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21 Possible Causes for Cholelithiasis, Kernicterus, Physiological Neonatal Jaundice

  • Hereditary Spherocytosis

    This is a report of an 11 years old male diagnosed case of hereditary spherocytosis who presented with jaundice, splenomegaly and cholelithiasis.[ncbi.nlm.nih.gov] Applicable To Neonatal physiological jaundice (intense)(prolonged) NOS spherocytosis D58.0 (congenital) Spherocytosis (congenital) (familial) (hereditary) D58.0 hemoglobin[icd10data.com] Among neonates listed in the USA Kernicterus Registry, HS was the third most common underlying hemolytic condition after glucose-6-phosphate dehydrogenase deficiency and ABO[ncbi.nlm.nih.gov]

  • Crigler-Najjar Syndrome Type 1

    A Greek study of 198 adult patients with cholelithiasis, along with 152 controls, also found evidence of an association between Gilbert syndrome and the development of cholelithiasis[emedicine.com] Physiological neonatal jaundice may peak at 85–170 µmol/l and decline to normal adult concentrations within two weeks. Prematurity results in higher levels.[en.wikipedia.org] This case report describes a young adult with Crigler-Najjar syndrome type II in whom kernicterus developed after a laparoscopic cholecystectomy.[ncbi.nlm.nih.gov]

  • Transient Familial Neonatal Hyperbilirubinemia

    A Greek study of 198 adult patients with cholelithiasis, along with 152 controls, also found evidence of an association between Gilbert syndrome and the development of cholelithiasis[emedicine.medscape.com] Preferred Name Fetal and neonatal jaundice, NOS Synonyms Physiologic jaundice in newborn, NOS ID altLabel Physiologic jaundice in newborn, NOS Neonatal jaundice, NOS Foetal[purl.bioontology.org] […] encephalopathy, jaundice; kernicterus, kernicterus; jaundice, kernicterus; newborn, Kernicterus of newborn, NOS, Kernicterus of newborn NOS Dutch bilirubine encefalopatie,[fpnotebook.com]

  • Jaundice

    This is called “physiologic” or normal neonatal jaundice. Most infants have this pattern so no testing is needed.[patients.gi.org] Early detection and management of jaundice can prevent kernicterus.[web.archive.org] Clonorchis sinensis, the pathogen, is the major parasitic trigger contributing to cholangitis, cholelithiasis, and even cholangiocarcinoma.[ncbi.nlm.nih.gov]

  • Neonatal Hepatitis

    Extrahepatic etiologies are extrahepatic biliary atresia choledochal cyst, bile duct stenosis, spontaneous perforation of the bile duct cholelithiasis, inspissated bile/mucus[youtube.com] Infants with this condition are usually jaundiced. Jaundice that is caused by neonatal hepatitis is not the same as physiologic neonatal jaundice.[en.wikipedia.org] This is known as kernicterus Sepsis (blood infection) Skin gets affected such that bruising might occur easily. There could also be a bleeding tendency.[dovemed.com]

  • Liver Cirrhosis

    […] history of alcohol excess, neonatal jaundice, hypertension, or hypercholesterolemia.[atsjournals.org] Severe defects in bilirubin transport and conjugation can lead to markedly elevated unconjugated bilirubin levels, which can cause serious neurologic damage (kernicterus)[aafp.org] There was no correlation between the presence of severe fibrosis or cirrhosis and other physiologic parameters of pulmonary function, age, family history of liver disease,[atsjournals.org]

  • Rotor Syndrome

    […] hemolytic jaundice, prehepatic jaundice, hepatic jaundice, posthepatic jaundice, obstructive jaundice, wilson's disease, hepatitis virus B, hepatitis virus C, HBV, HCV, Cholelithiasis[slideshare.net] Neonatal jaundice and Breast-milk jaundice Conjugated hyperbilirubinaemia Hepatocellular – Diminished hepatocyte function.[lifeinthefastlane.com] However, individual differences in bilirubin sensitivity can result in kernicterus at lower bilirubin levels.[themedicalbiochemistrypage.org]

  • Gilbert Syndrome

    […] for gallstone formation, there are reasons for postulating that the association of this common inherited disorder of hepatic bilirubin metabolism with HS could increase cholelithiasis[ncbi.nlm.nih.gov] jaundice, unspecified 2016 2017 2018 2019 Billable/Specific Code Code on Newborn Record Applicable To Neonatal physiological jaundice (intense)(prolonged) NOS due to or associated[icd10data.com] This situation can be especially dangerous if not quickly treated, as the high bilirubin causes irreversible neurological disability in the form of kernicterus.[en.wikipedia.org]

  • Crigler-Najjar Syndrome Type 2

    A Greek study of 198 adult patients with cholelithiasis, along with 152 controls, also found evidence of an association between Gilbert syndrome and the development of cholelithiasis[emedicine.medscape.com] Physiological neonatal jaundice may peak at 85–170 µmol/l and decline to normal adult concentrations within two weeks. Prematurity results in higher levels.[en.wikipedia.org] At very high concentrations, it can pass through the blood-brain barrier and cause kernicterus, a severe, often fatal neurological disease.[symptoma.com]

  • Breast Milk Jaundice

    The following conditions can also cause jaundice in older children: gallstones (cholelithiasis), crystals that build up in the gallbladder and obstruct the biliary duct infection[childrenshospital.org] neonatal jaundice is a diagnosis of exclusion![amboss.com] It does not generally cause kernicterus.[wikem.org]

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