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130 Possible Causes for Clenched Hands, Congenital Heart Disease, Nail Abnormality

  • Trisomy 18

    At least 30% of affected fetuses have abnormal extremities (unilateral or bilateral), the most frequent one being clenched hand and radial aplasia.[humpath.com] Other common disorders included the single palmar crease (42%) and hypoplastic nails (36%). Radial abnormalities were found in 11 patients (22%).[dx.doi.org] A prenatal diagnosis of ductal-dependent, complex congenital heart disease was made in a fetus with trisomy 18.[ncbi.nlm.nih.gov]

  • Patau Syndrome

    Symptoms of the Disease are Extra fingers, decreased muscle tone, clenched hands, small eyes, small head, scalp defects etc.[omicsonline.org] […] hyperconvex) nails.[rarediseases.org] Most infants with trisomy 13 have congenital heart disease.[nlm.nih.gov]

  • Ellis-Van Creveld Syndrome

    Limitation of hand function, such as the inability to form a clenched fist, is frequently observed.[emedicine.com] Our patient had all the major characteristic features consistent with Ellis-van Creveld syndrome including post-axial polydactyly, teeth and nail abnormalities, congenital[ncbi.nlm.nih.gov] In 1940 Ellis and van Creveld (2) described 2 more patients with similar congenital anomalies who, in addition, had congenital heart disease.[annals.org]

  • Trisomy 9

    hands with thumb adduction and ulnar deviation.[ncbi.nlm.nih.gov] Soft-tissue - clinodactyly, camptodactyly, syndactyly, dystrophic nails.[symptoma.com] A distinct trisomy 9 syndrome can be recognised with intrauterine growth retardation, short survival, consistent facial dysmorphism, congenital heart disease, and abnormalities[ncbi.nlm.nih.gov]

  • Partial Trisomy 13 in Patau Syndrome

    heart disease, blindness, severe mental retardation may complicate survival Please rate topic.[medbullets.com] hand with finger overlap, rocker bottom feet, micrognathia, low set ears Image depicting classic appearance of clenched hand with overlapping 2nd and 5th fingers in a newborn[pedclerk.bsd.uchicago.edu] […] hyperconvex) nails.[rarediseases.org]

  • Apert Syndrome

    Other abnormalities includes central nervous system anomalies, congenital heart diseases, cleft palate, and urogenital diseases.[ncbi.nlm.nih.gov] Second-trimester molecular prenatal diagnosis of sporadic Apert syndrome following sonographic findings of mild ventriculomegaly and clenched hands mimicking trisomy 18.[eyewiki.aao.org] […] phalanx Brachydactyly The nails are contiguous (synonchia) Some people possess subacromial dimples In severe cases, the mobility of the shoulder joint is further limited[syndrome.org]

  • Atrioventricular Septal Defect

    heart disease.[accessmedicine.mhmedical.com] hands Trisomy 21 21 AVSD Single AV valve Choroid plexus cyst Enlarged nuchal fold Hydronephrosis Trisomy 21 19 AVSD Ventriculomegaly Corpus callosum agenesis Hydrops fetalis[ncbi.nlm.nih.gov] ) Difficulty breathing Poor weight gain and growth Heart murmur: the heart sounds abnormal when a doctor listens with a stethoscope Partial atrioventricular canal defects[chop.edu]

  • Disproportionate Short Stature - Ptosis - Valvular Heart Lesions

    Pneumothorax Hand clenching Broad columella Biventricular hypertrophy Poroma Hypoplastic heart Heterogeneous Alopecia Decreased adipose tissue around neck Retrognathia Abnormality[mendelian.co] Diagnosis and Management of Adult Congenital Heart Disease, by Drs.[books.google.com] Speaking 2-word sentences at 31 months Cutaneous abnormalities Keratosis pilaris atrophicansfaciei, Hyperelastic skin, Dystrophic nails Other Predisposition to myeloproliferative[pedclerk.bsd.uchicago.edu]

  • Thumb Deformity - Alopecia - Pigmentation Anomaly Syndrome

    hands, absent radius, webbed 2nd/3rd toes, rocker-bottom feet 50% die in first week of life Only 8% survive beyond 1 yo 1 in 733 (doesn't account for spontaneous abortion[quizlet.com] Nail abnormalities are problems with the color, shape, texture, or thickness of the fingernails or toenails.[medlineplus.gov] THE familial transmission of congenital heart disease and upper-extremity deformities was first reported by Holt and Oram 1 in 1960.[nejm.org]

  • Facioauriculoradial Dysplasia

    hands with overlapping fingers, congenital heart disease, renal anomalies VACTERL association 192350 Sporadic Nonrandom association of anomalies, including vertebral anomalies[docksci.com] […] of the metaphysis Thin skin Waddling gait Arnold-Chiari malformation Laryngomalacia Selective tooth agenesis Narrow mouth Nail dysplasia Limitation of joint mobility Flat[mendelian.co] […] brain defects, inborn errors of metabolism, and congenital heart disease.[books.google.com]

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