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23 Possible Causes for Cleft Vertebrae, Hyperconvex Nails, Widely Spaced Nipples

  • Wolf Hirschhorn Syndrome

    spaced nipples Hypoplasia or duplication of thumbs and great toes Talipes equinovarus Hypoplasia of pubic bones Vertebral and rib anomalies Defective calvaria ossification[emedicine.medscape.com] [ncbi.nlm.nih.gov] Skin Hyperconvex Nails In the hands, notable features include dermal ridges, simian crease in the palms, and hyperconvex nails .[symptoma.com] spaced nipples Trisomy 9 (usually mosaic) Mental retardation Intrauterine and postnatal growth delay Microcephaly Micrognathia Low-set, malformed ears and other facial anomalies[alpfmedical.info]

  • Short stature-Valvular Heart Disease-Characteristic Facies Syndrome

    Vertebral anomalies include hemivertebra, butterfly vertebrae, and coronal clefts. Supernumerary or absent ribs occur in 20 percent of affected individuals.[dermatologyadvisor.com] spaced nipples Pectus excavatum or pectus carinatum (up to 90% have both, usually pectus carinatum superiorly and pectus excavatum inferiorly) Scoliosis As patients age,[pedclerk.bsd.uchicago.edu] […] hypoplasia, hyperconvex uplifted nails, multiple pigmented nevi, characteristic facies, short 4th metacarpal, high arched palate, or chronic otitis media.” 24 PWS is a rare[cmecorner.com]

  • Congenital Mandibular Hypoplasia

    spaced nipples - cubitus valgus - hyperconvex finger nails - short stature - sexual maturation failure (adrenarche normal, but delayed pubarche, and have premature menopause[quizlet.com] Vertebral abnormalities: hemivertebra or block vertebra, vertebral hypoplasia, absent ribs, short neck. Midline facial cleft.[patient.info] […] finger nails - short stature - sexual maturation failure (adrenarche normal, but delayed pubarche, and have premature menopause (infertile by 2 yo) NORMAL INTELLIGENCE Other[quizlet.com]

  • Renal Malrotation

    Coincidentally, 2 coronal cleft vertebrae are noted.[emedicine.medscape.com] Chest - broad chest, pectus excavatum, inverted, hypoplastic, widely-spaced nipples. Joints - cubitus valgus, congenital hip dislocation.[patient.info] It is characterized by a sagittal cleft. Diastematomyelia is more common in females.[transbiomedicine.com]

  • Absent Thumb - Short Stature - Immunodeficiency Syndrome

    spaced nipples, and webbed neck?[stuvia.com] […] dysplasia Eczema Postaxial polydactyly Severe platyspondyly Hyperconvex fingernails Diaphyseal thickening Subcortical cerebral atrophy Abnormal palate morphology Abnormality[mendelian.co] spaced nipples, puffy hand and feet, dark pigmented naevi, caf -au-lait spots, microcephaly, growth delay, speech delay, severe intellectual impairment, seizures pter qter[chr7.org]

  • Acrorenal Mandibular Syndrome

    spaced nipples - cubitus valgus - hyperconvex finger nails - short stature - sexual maturation failure (adrenarche normal, but delayed pubarche, and have premature menopause[quizlet.com] nail Aplasia of the uterus Upper limb undergrowth Ovarian cyst Shawl scrotum Long fingers Language impairment Abnormal lacrimal duct morphology Focal seizures with impairment[mendelian.co] Congenital diaphragmatic hernia Downslanted palpebral fissures Finger syndactyly Hemivertebrae Hypoplastic scapulae Kyphosis Narrow face Oral cleft Scoliosis Short philtrum[dovemed.com]

  • Zlotogora-Ogur Syndrome

    […] intermamillary distance Wide-spaced nipples Widely spaced nipples Widely-spaced nipples [ more ] 0006610 Wide nasal bridge Broad nasal bridge Broad nasal root Broadened nasal[rarediseases.info.nih.gov] nail Ectrodactyly Hoarse voice Widely spaced teeth Bifid uvula Supernumerary nipple Hypogonadism Abnormality of the ureter Renal agenesis Depressed nasal bridge Abnormality[mendelian.co] […] or high-arched palate, scoliosis, short fifth finger, persistence of fingerpads, radiographic abnormalities of the vertebrae, hands, and hip joints, and recurrent otitis[mendelian.co]

  • Conductive Deafness - Ptosis - Skeletal Anomalies Syndrome

    The vertebrae may have coronal clefts and scoliosis often develops. Generalized metaphyseal dysplasia and delayed bone age are usually present.[disorders.eyes.arizona.edu] General physical examination revealed short stature, delayed milestones, widely spaced nipples, and cubitus vulgus [Figure 4] and [Figure 5].[jclpca.org] Polydactyly in combination with retroflexible thumbs, transverse creases, hyperconvex narrow nails, and flexion of the fingers and hands are characteristic of this syndrome[arthritisresearch.us]

  • Hypotonia-Failure to Thrive-Microcephaly Syndrome

    Large hands/ feet Macrocephaly Hypertelorism Down-slanting palpebral fissure Mild to moderate mental retardation TURNER SYNDROME- Short Stature Webbed neck Broad chest with wide-spaced[paediatricks.com] […] finger nails - short stature - sexual maturation failure (adrenarche normal, but delayed pubarche, and have premature menopause (infertile by 2 yo) NORMAL INTELLIGENCE Other[quizlet.com] (upper back) Platyspondilie thoracal (narrowing of the intervertebral disc spaces in the upper lumbar and lower thoracic spine and clefting of the posterior end plates at[bohring-opitz.org]

  • Deafness-Epiphyseal Dysplasia-Short Stature Syndrome

    CDH Odontoid malformation atlanto-axial instability Scoliosis and kyphosis develops in late childhood early adolescence Other abnormalities associate (TEV, hernia, myopia cleft[flinders.edu.au] Chest - broad chest, pectus excavatum, inverted, hypoplastic, widely-spaced nipples. Joints - cubitus valgus, congenital hip dislocation.[patient.info] […] palate) (Tarda) Flattened vertebrae and inter vertebral discs Posterior spinal hump Back pain at age 5-10 years Proximal femur & humerus minimally involved X-Rays Posterior[flinders.edu.au]

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