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10 Possible Causes for Cleavage within Basal Keratinocytes

  • Epidermolysis Bullosa Simplex Type Cockayne-Touraine

    within basal keratinocytes.[mendelian.co] Electron microscopy of skin biopsies reveals a plane of cleavage (level of separation) within the bottom layer of the basal keratinocytes, just above the hemidesmosomes.[ncbi.nlm.nih.gov] AUTOSOMAL RECESSIVE 1; EBSB1 Epidermolysis bullosa simplex (EBS) is a clinically and genetically heterogeneous group of disorders characterized by recurrent blistering and cleavage[mendelian.co]

  • Epidermolysis Bullosa Simplex Type Kobner

    within basal keratinocytes; No clumping of keratin filaments in basal epidermal cells; [Nails]; Dystrophic nails (less common) MISCELLANEOUS: Onset at birth or in early infancy[genome.jp] Electron microscopy of skin biopsies reveals a plane of cleavage (level of separation) within the bottom layer of the basal keratinocytes, just above the hemidesmosomes.[ncbi.nlm.nih.gov] Blistering, generalized, recurrent (occurs after mild physical trauma); Hyperkeratosis of the palms and soles; Milia (less common); Lack of scarring; ELECTRON MICROSCOPY:; Cleavage[genome.jp]

  • Autosomal Recessive Epidermolysis Bullosa Simplex

    Format Definition A form of epidermolysis bullosa, a genodermatosis characterized by recurrent blistering and cleavage within basal keratinocytes, fragility of the skin and[uniprot.org] Electron microscopy of skin biopsies reveals a plane of cleavage (level of separation) within the bottom layer of the basal keratinocytes, just above the hemidesmosomes.[ncbi.nlm.nih.gov] Within basal keratinocytes, plectin is localized to the inner plaques of the hemidesmosomes, which are hypoplastic and show poor association with keratin filaments.[ncbi.nlm.nih.gov]

  • Epidermolysis Bullosa Simplex

    Histology, immunofluorescence and electron microscopy of a bullous lesion showed an intraepidermal cleavage and an increased number of melanosomes within basal keratinocytes[karger.com] The diseases are classified according to the level of skin cleavage. In EB simplex (EBS), the cleavage plane is within the basal keratinocytes of the epidermis [ 1 ].[ojrd.biomedcentral.com] Histopathology of the skin showed pronounced acantholysis, and cleavage within the epidermis, with the loss of upper spinous, granular and horny layers.[dx.doi.org]

  • Epidermolysis Bullosa

    Electron microscopy of skin biopsies reveals a plane of cleavage (level of separation) within the bottom layer of the basal keratinocytes, just above the hemidesmosomes.[ncbi.nlm.nih.gov] Within basal keratinocytes, plectin is localized to the inner plaques of the hemidesmosomes, which are hypoplastic and show poor association with keratin filaments.[ncbi.nlm.nih.gov]

  • Junctional Epidermolysis Bullosa

    In epidermolysis bullosa simplex defects in keratin 5 and 14 that make up tonofilaments within the basal keratinocytes cause cell fragility and result in separation from the[jem.rupress.org] In dystrophic forms of EB cleavage occurs just below the basement membrane zone due to defects in anchoring filaments made of collagen VII (( 5 ), ( 6 )).[jem.rupress.org]

  • Ichthyosis-Intellectual Disability-Dwarfism-Renal Impairment Syndrome

    within basal keratinocytes.[mendelian.co] AUTOSOMAL RECESSIVE 1; EBSB1 Epidermolysis bullosa simplex (EBS) is a clinically and genetically heterogeneous group of disorders characterized by recurrent blistering and cleavage[mendelian.co]

  • Anesthetic

    Vacuolization of the basal and suprabasilar layer, pallor and swelling of upper layer epidermal keratinocytes, a pauci-inflammatory cleavage beneath or within the basal layer[ncbi.nlm.nih.gov]

  • Epidermolysis Bullosa-Pyloric Atresia

    Findings on TEM in EB-PA include the following: Cleavage may be within the lamina lucida or just above the hemidesmosomes in the lowest layer of the basal keratinocytes.[ncbi.nlm.nih.gov] […] fibrils; the presence of and morphology of hemidesmosomes, anchoring filaments, and keratin intermediate filaments; and the presence of micro-vesicles showing the tissue cleavage[ncbi.nlm.nih.gov]

  • Adult Junctional Epidermolysis Bullosa

    In epidermolysis bullosa simplex defects in keratin 5 and 14 that make up tonofilaments within the basal keratinocytes cause cell fragility and result in separation from the[jem.rupress.org] In dystrophic forms of EB cleavage occurs just below the basement membrane zone due to defects in anchoring filaments made of collagen VII (( 5 ), ( 6 )).[jem.rupress.org]

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