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114 Possible Causes for Clenched Hands, Congenital Heart Disease, Short Stature in Children

  • Trisomy 18

    At least 30% of affected fetuses have abnormal extremities (unilateral or bilateral), the most frequent one being clenched hand and radial aplasia.[humpath.com] A prenatal diagnosis of ductal-dependent, complex congenital heart disease was made in a fetus with trisomy 18.[ncbi.nlm.nih.gov] METHODS: A retrospective chart review of patients with trisomy 18 and congenital heart disease from 2005 to 2017 was performed.[ncbi.nlm.nih.gov]

  • Cornelia De Lange Syndrome

    […] contrast, other features characteristic of isochromosome 18p, namely microstomia, prominent upper lip, pinched nose, asymmetric long face, long and narrow fingers/toes, clenched[jmg.bmj.com] Congenital heart disease (CHD) is not a major criterion of the disease, but it affects many individuals.[ncbi.nlm.nih.gov] Cornelia de Lange Syndrome Definition [ edit ] Cornelia de Lange Syndrome is a rare developmental malformation syndrome characterized by mental retardation, short stature,[en.wikibooks.org]

  • Crouzon Syndrome

    Second-trimester molecular prenatal diagnosis of sporadic Apert syndrome following sonographic findings of mild ventriculomegaly and clenched hands mimicking trisomy 18.[ncbi.nlm.nih.gov] Child had episodes of cyanosis while crying for which he was evaluated by cardiologist and congenital cyanotic heart diseases were ruled out.[jnaccjournal.org] A five-year-old boy with Crouzon Syndrome, short stature, and delayed bone age was found to have partial growth hormone deficiency.[ncbi.nlm.nih.gov]

  • Mucopolysaccharidosis 1H

    Affected children have a short stature and suffer from hepatosplenomegaly, a condition characterized by an enlarged liver and spleen.[patienthelp.org] Limitations in hand function, such as fist clenching and flexion deformities especially in distal interphalangeal joints (DIJ) and ulnar deviation, were common features.[ojrd.biomedcentral.com] Many children develop a short body trunk and a maximum stature of less than 4 feet.[day2dayparenting.com]

  • Marfan Syndrome

    […] arachnodactyly protrusion of thumb beyond fist when clenched ( Steinberg sign ) flexion deformity of the 5 th finger pelvis / lower limbs pes planus hallux valgus clubfoot[radiopaedia.org] Colorado Fetal Care Center Colorectal and Urogenital Care Heart Complex Congenital Heart Disease & Development Clinic Orthopedics Concussion Program Surgery Craniofacial[childrenscolorado.org] Common referrals include short stature, osteopenia and/or multiple fractures, and skeletal abnormalities.[genetics.medicine.iu.edu]

  • Disproportionate Short Stature - Ptosis - Valvular Heart Lesions

    Pneumothorax Hand clenching Broad columella Biventricular hypertrophy Poroma Hypoplastic heart Heterogeneous Alopecia Decreased adipose tissue around neck Retrognathia Abnormality[mendelian.co] Diagnosis and Management of Adult Congenital Heart Disease, by Drs.[books.google.com] Most children with short stature have normal variants such as familial short stature, constitutional delay of growth and puberty, or idiopathic short stature.[aafp.org]

  • Arthrogryposis Multiplex Congenita

    The ultrasound features related to the "lack of movement" included limb abnormalities (multiple contractures, clenched hands, and clubbed feet), short umbilical cord, polyhydramnios[ncbi.nlm.nih.gov] Six patients had associated congenital heart disease which caused death in five. One patient was mentally retarted.[pediatrics.aappublications.org] Antenatal ultrasound may additionally show direct evidence of contractures such as: abnormal limb/extremity positioning clenched hands knotted fingers persistently extended[radiopaedia.org]

  • Apert Syndrome

    Second-trimester molecular prenatal diagnosis of sporadic Apert syndrome following sonographic findings of mild ventriculomegaly and clenched hands mimicking trisomy 18.[eyewiki.aao.org] Other abnormalities includes central nervous system anomalies, congenital heart diseases, cleft palate, and urogenital diseases.[ncbi.nlm.nih.gov] Children with Apert syndrome may have mental deficiencies, short stature, hearing impairment, frequent ear infections, prominent and/or bulging eyes, a large or late-closing[consultant360.com]

  • Atrioventricular Septal Defect

    hands Trisomy 21 21 AVSD Single AV valve Choroid plexus cyst Enlarged nuchal fold Hydronephrosis Trisomy 21 19 AVSD Ventriculomegaly Corpus callosum agenesis Hydrops fetalis[ncbi.nlm.nih.gov] heart disease.[accessmedicine.mhmedical.com] Children have a short stature and weight deficit, signs of congestive heart failure, dyspnea, fatigue, recurrent lung infections.[doctortipster.com]

  • Ellis-Van Creveld Syndrome

    Limitation of hand function, such as the inability to form a clenched fist, is frequently observed.[emedicine.com] In 1940 Ellis and van Creveld (2) described 2 more patients with similar congenital anomalies who, in addition, had congenital heart disease.[annals.org] All three girls had short stature, narrow rib cage, polydactyly and nail hypoplasia. The first daughter died in early infancy in respiratory failure.[ncbi.nlm.nih.gov]

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