levels (Direct bilirubin). No specific risk allele was identified in the study.[selfdecode.com]

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