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142 Possible Causes for Clenched Hands, Congenital Heart Disease

  • Trisomy 18

    At least 30% of affected fetuses have abnormal extremities (unilateral or bilateral), the most frequent one being clenched hand and radial aplasia.[humpath.com] A prenatal diagnosis of ductal-dependent, complex congenital heart disease was made in a fetus with trisomy 18.[ncbi.nlm.nih.gov] METHODS: A retrospective chart review of patients with trisomy 18 and congenital heart disease from 2005 to 2017 was performed.[ncbi.nlm.nih.gov]

  • Patau Syndrome

    Symptoms of the Disease are Extra fingers, decreased muscle tone, clenched hands, small eyes, small head, scalp defects etc.[omicsonline.org] Most infants with trisomy 13 have congenital heart disease.[nlm.nih.gov] hand with finger overlap, rocker bottom feet, micrognathia, low set ears Image depicting classic appearance of clenched hand with overlapping 2nd and 5th fingers in a newborn[pedclerk.bsd.uchicago.edu]

  • Marfan Syndrome

    Colorado Fetal Care Center Colorectal and Urogenital Care Heart Complex Congenital Heart Disease & Development Clinic Orthopedics Concussion Program Surgery Craniofacial[childrenscolorado.org] […] arachnodactyly protrusion of thumb beyond fist when clenched ( Steinberg sign ) flexion deformity of the 5 th finger pelvis / lower limbs pes planus hallux valgus clubfoot[radiopaedia.org] Steinberg's thumb sign - a flexed thumb grasped within a clenched palm protrudes beyond the ulnar border of that hand.[patient.info]

  • Partial Trisomy 13 in Patau Syndrome

    hands with overlapping fingers decreased muscle tone abnormal forebrain structures holoprosencephaly polydactyly cryptorchidism congenital heart disease "punched out" lesions[medbullets.com] hands (with outer fingers on top of the inner fingers) Close-set eyes -- eyes may actually fuse together into one Decreased muscle tone Extra fingers or toes (polydactyly[documentingreality.com] Skeletal problems: Babies with Patau syndrome may have extra fingers or toes, clenched hands, or misshapen (rocker-bottom) feet.[verywell.com]

  • Pierre Robin Syndrome

    Congenital heart disease occurs in about 20 percent of patients with Pierre Robin syndrome.[ncbi.nlm.nih.gov] Symptoms include cleft lip or palate, clenched hands (with outer fingers on top of the inner fingers), close-set eyes, decreased muscle tone, extra fingers or toes (polydactyl[doi.org] Partial trisomy 11q in a female infant with Robin sequence and congenital heart disease. Cleft Palate Craniofac J. 1992 ; 29: 77 – 79.[doi.org]

  • Crouzon Syndrome

    Second-trimester molecular prenatal diagnosis of sporadic Apert syndrome following sonographic findings of mild ventriculomegaly and clenched hands mimicking trisomy 18.[ncbi.nlm.nih.gov] Child had episodes of cyanosis while crying for which he was evaluated by cardiologist and congenital cyanotic heart diseases were ruled out.[jnaccjournal.org]

  • Apert Syndrome

    Second-trimester molecular prenatal diagnosis of sporadic Apert syndrome following sonographic findings of mild ventriculomegaly and clenched hands mimicking trisomy 18.[eyewiki.aao.org] Apert syndrome (AS) is a rare autosomal dominant disorder characterised by craniosynostosis and limb malformations, and is associated with congenital heart disease and other[ncbi.nlm.nih.gov] Other abnormalities includes central nervous system anomalies, congenital heart diseases, cleft palate, and urogenital diseases.[ncbi.nlm.nih.gov]

  • Atrioventricular Septal Defect

    hands Trisomy 21 21 AVSD Single AV valve Choroid plexus cyst Enlarged nuchal fold Hydronephrosis Trisomy 21 19 AVSD Ventriculomegaly Corpus callosum agenesis Hydrops fetalis[ncbi.nlm.nih.gov] heart disease.[accessmedicine.mhmedical.com] congenital heart disease (ACHD) centres is required.[ncbi.nlm.nih.gov]

  • Ellis-Van Creveld Syndrome

    In 1940 Ellis and van Creveld (2) described 2 more patients with similar congenital anomalies who, in addition, had congenital heart disease.[annals.org] Limitation of hand function, such as the inability to form a clenched fist, is frequently observed.[emedicine.medscape.com] heart disease.[ncbi.nlm.nih.gov]

  • Pediatric Arterial Ischemic Stroke

    Keeping fingers and toes on 1 side of their body clenched in a fist. Using 1 hand much more than the other. This is not common before age 1 in healthy babies.[seattlechildrens.org] Clinical data revealed congenital heart disease with intracardiac thrombus, suggesting that the stenosis was because of embolus.[ahajournals.org] Cardiac disorders including congenital heart disease, patent ductus arteriosus and pulmonary valve atresia.[pediatricstroke.org]

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