Clinical Heterogeneity Causes & Reasons

Neu starten

Ad Html Headline Ad Text Headline

Ad Label Ad Html Description Ad Text Description

Determine your risk of now. Restart test

Caution! In case of an emergency:

Seek emergency care

Caution! In case of an emergency: Seek emergency care

Hi, I'm Symptoma.

Clinical Heterogeneity Symptom Checker: Possible causes include Leigh's Disease. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.

For full functionality of this site it is necessary to enable JavaScript.

How to enable JavaScript?

Possible Causes

Leigh's Disease

They are clinically heterogeneous, can occur at any age, and generally manifest with a wide array of clinical symptoms, usually being defined as multisystem diseases. [neurohic.com]

This disorder has been proven to be clinically and genetically heterogeneous. [frontiersin.org]

CIII deficiencies are rare and manifest heterogeneous clinical presentations. [ncbi.nlm.nih.gov]

Show info

Common Cold

The team did not perform a summary meta-analysis due to clinical heterogeneity. No serious adverse event (AE) occurred in either the treatment or the control groups. [ncbi.nlm.nih.gov]

heterogeneity of the studies we refrained from pooling for the main analysis. [ncbi.nlm.nih.gov]

The phylogenetic diversity we describe at the whole-genome level is consistent with the clinical heterogeneity of HRV infections in humans ( 1, 3, 4 ), although mapping specific [ncbi.nlm.nih.gov]

Show info

Early-Onset Cerebellar Ataxia

The data suggest that EOCA may be genetically and clinically heterogeneous. [doi.org]

Clinical and genetic heterogeneity in early onset cerebellar ataxia with retained tendon reflexes. [doi.org]

Show info

Tricho-Dento-Osseous Syndrome

Clinical heterogeneity in the tricho-dento-osseous syndrome. Human Genetics, 64 (2), 116-121. [scholars.uthscsa.edu]

Clinical heterogeneity in the tricho-dento-osseous syndrome. / Quattromani, F.; Shapiro, S. D.; Young, R. S.; Jorgenson, R. J.; Parker, J. W.; Blumhardt, R.; Reece, R. [scholars.uthscsa.edu]

@article{f83bae0580714d76b86e1ff3cc5f55b3, title "Clinical heterogeneity in the tricho-dento-osseous syndrome", abstract "The tricho-dento-osseous syndrome (TDO syndrome) [scholars.uthscsa.edu]

Show info

Nemaline Myopathy

PURPOSE: Nemaline myopathy (NM) is a clinical heterogeneous congenital myopathy characterized by the presence of subsarcolemmal or cytoplasmic rod-like structures that call [ncbi.nlm.nih.gov]

Nemaline myopathy is a clinically heterogeneous congenital myopathy caused by mutations in at least 6 genes related to thin filaments. [ncbi.nlm.nih.gov]

Nemaline myopathy (NM) is a genetically and clinically heterogenous muscle disorder, which is myopathologically characterized by nemaline bodies. [ncbi.nlm.nih.gov]

Show info

Acute Bronchitis

These were clinically heterogeneous, so we used a random‐effects meta‐analysis. [doi.org]

clinical heterogeneity among trials (see Description of studies ). [doi.org]

Assessment of heterogeneity The studies included in this review were clinically heterogeneous and provided limited data, so we undertook no meta‐analysis. [doi.org]

Show info

Bronchitis

These were clinically heterogeneous, so we used a random‐effects meta‐analysis. [doi.org]

clinical heterogeneity among trials (see Description of studies ). [doi.org]

BACKGROUND: COPD is a heterogeneous disease composed by two main phenotypes: bronchitis (COPDb) and emphysema (COPDe) with different clinical presentation, physiology, imaging [ncbi.nlm.nih.gov]

Show info

Pure Hereditary Spastic Paraplegia

Hereditary spastic paraplegias (HSP) are genetically and clinically heterogeneous neurodegenerative disorders. [ncbi.nlm.nih.gov]

Abstract Hereditary spastic paraplegia is a clinically and genetically heterogeneous disorder characterized by progressive spasticity of the lower limbs. [ncbi.nlm.nih.gov]

BACKGROUND: Hereditary spastic paraplegia (HSP) is a clinically and genetically heterogeneous disorder characterized by a progressive weakening and spasticity of the lower [ncbi.nlm.nih.gov]

Show info

Hereditary Spastic Paraplegia

From Wikidata Jump to navigation Jump to search genetically and clinically heterogeneous group of neurodegenerative disorders characterized by progressive spasticity and hyperreflexia [wikidata.org]

This case confirms the high genetic and clinical heterogeneity associated with SPG11 mutations. [ncbi.nlm.nih.gov]

Abstract AIM: Hereditary spastic paraplegia (HSP) are a genetically and clinically heterogeneous group of disorders. [ncbi.nlm.nih.gov]

Show info

Acute Gastroenteritis

There was significant heterogeneity among included studies with regards to their research question, study design, and baseline clinical characteristics (i.e., age) of the [frontiersin.org]

This finding highlights the importance of limiting the duration of IVR in children with AGE to the minimum required by promptly resuming ORT as soon as clinically appropriate [frontiersin.org]

Show info

Generalized Epilepsy with Febrile Seizures Plus

The affected GEFS( ) patients in this family displayed significant inter-family clinical heterogeneity. [ncbi.nlm.nih.gov]

Show info

Vitamin B12 Deficiency

We did not perform meta-analyses due to the small number of included trials and substantial clinical heterogeneity. Three RCTs met our inclusion criteria. [ncbi.nlm.nih.gov]

We did not perform meta-analyses due to the small number of included trials and substantial clinical heterogeneity. Main results: Three RCTs met our inclusion criteria. [cochrane.org]

Show info

Mitochondrial DNA Depletion Syndrome

Homepage Rare diseases Search Search for a rare disease Mitochondrial DNA depletion syndrome Disease definition The mitochondrial DNA (mtDNA) depletion syndrome (MDS) is a clinically [orpha.net]

Abstract Mitochondrial DNA (mtDNA) depletion syndromes (MDS) are a genetically and clinically heterogeneous group of autosomal recessive disorders that are characterized by [ncbi.nlm.nih.gov]

Mitochondrial DNA depletion syndrome (MDS) is a clinically heterogeneous group of mitochondrial disorders characterised by a quantitative reduction of the mitochondrial DNA [ncbi.nlm.nih.gov]

Show info

Upper Respiratory Infection

[…] contribute to clinical heterogeneity. [doi.org]

Assessment of heterogeneity The studies included in this review were clinically heterogeneous and provided limited data, so we undertook no meta‐analysis. [doi.org]

The included studies were inevitably clinically heterogeneous in many aspects. [bmj.com]

Show info

Progressive Supranuclear Palsy

heterogeneity in neurodegenerative disorders. [ncbi.nlm.nih.gov]

The present study also demonstrated that the clinical features of PSP may change dramatically according to the disease stage. [ncbi.nlm.nih.gov]

Our observations suggest that coexisting PSP pathology may be an important factor contributing to the clinical heterogeneity in PD and a potential confounder in diagnosis. [ncbi.nlm.nih.gov]

Show info

Hoyeraal-Hreidarsson Syndrome

Clinical heterogeneity in a family with DKC1 mutation, dyskeratosis congenita and Hoyeraal-Hreidarsson syndrome in first cousins. Pediatric Reports, 9 (3). [pagepress.org]

Show info

Acute Alcohol Intoxication

Clinical manifestations are heterogeneous and involve different organs and apparatuses, with behavioral, cardiac, gastrointestinal, pulmonary, neurological, and metabolic [ncbi.nlm.nih.gov]

Abstract Acute alcohol intoxication is a clinically harmful condition that usually follows the ingestion of a large amount of alcohol. [ncbi.nlm.nih.gov]

Leibowitz, Neurochemical Heterogeneity of Rats Predicted by Different Measures to be High Ethanol Consumers, Alcoholism: Clinical and Experimental Research, 37, s1, (E141- [doi.org]

Show info

Urinary Tract Infection

Assessment of heterogeneity As no studies were included, we were unable to assess clinical heterogeneity. [doi.org]

However, in light of the heterogeneity of clinical study designs and the lack of consensus regarding the dosage regimen and formulation to use, cranberry products cannot be [ncbi.nlm.nih.gov]

We compared trials to assess and investigate the likelihood of important clinical heterogeneity. [doi.org]

Show info

Viral Lower Respiratory Infection

[…] than the exception in severe clinical presentations of infectious diseases. [pnas.org]

This hypothesis is in line with several recent publications ( 34 – 37 ), which suggest that incomplete penetrance and genetic heterogeneity are likely to be the rule rather [pnas.org]

Show info

Aggressive Systemic Mastocytosis

Mastocytosis is a clinically heterogenous disease characterized by mast cell hyperplasia in skin, bone marrow and/or visceral organs. [ncbi.nlm.nih.gov]

Lange M, Nedoszytko B, Gorska A, Zawrocki A, Sobjanek M, Kozlowski D.Mastocytosis in children and adults: clinical disease heterogeneity. [rarediseases.org]

[…] presentations are heterogeneous. [symptoma.com]

Show info

Viral Upper Respiratory Tract Infection

The included studies were inevitably clinically heterogeneous in many aspects. [bmj.com]

Show info

Vitamin D Deficiency

Generalized convulsions in the afebrile infant represent a serious and etiopathogenically very heterogeneous problem. [ncbi.nlm.nih.gov]

There were insufficient studies available to complete an analysis of publication bias; however, a search of clinical trials registries was completed to assess the number of [doi.org]

[…] given orally over a period of two weeks.The treatment resulted in complete stabilization of the infant's condition and rapid improvement in laboratory, radiological and clinical [ncbi.nlm.nih.gov]

Show info

Distal Spinal Muscular Atrophy

heterogeneities were observed in patients with the DCTN1 mutation. [ncbi.nlm.nih.gov]

However, clinical heterogeneities were observed between the present and previously reported patients. [spandidos-publications.com]

Abstract The distal hereditary motor neuropathies (distal HMN) are clinically and genetically heterogeneous and are subdivided in seven subtypes according to the mode of inheritance [ncbi.nlm.nih.gov]

Show info

Constipation

Assessment of heterogeneity Clinical heterogeneity was assessed by comparing the distribution of important participant factors (age, sex) between trials and trial factors [doi.org]

Upon statistically significant heterogeneity, the included studies were examined for sources of both clinical and methodological heterogeneity. [dx.doi.org]

Where the interventions were the same or similar enough, we synthesized results in meta‐analysis if there was no important clinical heterogeneity. [doi.org]

Show info

Congenital Muscular Dystrophy

Congenital myasthenic syndrome shows a wide clinical heterogeneity. [ncbi.nlm.nih.gov]

Sequencing individual genes by Sanger sequencing is a time-consuming and costly approach to resolve clinically heterogeneous genetic disorders. [ncbi.nlm.nih.gov]

Congenital muscular dystrophies are a genetically and clinically heterogeneous group of disorders typically characterized by weakness and dystrophic pattern on muscle biopsy [dnatesting.uchicago.edu]

Show info

Cerulean Cataract

Due to clinical heterogeneity, it is not always possible to classify specific families based on the appearance and natural history of the lens opacities alone. [disorders.eyes.arizona.edu]

About 23% are familial but even among these there is considerable genetic and clinical heterogeneity that confounds the nosology despite notable recent progress in genotyping [disorders.eyes.arizona.edu]

Mutations in the same gene also cause an allelic disorder designated nonnuclear polymorphic congenital cataracts or PCC ( 601286 ), which may simply be clinical heterogeneity [disorders.eyes.arizona.edu]

Show info

Maturity-Onset Diabetes of the Young

Maturity-onset diabetes of the young (MODY) is a clinically heterogeneous group of monogenic disorders characterized by autosomal dominant inheritance of young-onset, non-insulin-dependent [ncbi.nlm.nih.gov]

Maturity-onset diabetes of the young (MODY) is a genetically and clinically heterogeneous type of diabetes mellitus, characterized by early onset (often before 25 years of [ncbi.nlm.nih.gov]

MODY (maturity-onset diabetes of the young) is a genetically linked group of clinically heterogeneous subtypes of diabetes. [ncbi.nlm.nih.gov]

Show info

Acute Cystitis

Assessment of heterogeneity As no studies were included, we were unable to assess clinical heterogeneity. [doi.org]

heterogeneity between the trials; lack of presentation of baseline data so that comparability can be assessed; use of unvalidated outcome measures or reporting outcomes in [doi.org]

[…] efficacy and microbiological efficacy rates should not necessarily be compared across agents, because study design, efficacy definition, therapy duration, and other factors are heterogeneous [dx.doi.org]

Show info

Kallmann Syndrome

We describe herein the clinical heterogeneity in three affected brothers who carry a large deletion (exons 3-13) in KAL-1. [ncbi.nlm.nih.gov]

However, his mother and younger brother did not show clinical features of KS, potentially associated with the clinical heterogeneity of KS. [journals.lww.com]

heterogeneity in three siblings carrying an intragenic deletion of the KAL-1 gene. 6 61 54 Massin N...Touraine P 12727945 2003 11 Loss-of-function mutations in FGFR1 cause [malacards.org]

Show info

Insect Bite

Abstract Primary immunodeficiency diseases (PID) is a heterogeneous group of disorders caused by genetic defects of the immune system, which manifests clinically as recurrent [ncbi.nlm.nih.gov]

Affiliate of the World Universities Network, New York, NY, United States. 12 Department of Paediatrics, Imperial College London, London, United Kingdom. 13 Solov'ev Research and Clinical [ncbi.nlm.nih.gov]

Show info

⚕ Symptoma®️ is a digital health assistant but no replacement for the opinion and judgement of medical professionals. By using this website you fully understand and accept that it shall not be used as a diagnostic system for decision-making. It absolutely must not be used to obtain, replace or overrule a clinical diagnosis by a healthcare professional. It is always for the medical professional to make the final diagnosis. The medical information provided on this website is of a general nature and can not substitute for the advice of a medical professional (for example, a qualified doctor or physician)! Information from the internet could and should NOT be solely used to offer or render a medical opinion or otherwise engage in the practice of medicine.