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213 Possible Causes for Cleft Palate, Clenched Hands, Congenital Heart Disease

  • Patau Syndrome

    Symptoms of the Disease are Extra fingers, decreased muscle tone, clenched hands, small eyes, small head, scalp defects etc.[omicsonline.org] […] lip, and cleft palate.[learningaboutelectronics.com] Most infants with trisomy 13 have congenital heart disease.[nlm.nih.gov]

  • Trisomy 18

    At least 30% of affected fetuses have abnormal extremities (unilateral or bilateral), the most frequent one being clenched hand and radial aplasia.[humpath.com] The oral findings typically observed in these patients are: cleft lip and a high, narrow, and sometimes cleft palate.[ncbi.nlm.nih.gov] A prenatal diagnosis of ductal-dependent, complex congenital heart disease was made in a fetus with trisomy 18.[ncbi.nlm.nih.gov]

  • Partial Trisomy 13 in Patau Syndrome

    hand with finger overlap, rocker bottom feet, micrognathia, low set ears Image depicting classic appearance of clenched hand with overlapping 2nd and 5th fingers in a newborn[pedclerk.bsd.uchicago.edu] Some of the characteristics of Edward syndrome may include: defects of the kidneys, ureters, heart, lungs and diaphragm cleft lip or cleft palate small skull (microcephaly[betterhealth.vic.gov.au] heart disease, blindness, severe mental retardation may complicate survival Please rate topic.[medbullets.com]

  • Pierre Robin Syndrome

    Symptoms include cleft lip or palate, clenched hands (with outer fingers on top of the inner fingers), close-set eyes, decreased muscle tone, extra fingers or toes (polydactyl[doi.org] Skeletal II jaw relation was observed in 32% of the children with isolated cleft palate.[ncbi.nlm.nih.gov] Congenital heart disease occurs in about 20 percent of patients with Pierre Robin syndrome.[ncbi.nlm.nih.gov]

  • Cornelia De Lange Syndrome

    […] contrast, other features characteristic of isochromosome 18p, namely microstomia, prominent upper lip, pinched nose, asymmetric long face, long and narrow fingers/toes, clenched[jmg.bmj.com] When cleft palate alone is associated with a disorder, the underlying pathophysiology for clefting is sometimes secondary due to mechanical blocking of the fusion of the palatal[ncbi.nlm.nih.gov] Congenital heart disease (CHD) is not a major criterion of the disease, but it affects many individuals.[ncbi.nlm.nih.gov]

  • Crouzon Syndrome

    Second-trimester molecular prenatal diagnosis of sporadic Apert syndrome following sonographic findings of mild ventriculomegaly and clenched hands mimicking trisomy 18.[ncbi.nlm.nih.gov] […] a palatal cleft.[doi.org] Child had episodes of cyanosis while crying for which he was evaluated by cardiologist and congenital cyanotic heart diseases were ruled out.[jnaccjournal.org]

  • Apert Syndrome

    Second-trimester molecular prenatal diagnosis of sporadic Apert syndrome following sonographic findings of mild ventriculomegaly and clenched hands mimicking trisomy 18.[eyewiki.aao.org] […] lip parent support group, cleft palate parent support group, cleft, lip, palate, advocate, insurance, birth, defect, cleft lip and palate, cleft lip and cleft palate, cleft[cleftadvocate.org] Other abnormalities includes central nervous system anomalies, congenital heart diseases, cleft palate, and urogenital diseases.[ncbi.nlm.nih.gov]

  • XXXXY Syndrome

    hands.[ncbi.nlm.nih.gov] We have recently seen two patients with the 49,XXXXY syndrome with associated congenital heart disease.[pediatrics.aappublications.org] Cleft palate is rarely seen among these anomalies. A cleft palate deformity can be diagnosed early and easily.[journals.lww.com]

  • Ellis-Van Creveld Syndrome

    Limitation of hand function, such as the inability to form a clenched fist, is frequently observed.[emedicine.com] Often cleft palate and a prenatal dentition can be observed.[neocyst.de] In 1940 Ellis and van Creveld (2) described 2 more patients with similar congenital anomalies who, in addition, had congenital heart disease.[annals.org]

  • Multiple Congenital Anomalies

    hands, rocker-bottom feet, simian crease, distal mottling of the skin, nail hypoplasia, hypoplasia of bones and hydrocephalus.[ncbi.nlm.nih.gov] We report a 20-month-old male from consanguineous parents with multiple congenital anomalies including corpus callosum hypoplasia, facial dysmorphism, cleft palate, pectus[ncbi.nlm.nih.gov] , microphthalmia and cataracts, complex congenital heart disease, rib anomalies, and intestinal malrotation.[ncbi.nlm.nih.gov]

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