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149 Possible Causes for Clenched Hands, Congenital Heart Disease, Dysmorphic Face

  • Patau Syndrome

    Symptoms of the Disease are Extra fingers, decreased muscle tone, clenched hands, small eyes, small head, scalp defects etc.[omicsonline.org] Most infants with trisomy 13 have congenital heart disease.[nlm.nih.gov] hand with finger overlap, rocker bottom feet, micrognathia, low set ears Image depicting classic appearance of clenched hand with overlapping 2nd and 5th fingers in a newborn[pedclerk.bsd.uchicago.edu]

  • Trisomy 18

    At least 30% of affected fetuses have abnormal extremities (unilateral or bilateral), the most frequent one being clenched hand and radial aplasia.[humpath.com] A prenatal diagnosis of ductal-dependent, complex congenital heart disease was made in a fetus with trisomy 18.[ncbi.nlm.nih.gov] METHODS: A retrospective chart review of patients with trisomy 18 and congenital heart disease from 2005 to 2017 was performed.[ncbi.nlm.nih.gov]

  • Marfan Syndrome

    Colorado Fetal Care Center Colorectal and Urogenital Care Heart Complex Congenital Heart Disease & Development Clinic Orthopedics Concussion Program Surgery Craniofacial[childrenscolorado.org] […] arachnodactyly protrusion of thumb beyond fist when clenched ( Steinberg sign ) flexion deformity of the 5 th finger pelvis / lower limbs pes planus hallux valgus clubfoot[radiopaedia.org] Steinberg's thumb sign - a flexed thumb grasped within a clenched palm protrudes beyond the ulnar border of that hand.[patient.info]

  • Pierre Robin Syndrome

    Congenital heart disease occurs in about 20 percent of patients with Pierre Robin syndrome.[ncbi.nlm.nih.gov] Symptoms include cleft lip or palate, clenched hands (with outer fingers on top of the inner fingers), close-set eyes, decreased muscle tone, extra fingers or toes (polydactyl[doi.org] Because growth is altered in the mandible but may not be altered in other parts of the face, a dysmorphism of the features may progress and become more prominent with age[emedicine.medscape.com]

  • Crouzon Syndrome

    Second-trimester molecular prenatal diagnosis of sporadic Apert syndrome following sonographic findings of mild ventriculomegaly and clenched hands mimicking trisomy 18.[ncbi.nlm.nih.gov] Child had episodes of cyanosis while crying for which he was evaluated by cardiologist and congenital cyanotic heart diseases were ruled out.[jnaccjournal.org]

  • Mucopolysaccharidosis 1H

    Limitations in hand function, such as fist clenching and flexion deformities especially in distal interphalangeal joints (DIJ) and ulnar deviation, were common features.[ojrd.biomedcentral.com]

  • Trisomy 9

    hands with thumb adduction and ulnar deviation.[ncbi.nlm.nih.gov] A distinct trisomy 9 syndrome can be recognised with intrauterine growth retardation, short survival, consistent facial dysmorphism, congenital heart disease, and abnormalities[ncbi.nlm.nih.gov] The second fetus showed a dysmorphic face, bilateral cleft lip, hypoplastic corpus callosum, and a Dandy-Walker malformation.[ncbi.nlm.nih.gov]

  • Cornelia De Lange Syndrome

    […] contrast, other features characteristic of isochromosome 18p, namely microstomia, prominent upper lip, pinched nose, asymmetric long face, long and narrow fingers/toes, clenched[jmg.bmj.com] Congenital heart disease (CHD) is not a major criterion of the disease, but it affects many individuals.[ncbi.nlm.nih.gov] Cornelia de Lange syndrome (CdLS) is a rare, congenital syndrome characterized by growth retardation, dysmorphic face, mental retardation and limb reduction defects.[ncbi.nlm.nih.gov]

  • Craniosynostosis

    Second-trimester molecular prenatal diagnosis of sporadic Apert syndrome following sonographic findings of mild ventriculomegaly and clenched hands mimicking trisomy 18.[eyewiki.aao.org] Children with congenital heart disease undergoing noncardiac surgery have an increased risk of perioperative morbidity and cardiac arrest.[ncbi.nlm.nih.gov] Syndromic craniosynostosis is associated with various dysmorphisms involving the face, skeleton, nervous system, and other anomalies and is usually accompanied by developmental[ncbi.nlm.nih.gov]

  • Pseudohypoparathyroidism

    Congenital heart disease and its related symptoms, heart murmur. Speech delay. Abnormal facies: cleft palate, micrognathia, ear abnormalities.[patient.info] […] and third metacarpal in the left hand Figure 3: Hands of an adult with AHO showing knuckle dimples in the clenched fists Figure 4: Feet of a child with AHO showing extreme[hypopara.org.uk] […] bones Figure 1 : Hand of a child with AHO showing short stubby fingers Figure 2: Hands of a child with AHO showing marked shortening of the fourth metacarpal in the right hand[hypopara.org.uk]

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