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200 Possible Causes for Clenched Hands, Congenital Heart Disease, Polydactyly

  • Patau Syndrome

    hand with finger overlap, rocker bottom feet, micrognathia, low set ears Image depicting classic appearance of clenched hand with overlapping 2nd and 5th fingers in a newborn[pedclerk.bsd.uchicago.edu] Most infants with trisomy 13 have congenital heart disease.[nlm.nih.gov] Patau syndrome has an incidence of 1/10.000-20.000, the clinical diagnosis being suggested by the triad cleft lip and palate, microphthalmia/anophthalmia and postaxial polydactyly[ncbi.nlm.nih.gov]

  • Partial Trisomy 13 in Patau Syndrome

    hands with overlapping fingers decreased muscle tone abnormal forebrain structures holoprosencephaly polydactyly cryptorchidism congenital heart disease "punched out" lesions[medbullets.com] The absence of polydactyly, hernias, urogenital abnormalities, and haemangiomas contrast this condition with both trisomy 13 and duplication of 13q14-22-- qter.[ncbi.nlm.nih.gov] (60%), microcephaly, microphthalmia, cleft lip/palate, postaxial polydactyly (60%), omphalocele, heart defects, and renal anomalies.[clinicaladvisor.com]

  • Trisomy 18

    At least 30% of affected fetuses have abnormal extremities (unilateral or bilateral), the most frequent one being clenched hand and radial aplasia.[humpath.com] A prenatal diagnosis of ductal-dependent, complex congenital heart disease was made in a fetus with trisomy 18.[ncbi.nlm.nih.gov] Amongst 240 Live born babies with trisomy 13, 57% (51-64%) had a cardiac anomaly, 39% (33-46%) had a nervous system anomaly, 30% (24-36%) had an eye anomaly, 44% (37-50%) had polydactyly[ncbi.nlm.nih.gov]

  • Ellis-Van Creveld Syndrome

    In 1940 Ellis and van Creveld (2) described 2 more patients with similar congenital anomalies who, in addition, had congenital heart disease.[annals.org] Polydactyly is the most frequent skeletal anomaly.[ncbi.nlm.nih.gov] Limitation of hand function, such as the inability to form a clenched fist, is frequently observed.[emedicine.com]

  • Apert Syndrome

    Second-trimester molecular prenatal diagnosis of sporadic Apert syndrome following sonographic findings of mild ventriculomegaly and clenched hands mimicking trisomy 18.[eyewiki.aao.org] Apert syndrome (AS) is a rare autosomal dominant disorder characterised by craniosynostosis and limb malformations, and is associated with congenital heart disease and other[ncbi.nlm.nih.gov] We report a patient with a rare form of Apert syndrome with polydactyly.[ncbi.nlm.nih.gov]

  • Pierre Robin Syndrome

    Congenital heart disease occurs in about 20 percent of patients with Pierre Robin syndrome.[ncbi.nlm.nih.gov] Involvement of the musculoskeletal system are as follows: Upper Limb: Dysplastic phalanges Polydactyly Clinodactyly Hypersensitive joints Oligodactyly Lower extremities Foot[syndrome.org] Symptoms include cleft lip or palate, clenched hands (with outer fingers on top of the inner fingers), close-set eyes, decreased muscle tone, extra fingers or toes (polydactyl[doi.org]

  • Marfan Syndrome

    Colorado Fetal Care Center Colorectal and Urogenital Care Heart Complex Congenital Heart Disease & Development Clinic Orthopedics Concussion Program Surgery Craniofacial[childrenscolorado.org] […] calcification-moth-eaten skeletal dysplasia Microtubules Kinesin Charcot–Marie–Tooth disease 2A Hereditary spastic paraplegia 10 Dynein Primary ciliary dyskinesia Short rib-polydactyly[en.wikipedia.org] […] arachnodactyly protrusion of thumb beyond fist when clenched ( Steinberg sign ) flexion deformity of the 5 th finger pelvis / lower limbs pes planus hallux valgus clubfoot[radiopaedia.org]

  • Cornelia De Lange Syndrome

    […] contrast, other features characteristic of isochromosome 18p, namely microstomia, prominent upper lip, pinched nose, asymmetric long face, long and narrow fingers/toes, clenched[jmg.bmj.com] Congenital heart disease (CHD) is not a major criterion of the disease, but it affects many individuals.[ncbi.nlm.nih.gov] , and intellectual disabilities) 759.89 Barth 759.89 basal cell nevus 759.89 Beckwith (-Wiedemann) 759.89 Biedl-Bardet (obesity, polydactyly, and intellectual disabilities[icd9data.com]

  • Facioauriculoradial Dysplasia

    […] brain defects, inborn errors of metabolism, and congenital heart disease.[books.google.com] The radial defects observed with less frequency were thumb agenesis, preaxial polydactyly, and triphalangeal thumb. [5] In our case left-side preaxial polydactyly was observed[jfmpc.com] hands with overlapping fingers, congenital heart disease, renal anomalies VACTERL association 192350 Sporadic Nonrandom association of anomalies, including vertebral anomalies[docksci.com]

  • Atrioventricular Septal Defect

    hands Trisomy 21 21 AVSD Single AV valve Choroid plexus cyst Enlarged nuchal fold Hydronephrosis Trisomy 21 19 AVSD Ventriculomegaly Corpus callosum agenesis Hydrops fetalis[ncbi.nlm.nih.gov] heart disease.[accessmedicine.mhmedical.com] Abstract We report two more patients with the association of postaxial polydactyly and atrioventricular septal defects.[ncbi.nlm.nih.gov]

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