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31 Possible Causes for Chronic Active Hepatitis, Hepatomegaly, Virus Associated Hemophagocytic Syndrome

  • Infectious Mononucleosis

    The patient showed severe hepatomegaly incidentally, and dual positivity of Immunoglobulin (Ig) M to Epstein-Barr virus (EBV) viral capsid antigen (VCA) and cytomegalovirus[ncbi.nlm.nih.gov] Treatment of patients with infectious mononucleosis need not include prolonged bed rest and restriction of activity in an effort to avoid the development of chronic liver[link.springer.com] Severe chronic active Epstein-Barr virus infection accompanied by virus-associated hemophagocytic syndrome, cerebellar ataxia and encephalitis.[emedicine.medscape.com]

  • Chronic Active Hepatitis B

    Clinical signs include liver tenderness, hepatomegaly, and splenomegaly. Acute HBV infection typically lasts two to four months.[aafp.org] Abstract Reports on the histologic findings of chronic active hepatitis C (CAH-C) have been rare, and the characteristic histologic findings of CAH-C have been not yet determined[ncbi.nlm.nih.gov] Bone marrow biopsy showed hypocellularity, histiocytic hyperplasia, and hemophagocytosis consistent with a virus-associated hemophagocytic syndrome (VAHS).[ncbi.nlm.nih.gov]

  • Autoimmune Hepatitis

    CT Nonspecific, ranging from normal to hepatomegaly and cirrhosis.[radiopaedia.org] […] the liver cells Autoimmune Hepatitis Autoimmune chronic active hepatitis Autoimmune hepatitis (disorder) autoimmune hepatitis with centrilobular necrosis AIH Chronic autoimmune[wikidata.org] Virus-, drug- and lymphoma-associated hemophagocytic syndrome (HPS) was ruled out. Therefore, the patient was diagnosed with autoimmune-associated HPS (AAHS).[ncbi.nlm.nih.gov]

  • Hepatosplenomegaly

    Hepatomegaly in the absence of signs of CLD is unlikely to be due to cirrhosis. Consider a malignancy instead.[quizlet.com] […] anaemia sickle cell anaemia thalassaemia chronic liver disease and portal hypertension: chronic active hepatitis amyloidosis acromegaly systemic lupus erythematosus Links:[gpnotebook.co.uk] T-cell lymphoma and the virus-associated hemophagocytic syndrome. Am J Clin Pathol. 1991; 97 :189–194. [ PubMed ] 16.[ncbi.nlm.nih.gov]

  • Familial Hemophagocytic Lymphohistiocytosis

    Diagnosis is challenging because it mimics severe sepsis by demonstrating hepatomegaly, splenomegaly, persistent fever, central nervous system involvement, and cytopenias.[ncbi.nlm.nih.gov] Fatal virus-associated hemophagocytic syndrome associated with coexistent chronic active hepatitis B and acute hepatitis C virus infection.[dovepress.com] It is concluded that a viral infection cannot serve as the sole criterion for distinguishing a virus-associated hemophagocytic syndrome as an entity separate from familial[ncbi.nlm.nih.gov]

  • Chronic Active Hepatitis

    […] to symptomatic decompensated cirrhosis Many patients are asymptomatic or have mild nonspecific complaints such as fatigue Physical findings are typically few; may include hepatomegaly[pathologyoutlines.com] Chronic active hepatitis should be included in the differential diagnosis of abdominal lymphadenopathy.[ncbi.nlm.nih.gov] Bone marrow biopsy showed hypocellularity, histiocytic hyperplasia, and hemophagocytosis consistent with a virus-associated hemophagocytic syndrome (VAHS).[ncbi.nlm.nih.gov]

  • Hepatosplenic Lymphoma

    It occurs mainly in young adults presenting with splenomegaly and most often with hepatomegaly but without lymphadenopathy.[bloodjournal.org] Primary hepatic malignant lymphoma:its occurrence in a patient with chronic active hepatitis, cirrhosis, and hepatocellular carcinoma associated with hepatitis B viral infection[tropicalgastro.com] In 1 patient, a low level of fibrinogen associated with increased triglyceridemia and ferritinemia suggested hemophagocytic syndrome, which was confirmed by bone marrow examination[bloodjournal.org]

  • Lymphoma

    Hepatomegaly. Intermediate- and high-grade lymphomas: Most patients present with rapidly growing and bulky lymphadenopathy.[patient.info] Known hepatitis C virus (HCV) positive with chronic HCV or active viral infection with HCV hepatitis requiring anti-viral medication (at time of randomization).[clinicaltrials.gov] Hodgkin lymphoma-associated hemophagocytic syndrome: a disorder strongly correlated with Epstein-Barr virus. Clin Infect Dis. 2008 Aug 15. 47(4):531-4. [Medline].[emedicine.medscape.com]

  • Hodgkin Lymphoma

    The presenting feature common in all cases was superficial lymphadenopathy followed by hepatomegaly in 17 (20%) cases and splenomegaly in 16 (19%).[ncbi.nlm.nih.gov] EBV-associated diseases [ edit ] Chronic active EBV infection Hodgkin's disease Acute renal failure [10] Alice in Wonderland syndrome Common variable immunodeficiency (CVID[en.wikipedia.org] Hodgkin lymphoma-associated hemophagocytic syndrome: a disorder strongly correlated with Epstein-Barr virus. Clin Infect Dis. 2008 Aug 15. 47(4):531-4. [Medline].[emedicine.medscape.com]

  • Hyperammonemia Type 3

    A congenital form occurs in two types: Type 1, due to deficiency of the enzyme ornithine carbamoyltransferase, is marked by vomiting, lethargy, coma, and hepatomegaly; symptoms[medical-dictionary.thefreedictionary.com] syndrome, Epstein-Barr immunodeficiency syndrome, Epstein-Barr virus-associated hemophagocytic syndrome, Erysichthon syndrome, ETF syndrome, Euthyroid syndrome, Excision[acronymattic.com] The impairment can be secondary to generalized hepatic dysfunction from acute or chronic liver disease or from deficient enzyme activity of one of several enzymes responsible[clinicaladvisor.com]

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