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21 Possible Causes for Chvostek Sign, Hyperreninemia, Muscle Weakness

  • Bartter's Disease

    Clinical findings Proximal muscle weakness, failure to thrive, short stature, convulsions, tetany, cramps, ileus, gout, mental retardation, enuresis, nocturia, polyuria, salt[] Hypotension – may be symptomatic or asymptomatic based on volume status Tetany – positive Chvostek’s and Trouseau’s signs may be present in the setting of hypomagnesemia and[] In addition, some affected patients may have neuromuscular irritability as manifested by a positive Chvostek /or Trousseau sign or frank tetany due to alkalosis and hypomagnesemia[]

  • Hypokalemia

    Neurological examination showed a lower extremity muscle weakness with three-fifths muscular strength of the quadriceps and tibialis anterior muscle on both sides.[] sign ipsilateral facial muscle contraction caused by tapping the facial nerve Trousseau sign carpopedal spasms by inflating the sphygmomanometer above systolic blood pressure[] Clinical features include transient periods of muscle weakness and tetany, dizziness, abdominal pains and constipation.[]

  • Conn Syndrome

    Low potassium may cause fatigue, muscle cramps, muscle weakness, numbness, or temporary paralysis.[] When renin increases (due to low blood pressure, decreased blood flow to the kidneys or to a sodium deficiency), aldosterone increases; when renin decreases, aldosterone decreases.In[] Condition similar to Conn's syndrome may be caused by kidneys that can produce an excessive amount of renin.[]

  • Gitelman Syndrome

    The clinical spectrum is wide and usually characterized by chronic fatigue, cramps, muscle weakness and paresthesiae.[] Chvostek's and Trousseau's signs were positive. Her clinical and neurological examinations revealed Grade 3 quadriparesis without sensory loss.[] The main features of this syndrome include normal or low blood pressure, hypokalemia, metabolic alkalosis, hypomagnesemia, hypocalciuria, and hyperreninemia.[]

  • Respiratory Alkalosis

    weakness, depressed central respiratory drive, and resultant alveolar hypoventilation.[] Positive Chvostek’s sign Nausea and vomiting Muscle twitching Assessment CIRCULATION May report: History/presence of anemia Palpitations May exhibit: Hypotension Tachycardia[] , Cl- expansion Renal loss of H : edematous states (heart failure, cirrhosis, nephrotic syndrome), hyperaldosteronism, hypercortisolism, excess ACTH, exogenous steroids, hyperreninemia[]

  • Metabolic Alkalosis

    In most patients, the symptom of muscle weakness and polyuria occur early in life, which may be attributed to potassium depletion.[] weakness; myalgia; muscle cramps; tremors in the hands; and twitching muscles.[] […] month-old boy on an oligoantigenic diet because of multiple food intolerances presented with anorexia, failure to gain weight and severe hypochloremic metabolic alkalosis with hyperreninemia[]

  • Antenatal Bartter Syndrome

    Low blood levels of potassium can cause muscle weakness, cramping, and fatigue.[] In Gitelman syndrome it is sometimes possible to elicit a positive Chvostek sign and carpopedal spasms by inflating a blood pressure cuff.[] Rofecoxib suppressed hyperreninemia to a similar extent as indomethacin.[]

  • Autosomal Dominant Hypocalcemia Type 1

    She also complained of intermittent paresthesias in her hands and feet but denied any muscle weakness or cramps.[] The physical findings which classically demonstrate increased neuromuscular irritability due to hypocalcemia are Trousseau’s sign and Chvostek’s sign.[] Few patients manifest hypocalcemia and features of Bartter syndrome, including hypomagnesemia, hypokalemia, metabolic alkalosis, hyperreninemia, and hyperaldosteronemia.[]

  • Hypocalcemic Vitamin D-Dependent Rickets Type 1B

    In 1961, Prader first described this disorder including severe clinical features of rickets, such as hypophosphatemia, hypocalcemia, muscle weakness and seizure.[] Features of severe hypocalcemia (Chvostek's sign and carpopedal spasms) were positive. Alopecia or features of nutritional deficiency were not observed.[] […] resembling the salt-wasting Bartter syndrome (also referred to as Bartter syndrome subtype V), characterized by hypocalcemia, hypomagnesemia, hypokalemia, metabolic alkalosis, hyperreninemia[]

  • Autosomal Dominant Primary Hypomagnesemia with Hypocalciuria

    Presentation: Hyperventilation, muscle weakness, cardiac arrhythmias (hypokalaemia) and bone pain (due to rickets or osteomalacia).[] Commonly, the physical exam is unremarkable other than that of increased neuromuscular irritability: hyperreflexia, Chvostek sign (twitching of the circumoral muscles when[] These individuals may present with additional symptoms of hypokalemic metabolic alkalosis, hyperreninemia, hyperaldosteronism, and hypomagnesemia, consistent with type V Bartter[]

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