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30 Possible Causes for Chronic Active Hepatitis, Splenomegaly, Virus Associated Hemophagocytic Syndrome

  • Infectious Mononucleosis

    Clinical estimates of splenomegaly are fallible.[ncbi.nlm.nih.gov] Treatment of patients with infectious mononucleosis need not include prolonged bed rest and restriction of activity in an effort to avoid the development of chronic liver[link.springer.com] Severe chronic active Epstein-Barr virus infection accompanied by virus-associated hemophagocytic syndrome, cerebellar ataxia and encephalitis.[emedicine.medscape.com]

  • Autoimmune Hepatitis

    Physical exam was remarkable for digital clubbing, splenomegaly and orthodeoxia.[ncbi.nlm.nih.gov] […] the liver cells Autoimmune Hepatitis Autoimmune chronic active hepatitis Autoimmune hepatitis (disorder) autoimmune hepatitis with centrilobular necrosis AIH Chronic autoimmune[wikidata.org] Virus-, drug- and lymphoma-associated hemophagocytic syndrome (HPS) was ruled out. Therefore, the patient was diagnosed with autoimmune-associated HPS (AAHS).[ncbi.nlm.nih.gov]

  • Hepatosplenomegaly

    Splenomegaly associated with portal hypertension results in platelet sequestration and thrombocytopenia. 2.[quizlet.com] […] anaemia sickle cell anaemia thalassaemia chronic liver disease and portal hypertension: chronic active hepatitis amyloidosis acromegaly systemic lupus erythematosus Links:[gpnotebook.co.uk] T-cell lymphoma and the virus-associated hemophagocytic syndrome. Am J Clin Pathol. 1991; 97 :189–194. [ PubMed ] 16.[ncbi.nlm.nih.gov]

  • Chronic Active Hepatitis B

    Clinical signs include liver tenderness, hepatomegaly, and splenomegaly. Acute HBV infection typically lasts two to four months.[aafp.org] Abstract Reports on the histologic findings of chronic active hepatitis C (CAH-C) have been rare, and the characteristic histologic findings of CAH-C have been not yet determined[ncbi.nlm.nih.gov] Bone marrow biopsy showed hypocellularity, histiocytic hyperplasia, and hemophagocytosis consistent with a virus-associated hemophagocytic syndrome (VAHS).[ncbi.nlm.nih.gov]

  • Familial Hemophagocytic Lymphohistiocytosis

    Familial hemophagocytic lymphohistiocytosis (FHLH) is an autosomal recessively inherited multisystem disease characterized by fever, rash, splenomegaly, cytopenias, and variable[ncbi.nlm.nih.gov] Fatal virus-associated hemophagocytic syndrome associated with coexistent chronic active hepatitis B and acute hepatitis C virus infection.[dovepress.com] It is concluded that a viral infection cannot serve as the sole criterion for distinguishing a virus-associated hemophagocytic syndrome as an entity separate from familial[ncbi.nlm.nih.gov]

  • Chronic Active Hepatitis

    Signs of chronic liver disease usually develop and include the following: (a) Splenomegaly (spleen enlargement).[armymedical.tpub.com] Chronic active hepatitis should be included in the differential diagnosis of abdominal lymphadenopathy.[ncbi.nlm.nih.gov] Bone marrow biopsy showed hypocellularity, histiocytic hyperplasia, and hemophagocytosis consistent with a virus-associated hemophagocytic syndrome (VAHS).[ncbi.nlm.nih.gov]

  • Hepatosplenic Lymphoma

    Splenectomy was performed due to progressive splenomegaly.[adc.bmj.com] Primary hepatic malignant lymphoma:its occurrence in a patient with chronic active hepatitis, cirrhosis, and hepatocellular carcinoma associated with hepatitis B viral infection[tropicalgastro.com] In 1 patient, a low level of fibrinogen associated with increased triglyceridemia and ferritinemia suggested hemophagocytic syndrome, which was confirmed by bone marrow examination[bloodjournal.org]

  • Lymphoma

    At diagnosis, patients usually present with adenopathy and, in 50% of cases, splenomegaly.[orpha.net] Known hepatitis C virus (HCV) positive with chronic HCV or active viral infection with HCV hepatitis requiring anti-viral medication (at time of randomization).[clinicaltrials.gov] Hodgkin lymphoma-associated hemophagocytic syndrome: a disorder strongly correlated with Epstein-Barr virus. Clin Infect Dis. 2008 Aug 15. 47(4):531-4. [Medline].[emedicine.medscape.com]

  • Hodgkin Lymphoma

    The presenting feature common in all cases was superficial lymphadenopathy followed by hepatomegaly in 17 (20%) cases and splenomegaly in 16 (19%).[ncbi.nlm.nih.gov] EBV-associated diseases [ edit ] Chronic active EBV infection Hodgkin's disease Acute renal failure [10] Alice in Wonderland syndrome Common variable immunodeficiency (CVID[en.wikipedia.org] Hodgkin lymphoma-associated hemophagocytic syndrome: a disorder strongly correlated with Epstein-Barr virus. Clin Infect Dis. 2008 Aug 15. 47(4):531-4. [Medline].[emedicine.medscape.com]

  • Hypersplenism

    RESULTS: While 38 patients displayed splenomegaly, 121 showed normal spleen volumes at 6 months after LDLT (LDLT).[ncbi.nlm.nih.gov] Four patients had portal vein obstruction and three had hepatic cirrosis, two patients had chronic active hepatitis with hypersplenism.[ijri.org] Case Report. ( 27227931 ) Lu X.X....Zheng S. 2016 21 Severe hypersplenism associated to hemophagocytic and lymphoproliferative syndrome secondary to Epstein-Barr virus infection[malacards.org]

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