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3,550 Possible Causes for cleavage

  • Influenza

    […] the carbohydrate in the vicinity of the cleavage site.[doi.org] Infectivity of influenza depends on the cleavage of HA by specific host proteases, whereas NA is involved in the release of progeny virions from the cell surface and prevents[ncbi.nlm.nih.gov] The pathogenicity of these strains is related to the presence of a polybasic cleavage sequence in the precursor of the surface glycoprotein haemagglutinin, which makes the[ncbi.nlm.nih.gov]

  • Urinary Tract Infection

    An endopeptidase involved in the cleavage of a variety of substrates, including collagen and extracellular matrix components.[doi.org]

  • Skin Infection

    Staphylococcus scalded skin syndrome, a medical emergency where large sheets of the upper epidermis slough off), large bullae will form as the toxin produces intradermal cleavage[aafp.org]

  • Dementia

    These include inhibitors of beta-secretase (the second endopeptidase involved in Aβ cleavage from its precursor protein), considered by some to be the most promising target[doi.org] […] action of a metalloprotease, which clears it from the plasma; it is thought that the A and B antigens interfere with access to the cleavage site, thereby reducing clearance[ncbi.nlm.nih.gov] Aβ peptide is generated by the sequential cleavage of APP by beta and gamma secretase in the amyloidogenic pathway.[doi.org]

  • Infectious Mononucleosis

    […] of perforin, was added to the cells to block cleavage of perforin.[dx.doi.org] View Article PubMed PubMed Central Google Scholar Kawanishi M, Tada-Oikawa S, Kawanishi S: Epstein-Barr virus BHRF1 functions downstream of Bid cleavage and upstream of mitochondrial[dx.doi.org] The figure includes the cleavage sites for XhoI (X) and the expected fragment sizes after restriction analysis of EBV-wt and ΔBLLF1 genomes.[dx.doi.org]

  • Connective Tissue Disease

    Metabolism Disorders Disease (OMIM Number) Defective Proteins or Enzymes Defective Gene or Genes (Chromosomal Location) Comments Nonketotic hyperglycinemia (605899) Glycine cleavage[merck.com]

  • Malignant Neoplasm

    DNA Methylation Is Induced by I-SceI Cleavage/Recombination Dot plots of GFP expression in clone 3 after I-SceI transfection are presented.[doi.org] Consequently, an extracellular cleavage of proHB-EGF by MMP-7 enhances the availability of soluble HB-EGF (sHB-EGF) which can bind to and interact with the ErbB4 receptor[doi.org] Analysis of Individual DR-GFP Clones The data shown above suggest that recombination products induced by I-SceI cleavage are silenced by methylation.[doi.org]

  • Adrenal Insufficiency

    CONTEXT: Cytochrome P450 side-chain cleavage enzyme (CYP11A1) catalyses the first and rate-limiting step of steroidogenesis, the conversion of cholesterol to pregnenolone.[ncbi.nlm.nih.gov] Abstract We characterized a case of congenital adrenal insufficiency caused by cholesterol side-chain cleavage enzyme (P450scc) deficiency.[ncbi.nlm.nih.gov] BACKGROUND/AIMS: Cholesterol side-chain cleavage enzyme (P450scc) deficiency is a rare genetic disorder causing primary adrenal insufficiency with or without a 46,XY disorder[ncbi.nlm.nih.gov]

  • Tuberculosis

    , 42 ), and thus may inhibit ESAT-6 cleavage to decrease the apparent serum ESAT-6 levels in our assay.[pnas.org] From a biochemical point of view, apoptosis induces a decrease in mitochondrial inner transmembrane potential, activation of selective proteases, cleavage of chromosomal DNA[doi.org] The wide dynamic range of serum protein expression can complicate the cleavage and subsequent detection of low-abundance serum proteins ( 23 ).[pnas.org]

  • Nonketotic Hyperglycinemia

    The diagnosis was confirmed by demonstration of a defect in the activity of the glycine cleavage system in cultured lymphoblasts.[ncbi.nlm.nih.gov] In one patient, the disturbance of the glycine cleavage system was due to absence of activity of the P-protein.[ncbi.nlm.nih.gov] Abstract The activities of then glycine cleavage system in the liver and brain of patient with nonketotic hyperglycinemia was extremely low as compared with those of control[ncbi.nlm.nih.gov]

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