Chronic Progressive External Ophthalmoplegia: Causes & Reasons

Possible Causes for Chronic Progressive External Ophthalmoplegia

These findings are typical of an infranuclear gaze palsy, in this case chronic, progressive external ophthalmoplegia (CPEO). [neurocular.com]

Chronic Progressive External/complications* Ophthalmoplegia, Chronic Progressive External/physiopathology Otoacoustic Emissions, Spontaneous/physiology Prevalence Substance [ncbi.nlm.nih.gov]

Discussion Chronic Progressive External Ophthalmoplegia (CPEO) - Kearns Sayre Syndrome Dr. [webeye.ophth.uiowa.edu]

MERRF Syndrome

Disorders evaluated in Mayo's Mitochondrial Disease Clinic include, among others: Alpers progressive sclerosing poliodystrophy (Alpers disease) Barth syndrome Chronic progressive [mayoclinic.org]

progressive external ophthalmoplegia (CPEO) including Kearns-Sayre syndrome1–5. [typeset.io]

"Chronic progressive external ophthalmoplegia: a new heteroplasmic tRNA(Leu(CUN)) mutation of mitochondrial DNA". [mitomap.org]

Oculopharyngeal Muscular Dystrophy

Keywords Muscular Dystrophy Myotonic Dystrophy Inclusion Body Myositis Chronic Progressive External Ophthalmoplegia Levator Palpebrae These keywords were added by machine [link.springer.com]

progressive external ophthalmoplegia) Fascioscapulohumeral muscular dystrophy Miller-Fisher syndrome Amyotrophic lateral sclerosis Oculopharyngodistal myopathy Best Tests [visualdx.com]

OPMD falls within the category of non-congenital, myogenic ptosis, which also includes chronic progressive external ophthalmoplegia and myotonic dystrophy ( Wong et al., 2002 [eyerounds.org]

Sensory Ataxic Neuropathy - Dysarthria - Ophthalmoparesis Syndrome

Chronic progressive external ophthalmoplegia with inflammatory myopathy. Int J Clin Exp Pathol. 2014. 7 (12):8887-92. [Medline]. [emedicine.medscape.com]

progressive external ophthalmoplegia. [orpha.net]

MR of extraocular muscles in chronic progressive external ophthalmoplegia. AJNR Am J Neuroradiol. 1998 Jan. 19(1):95-9. [Medline]. [emedicine.medscape.com]

Thymidine Kinase 2 Deficiency

We studied identical twin brothers, one of whom presented with chronic progressive external ophthalmoplegia. [jmg.bmj.com]

chronic progressive external ophthalmoplegia, ptosis, dysphagia, and dysarthria. [ncbi.nlm.nih.gov]

Progressive External Ophthalmoplegia (CPEO) Danish patients between 18-80 years of age with verified single large-scale mtDNA deletions and chronic progressive external ophthalmoplegia [mitoaction.org]

Myasthenia Gravis

progressive external ophthalmoplegia (CPEO), and developmental myopathy of the levator palpebrae superioris muscle. [eyewiki.aao.org]

[…] adenoma, aneurysm, fascicular lesion of CN 3, evolving CN 3 palsy, post-viral neuropathy, thyroid disorders*, migraines, meningitis, Horner's syndrome, levator aponeurosis, chronic [eyewiki.aao.org]

Chronic progressive external ophthalmoplegia (CPEO) may manifest as ptosis and decreased eye movements. [emedicine.com]

Blepharoptosis

Chronic progressive external ophthalmoplegia (CPEO) is a neuromyopathic disorder characterized by progressive weakness of the extraocular and levator muscles, which causes [ncbi.nlm.nih.gov]

The ptosis is caused by a glycogenosis type II (Pompe disease) in the first case and is due to a juvenile, chronic progressive external ophthalmoplegia (Kearns-Sayre syndrome [ncbi.nlm.nih.gov]

Lee AG, Brazis PW (2002) Chronic progressive external ophthalmoplegia. Curr Neurol Neurosci Rep 2(5):413–417 CrossRef PubMed 16. [springermedizin.de]

Prolapse

ECG, EMG, mitochondrial studies and electroretinogram may be needed to exclude chronic progressive external ophthalmoplegia. [patient.info]

These conditions may include chronic progressive external ophthalmoplegia and types of muscular dystrophy. [nyulangone.org]

Differential diagnosis Differential diagnosis of congenital ptosis Chronic progressive external ophthalmoplegia (a disorder characterised by slowly progressive paralysis of [patient.info]

Chronic Progressive External Ophthalmoplegia

CPEO stands for "Chronic Progressive External Ophthalmoplegia" How to abbreviate Chronic Progressive External Ophthalmoplegia? [allacronyms.com]

Home / Principles of Ophthalmology / Molecular Genetics Title: Chronic Progressive External Ophthalmoplegia (CPEO)_Moran_3a-10 Author: Kathleen B. [morancore.utah.edu]

external ophthalmoplegia PEO chronic progressive external ophthalmoplegia [Ambiguous] progressive external ophthalmoplegia (disorder) chronic progressive external ophthalmoplegia [wikidata.org]

Short Chain Acyl CoA Dehydrogenase Deficiency

Short-chain acyl-CoA dehydrogenase (SCAD) deficiency is a condition that prevents the body from converting certain fats into energy, especially during periods without food (fasting). Signs and symptoms of SCAD deficiency may appear during infancy or early childhood and can include vomiting, low blood sugar[…] [ghr.nlm.nih.gov]

Diabetic Ophthalmoplegia

Chronic progressive external ophthalmoplegia with inflammatory myopathy. Int J Clin Exp Pathol. 2014. 7 (12):8887-92. [Medline]. [emedicine.medscape.com]

Pigment changes of the retina in chronic progressive external ophthalmoplegia (CPEO). Acta. Ophthalmol. 56: Suppl. 138: 5–36 (1978). [link.springer.com]

progressive external ophthalmoplegia (CPEO). [emedicine.medscape.com]

Autosomal Dominant Progressive External Ophthalmoplegia Type 6

"Frontalis sling operation using silicone rod for the correction of ptosis in chronic progressive external ophthalmoplegia". [en.wikipedia.org]

Chronic progressive external ophthalmoplegia with inflammatory myopathy. Int J Clin Exp Pathol. 2014. 7 (12):8887-92. [Medline]. [emedicine.medscape.com]

Vocal cord palsy in a case of chronic progressive external ophthalmoplegia. [annalsofian.org]

Lethal Infantile Mitochondrial Myopathy

progressive external ophthalmoplegia (CPEO), mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS), myoclonic epilepsy with ragged-red fibers [ncbi.nlm.nih.gov]

Progressive External Ophthalmoplegia KSS Kearns Sayre Syndrome DM Diabetes Mellitus DMDF Diabetes Mellitus + DeaFness CIPO Chronic Intestinal Pseudoobstruction with myopathy [mitomap.org]

Many individuals with a mutation of mtDNA display a cluster of clinical features that fall into a discrete clinical syndrome, such as the Kearns-Sayre syndrome (KSS), chronic [ncbi.nlm.nih.gov]

Mitochondrial Myopathy

progressive external ophthalmoplegia. [ncbi.nlm.nih.gov]

PURPOSE: To quantify the range of brow excursion in patients with mitochondrial myopathy and chronic progressive external ophthalmoplegia (CPEO). [ncbi.nlm.nih.gov]

ophthalmoplegia Cardiac conduction defects Sensorineural hearing loss Chronic progressive external ophthalmoplegia (CPEO) Progressive ophthalmoparesis Symptomatic overlap [en.wikipedia.org]

Ophthalmoplegia

[…] muscle in chronic progressive external ophthalmoplegia. ( 30962064 ) Schlapakow E...Kunz WS 2019 5 Focal Segmental Glomerulosclerosis Associated with Chronic Progressive [malacards.org]

What is chronic progressive external ophthalmoplegia? [patientslikeme.com]

Chronic progressive external ophthalmoplegia with inflammatory myopathy. Int J Clin Exp Pathol. 2014. 7 (12):8887-92. [Medline]. [emedicine.medscape.com]

Autosomal Recessive Spastic Paraplegia Type 7

Mutations in the SPG7 gene cause chronic progressive external ophthalmoplegia through disordered mitochondrial DNA maintenance. Brain. 2014 Apr 10. [disorders.eyes.arizona.edu]

Mutations in the SPG7 gene cause chronic progressive external ophthalmoplegia through disordered mitochondrial DNA maintenance. [molgen.ua.ac.be]

Mutations in the SPG7 gene cause chronic progressive external ophthalmoplegia through disordered mitochondrial DNA maintenance. Brain 2014; 137:1323-36. 5. [neurologyindia.com]

Horizontal Gaze Palsy with Progressive Scoliosis

Chronic Progressive External/complications* Ophthalmoplegia, Chronic Progressive External/diagnosis Ophthalmoplegia, Chronic Progressive External/genetics Receptors, Immunologic [ncbi.nlm.nih.gov]

Chronic Progressive External/genetics Ophthalmoplegia, Chronic Progressive External/pathology Paresis/etiology* Putaminal Hemorrhage/complications* Pyramidal Tracts/pathology [ncbi.nlm.nih.gov]

These are most commonly myopathic in origin, occurring with mitochondrial disorders (chronic progressive external ophthalmoplegia, Kearns-Sayre syndrome, MELAS), myotonic [medlink.com]

Mitochondrial Disease

Four unrelated patients presented with a severe sensory ataxic neuropathy in association with dysarthria and chronic progressive external ophthalmoplegia. [ncbi.nlm.nih.gov]

external ophthalmoplegia. [ncbi.nlm.nih.gov]

The oculoskeletal symptoms of the present cases resemble those of chronic progressive external ophthalmoplegia, a type of mitochondrial disease. [ncbi.nlm.nih.gov]

MELAS Syndrome

• We describe a 15-year-old boy with full-blown mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes (MELAS) and chronic progressive external ophthalmoplegia [jamanetwork.com]

We describe a 15-year-old boy with full-blown mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) and chronic progressive external ophthalmoplegia [ncbi.nlm.nih.gov]

Therefore, the overlapping syndrome of chronic progressive external ophthalmoplegia in the MELAS syndrome is considered in this case. [ncbi.nlm.nih.gov]

Lethal Ataxia with Deafness and Optic Atrophy

Progressive External Ophthalmoplegia (CPEO), Kearns Sayre Syndrome (KSS), Diabetes Mellitus (DM), Diabetes Mellitus and Deafness (DMDF), Chronic Intestinal Pseudoobstruction [brevets-patents.ic.gc.ca]

Progressive External Ophthalmoplegia Maternal Myopathy and Cardiomyopathy Maternally Inherited Hypertrophic Cardiomyopathy Maternally Inherited Cardiomyopathy Fatal Infantile [meduniwien.ac.at]

progressive external ophthalmoplegia Kearns-Sayre LHON Leigh's MELAS (mitochondrial encephalopathy with lactic acidosis and stroke) MERRF (myoclonic epilepsy with ragged [quizlet.com]

Oculo-Pharyngo-Distal Myopathy

= chronic progressive external ophthalmoplegia oc.ph.d. = oculopharyngeal dystrophy Oculopharyngeal dystrophy is a form of chronic progressive external ophthalmoplegia [vdocuments.site]

Abstract Favorites PDF Get Content & Permissions Open Optical coherence tomography findings in chronic progressive external ophthalmoplegia Wu, Yuan; Kang, Lei; Wu, Hai-Long [cmj.org]

OPMD falls within the category of non-congenital, myogenic ptosis, which also includes chronic progressive external ophthalmoplegia and myotonic dystrophy ( Wong et al., 2002 [webeye.ophth.uiowa.edu]

[…] encephalomyopathy/LS/optic atrophy [ 27 ] m.4171C>A MT – ND1 LHON [ 27 ] m.4298G>A MT – TI Chronic progressive external ophthalmoplegia/multiple sclerosis [ 27 ] m.4300A> [basicmedicalkey.com]

Kearns-Sayre Syndrome characterised by chronic progressive external ophthalmoplegia, ptosis, abnormal heart rhythms, diabetes, deafness, pigmented retinopathy and cerebellar [revistanefrologia.com]

Kearns–Sayre syndrome typically includes chronic progressive external ophthalmoplegia, ptosis, and pigmentary retinopathy in individuals less than 20 years of age. [dovepress.com]

Hereditary Myopathy with Lactic Acidosis due to ISCU Deficiency

Progressive External Ophthalmoplegia (CPEO) Multi Gene Panel (9 Genes) Targeted genes: C10orf2 MGME1 POLG POLG2 RRM2B SLC25A4 SPG7 TK2 TYMP Source: Medical Genetisc Center [nextgenerationsequencing.info]

G MT – TI m.4308G>A MT – TI Chronic progressive external ophthalmoplegia [ 27 ] m.4332G>A MT – TQ Encephalopathy/MELAS [ 27 ] m.5537AinsT MT – TW m.5650G>A MT – TA Myopathy [basicmedicalkey.com]

Mitochondrial Neurogastrointestinal Encephalomyopathy

Johnson MA, Turnbull DM, Dick DJ, Sherratt HSA (1983) A partial deficiency of cytochrome c oxidase in chronic progressive external ophthalmoplegia. [doi.org]

Autosomal Recessive Spastic Paraplegia Type 61

Mutations in the SPG7 gene cause chronic progressive external ophthalmoplegia through disordered mitochondrial DNA maintenance. Brain 2014; 137:1323-36. 5. [neurologyindia.com]

Abstract Favorites PDF Get Content & Permissions Open Optical coherence tomography findings in chronic progressive external ophthalmoplegia Wu, Yuan; Kang, Lei; Wu, Hai-Long [cmj.org]

Proximal Myopathy with Extrapyramidal Signs

CATALANO, ROBERT LOVELACE First published August 1, 1974, DOI: https://doi.org/10.1212/WNL.24.8.755 Abstract A boy initially thought to have chronic progressive external ophthalmoplegia [neurology.org]

Chronic progressive external ophthalmoplegia is almost invariably associated with a mitochondrial disease. [jnnp.bmj.com]

Chronic progressive external ophthalmoplegia (CPEO): The age of onset is usually during the 2 nd and 3 rd decades of life. [neuroweb.us]

Mitochondrial Complex 3 Deficiency Nuclear Type 1

CO: cytochrome c oxidase (control: 152.1 + 39.7, n = 161, CPEO: chronic progressive external ophthalmoplegia, KSS: Kearns Sayre syndrome. F: female. [docslide.com.br]

progressive external ophthalmoplegia with mitochondrial myopathy Adult-onset dystonia-parkinsonism Alpers-Huttenlocher syndrome Alpha-N-acetylgalactosaminidase deficiency [se-atlas.de]

—Kearns-Sayre syndrome typically consists of the clinical triad of chronic progressive external ophthalmoplegia (including ptosis), retinal pigmentary degeneration, and cardiac [pubs.rsna.org]

Congenital Ptosis

ECG, EMG, mitochondrial studies and electroretinogram may be needed to exclude chronic progressive external ophthalmoplegia. [patient.info]

These conditions may include chronic progressive external ophthalmoplegia and types of muscular dystrophy. [nyulangone.org]

Patients with ptosis and Kearns-Sayre syndrome or chronic progressive external ophthalmoplegia may also have a cardiac conduction disorder. [eyewiki.aao.org]

Mitochondrial Myopathy with Reversible Cytochrome C Oxidase Deficiency

"Chronic progressive external ophthalmoplegia: a new heteroplasmic tRNA(Leu(CUN)) mutation of mitochondrial DNA". [mitomap.org]

Progressive External Ophthalmoplegia (CPEO) AD-CPEO: Sporadic multiple mtDNA deletions: One deletion affects the heavy strand promoter – HSP region Chromosome 3p Clinical [neurodiffdx.com]

Skeletal muscle pathology in chronic progressive external ophthalmoplegia with ragged-red fibers. Acta Neuropathol. 1988, 76, 558–563. [mdpi.com]

Hereditary Proximal Myopathy with Early Respiratory Failure

Pfeffer G, Sirrs S, Wade NK, Mezei MM (2011) Multisystem disorder in late-onset chronic progressive external ophthalmoplegia. [link.springer.com]

progressive external ophthalmoplegia Maternally-inherited CPEO Maternally-inherited diabetes and deafness Maternally-inherited infantile subacute necrotizing encephalopathy [orpha.net]

Smits BW, Heijdra YF, Cuppen FW, van Engelen BG (2011) Nature and frequency of respiratory involvement in chronic progressive external ophthalmoplegia. [link.springer.com]