Clinodactyly: Causes & Reasons

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Possible Causes for clinodactyly

Cardiodysrhythmic Potassium-Sensitive Periodic Paralysis

Figure (A) Fifth digit clinodactyly and (B) syndactyly of the toes 2 and 3, highly suggestive of Andersen-Tawil syndrome. [scielo.br]

This condition is inherited in an autosomal dominant pattern. 0000337 Bulbous nose 0000414 Cleft palate Cleft roof of mouth 0000175 Clinodactyly of the 5th finger Permanent [rarediseases.info.nih.gov]

[…] leading to predisposition to sudden cardiac death) and characteristic physical features: short stature, scoliosis, low-set ears, hypertelorism, broad nasal root, micrognathia, clinodactyly [orpha.net]

Fibrodysplasia Ossificans Progressiva

Occasional features include short thumbs, fifth finger clinodactyly, malformed cervical vertebrae and mild mental retardation. [ncbi.nlm.nih.gov]

Other features of FOP can include short thumbs, fifth finger clinodactyly (pinkie curved toward the thumb), malformed cervical (neck) vertebrae, short broad neck of the femur [medicinenet.com]

(c, d) Images of hands and feet showing clinodactyly and hallux valgus deformities. [iofbonehealth.org]

Russell-Silver Syndrome

[…] short stature of prenatal onset, triangular facies, asymmetry, variations in the pattern of sexual development, and other abnormalities, such as cafe-au-lait pigmentation, clinodactyly [ncbi.nlm.nih.gov]

[…] describe a 10-year-old Taiwanese RSS girl with prenatal and postnatal growth retardation, relative macrocephaly, a triangular face, frontal bossing, and mild fifth finger clinodactyly [ncbi.nlm.nih.gov]

However, in children between 2 and 10 years of age, the concordance of significantly delayed maturation, clinodactyly, fifth middle or distal phalangeal hypoplasia, ivory [ncbi.nlm.nih.gov]

Aarskog-Scott Syndrome

Findings on the extremities include joint hyperextensibility, short and broad hands, interdigital webbing, a short fifth finger, clinodactyly and broad feet with bulbous toes [ncbi.nlm.nih.gov]

[…] hypertelorism, short nose with anteverted nares, maxillary hypoplasia, a crease below the lower lip, mild interdigital webbing with short and broad hands, short fifth finger with clinodactyly [ncbi.nlm.nih.gov]

[…] nares Nasal tip, upturned Upturned nose Upturned nasal tip Upturned nostrils [ more ] 0000463 Broad forehead Increased width of the forehead Wide forehead [ more ] 0000337 Clinodactyly [rarediseases.info.nih.gov]

Tel Hashomer Camptodactyly Syndrome

Winging scapulae, scoliosis, syndactyly and clinodactyly are commonly observed. The affected patients usually have normal mental development. [orpha.net]

Patients hands with brachydactyly, camptodactyly of mid- dle fingers, clinodactyly of fifth fingers, and minimal soft tissue syndac- tYlY. Fig. 6. [vdocuments.mx]

He also had proximal cutaneous syndactyly of all fingers, clinodactyly of the fifth fingers, brachydactylous thumbs, and tapering of fingers. [vdocuments.site]

Kleiner Holmes Syndrome

[…] of the skeletal system and Clinodactyly that can help you solving undiagnosed cases. [mendelian.co]

Affiliated tissues include bone, and related phenotypes are sandal gap and clinodactyly of the 5th finger [malacards.org]

Preaxial Polysyndactyly Orphanet ( Visit this link ) Clinical signs Autosomal recessive inheritance Metatarsus adductus Wide space between 1st-2nd toes Broad/bifid great toe Clinodactyly [myorthopaedicsurgeon.com]

Mesoaxial Synostotic Syndactyly with Phalangeal Reduction

[…] characterized by mesoaxial osseous synostosis at a metacarpal level, reduction of one or more phalanges, hypoplasia of distal phalanges of preaxial and postaxial digits, clinodactyly [uniprot.org]

The limb findings include mesoaxial reduction of the fingers, synostoses of the third and fourth metacarpals with associated single phalanges, fifth finger clinodactyly, and [ncbi.nlm.nih.gov]

[…] syndactyly of the 3rd and 4th fingers with synostoses of the corresponding metacarpals and associated single phalanges, syndactyly of the 2nd and 3rd toes and 5th finger clinodactyly [rarediseases.info.nih.gov]

Banki Syndrome

Orthopedics OCOSH Classification Hand Disorders and Deformities Congenital Hand Deformities Failure of differentiation Clinodactyly Internet resources relating to Clinodactyly [orthopaedicweblinks.com]

As such no treatment is required for clinodactyly. [m.athena.targetwoman.com]

1228Disease definitionBanki syndrome is a synostosis syndrome, reported in a single Hungarian family in which members of 3 generations showed lunotriquetral synostosis, clinodactyly [malacards.org]

OSLAM Syndrome

Clinodactyly The picture above illustrates a severe case of this condition. [en.wikipedia.org]

[…] for information on rare diseases and orphan drugs.Orpha Number: 2760Disease definitionOSLAM syndrome is characterised by the association of osteosarcoma, limb anomalies (clinodactyly [malacards.org]

[…] portal for information on rare diseases and orphan drugs.Orpha Number: 2760DefinitionOSLAM syndrome is characterised by the association of osteosarcoma, limb anomalies (clinodactyly [malacards.org]

Hand-Foot-Genital Syndrome

We report a child born with bilateral postaxial syndactyly of the feet and bilateral fifth finger clinodactyly. [ncbi.nlm.nih.gov]

[…] thumb and fifth finger Hypoplastic thenar eminences Medial deviation of the great toe (hallux varus), a useful diagnostic sign when present Small great toenail Fifth-finger clinodactyly [en.wikipedia.org]

Haploinsufficiency for HOXA13 in humans causes Hand-foot-genital syndrome (HFGS), which is characterized by symmetric preaxial deficiency of the hands and feet, second and fifth finger clinodactyly [oxfordindex.oup.com]

Oculodentodigital Dysplasia

The proband suffered with extensive enamel hypoplasia, polysyndactyly and clinodactyly of the 3rd-5th fingers, microphthalmia, and unique facial characteristics of ODDD. [ncbi.nlm.nih.gov]

The syndrome is characterized by abnormal facial features, central nervous system involvement, syndactyly and clinodactyly of fourth and fifth fingers, dry and lusterless [ncbi.nlm.nih.gov]

The characteristic features include a typical face, premature loss of primary teeth and odontodysplasia of permanent teeth, clinodactyly, ocular signs, and CNS involvement [ncbi.nlm.nih.gov]

Brachydactyly

Wertelecki, M.D.) see finger malformations namely short tips and nails (brachydactyly), clinodactyly (deviation) of the third finger. [ceo.medword.net]

He had short little, index, and middle fingers, long ring fingers, and clinodactyly of the little finger. He also had symmetrical brachydactyly of both feet. [ncbi.nlm.nih.gov]

Figure 7 Hands of 103, one of the indeterminate group, showing small hands but no disproportion or clinodactyly. [jmg.bmj.com]

Autosomal-Recessive Robinow Syndrome

Aplasia/Hypoplasia involving the metacarpal bones ; Autosomal recessive inheritance ; Bifid distal phalanx of toe ; Bifid tongue ; Brachydactyly ; Broad thumb ; Broad toe ; Clinodactyly [mousephenotype.org]

External references: 1 OMIM reference - 1 MeSH reference: C535863 Very frequent - Anteverted nares / nostrils - Autosomal recessive inheritance - Broad nose / nasal bridge - Clinodactyly [csbg.cnb.csic.es]

[…] facial features (hypertelorism, midface hypoplasia, large nasal bridge, short upturned nose, and anteverted nares), mesomelic limb shortening, as well as brachydactyly, clinodactyly [orpha.net]

Polydactyly of a Biphalangeal Thumb

Observe also mesopha- duplication of the distal phalanx of the thumb, bifid proximal langism with clinodactyly of the 5th finger. [rrnursingschool.biz]

[…] hypotonia, brachycephaly, upslanting palpebral ï ssures, ï at nasal bridge, low-set ears, a single transverse palmar crease in the right hand, bilateral ï fth ï nger clinodactyly [deepdyve.com]

The appearance can differ widely; the thumb can be a longer thumb, it can be deviated in the radio-ulnar plane ( clinodactyly ), thumb strength can be diminished. [en.wikipedia.org]

BOD Syndrome

They had shortness and clinodactyly of the 5th fingers, aplasia or hypoplasia of the distal phalanges of 5th fingers, short medial phalanges of the 2nd and 5th fingers, hypoplasia [ncbi.nlm.nih.gov]

[…] the wall separating the top two chambers of the heart Hole in heart wall separating two upper heart chambers [ more ] 0001631 Brachycephaly Short and broad skull 0000248 Clinodactyly [rarediseases.info.nih.gov]

Dubowitz Syndrome

Further findings include hyperactivity, eczema, cryptorchidism in the affected males, and brachy-clinodactyly of the fifth fingers. [ncbi.nlm.nih.gov]

Skeletal abnormalities in DS include sacral dimple, and clinodactyly (5th fingers), with cutaneous syndactyly of toes or fingers. [orpha.net]

Skeletal issues can be delayed bone age, fifth finger clinodactyly, two/three toe syndactyly, and pes planus. Some are very prone to eczema or have severe allergies. [dubowitzsyndrome.net]

Pseudoaminopterin Syndrome

[…] of both 4th and 5th fingers; hypoplasia of the 4th metacarpal and clinodactyly of the 4th and 5th toes; overlap of the second over the third toe; bilateral hip luxation; [ncbi.nlm.nih.gov]

[…] hypertelorism, palpebral fissure anomalies, micrognathia cleft lip and/or high arched palate and small and low set/rotated ears) and limb ( brachydactyly, syndactyly and clinodactyly [rarediseases.info.nih.gov]

[…] hypertelorism, palpebral fissure anomalies, micrognathia cleft lip and/or high arched palate and small and low set/rotated ears.Limb anomalies include brachydactyly, syndactyly and clinodactyly [ncbi.nlm.nih.gov]

Brachydactyly of Fingers

The finger deviation is a type of clinodactyly as I have previously discussed. [congenitalhand.wustl.edu]

CLINODACTYLY Image 19 Clinodactyly of the 5th finger of the hand. Image 20 Photo 1 and 2: Hand with radial deviation of the 5 finger and cubital deviation of the 4 . [en.atlaseclamc.org]

Camptodactyly/Clinodactyly (bent digits) – Treatment Camptodactyly and clinodactyly are two congenital conditions causing bent fingers that are not passively correctible. [baysideplasticsurgery.com.au]

XXXXY Syndrome

A two month-old boy with intrauterine growth restriction (IUGR) and low birth weight, facial dysmorphism, clinodactyly in feet, microphallus, and right undescendent testis [ncbi.nlm.nih.gov]

In addition, almost all patients had muscular hypotonia, radioulnar synostosis, white matter anomalies, fifth-finger clinodactyly, recurrent respiratory infections in early [ncbi.nlm.nih.gov]

The patient had pulmonary stenosis as well as mental retardation, hypogonadism, fifth finger and toe clinodactyly, genu valgus, pes cavus and mandibular prognathism. [jstage.jst.go.jp]

Gorlin-Psaume Syndrome

[…] orpostaxiaipolydactyly;brachydactyly;clinodactyly;syndactyiyPreaxialpoiydactylyCerebellaranomalies;Dandy-WalkeranomalyAutosomalrecessiveOFDS 7(Whelansyndrome)Highly arched [docslide.us]

[…] micrognathia, downslanting palpebral fissures), abnormal hair/alopecia, evanescent facial milia, digital malformations in about 88% (brachydactyly, syndactyly, 5th finger clinodactyly [orpha.net]

Other possible features are syndactyly or clinodactyly and glaucoma. Simpson-Golabi-Behmel Syndrome: Rare X-linked recessive prenatal and postnatal overgrowth ... [accessanesthesiology.mhmedical.com]

3M Syndrome Type 1

Clinodactyly is a frequent finding in SRS and persists in the older age group. [omicsonline.org]

[…] flattening of the forehead due to fusion of the coronal sutures, narrowed interorbital distance, elbow dysplasia, shortened ulna, pseudo-epiphyses of the second metacarpal bone, clinodactyly [ncbi.nlm.nih.gov]

They all showed numerous dysmorphisms, such as triangular face with prominent forehead, large eyes, depressed nasal bridge, thin upper lip, short neck, and bilateral clinodactyly [cags.org.ae]

Craniofrontonasal Dysplasia

[…] lip and/or palate, high arched palate), skeletal anomalies (clavicle pseudoarthrosis, coronal craniosynostosis, various digital and limb anomalies including syndactyly, clinodactyly [orpha.net]

[…] defect of the nose Abnormality of the clavicle Abnormality of the palate Abnormality of the shoulder Abnormality of the teeth Brachydactyly syndrome Camptodactyly of finger Clinodactyly [familydiagnosis.com]

Clinodactyly of both the fifth toe was obvious [Figure 1c]. Fingers of the hands were long with relatively broad thumb. [mjdrdypu.org]

Robinow Syndrome

It is characterized by mesomelic brachymelia, hemivertebrae, dysmorphic facies, genital hypoplasia, micropenis, clinodactyly, camptodactly, hypoplastic nails and moderate [ncbi.nlm.nih.gov]

[…] syndrome were hypertelorism, nasal features (large nasal bridge, short upturned nose, and anteverted nares), midface hypoplasia, mesomelic limb shortening, brachydactyly, clinodactyly [ncbi.nlm.nih.gov]

The child had short lower arms with small hands and clinodactyly of the fifth finger. [endocrine-abstracts.org]

Crossed Polysyndactyly

Additional appendicular skeletal anomalies also in- clude tapered fingers and fifth finger clinodactyly. [documentslide.com]

(Has X-Rays) Clinodactyly and Camptodactyly Ectrodactyly Ectrodactyly Cardiopathy Dysmorphism (Van den Ende Brunner Syndrome) Ectrodactyly Dominant Form (deletion 7q2, split [catsclem.nl]

The grey digital elements show hypoplastic phalanges or clinodactyly/brachydactyly. [nature.com]

Mohr Syndrome

[mor] Etymology: Otto Lous Mohr, Norwegian geneticist, 1886-1967 an autosomal recessive disorder characterized by brachydactyly, clinodactyly, polydactyly, syndactyly, and [medical-dictionary.thefreedictionary.com]

Both hands have clinodactyly and preaxial polydactyly as there are 7 fingers (duplicate thumb). There is also syndactyly between thumbs (bifid thumb) in each hand. [aclr.com.es]

Furthermore, the digital abnormalities include pre- and post-axial polydactyly of the hands and feet, partial bilateral duplication of the hallux, syndactyly, clinodactyly [symptoma.com]

Distal Symphalangism

Etiology and Epidemiology Clinodactyly Clinodactyly by definition is 10 degrees of digital deviation in the radioulnar plane. [musculoskeletalkey.com]

[…] of the 5th finger Syndactyly Clinodactyly SOURCES: GARD SCTID MONDO MESH UMLS OMIM ORPHANET More info about SYNDACTYLY, MESOAXIAL SYNOSTOTIC, WITH PHALANGEAL REDUCTION; MSSD [mendelian.co]

Clinodactyly deformity in radio-ulnar plane, Rx rarely indicated, stretching/splinting ineffective. Camptodactyly deformity in A/P plane. [eorif.com]

Spondylocarpotarsal Synostosis

Cleft palate, sensorineural or mixed hearing loss, joint limitation, clinodactyly, and dental enamel hypoplasia are variable manifestations. [ncbi.nlm.nih.gov]

Block vertebrae ; Bowed humerus ; Brachydactyly ; Broad face ; Broad nasal tip ; C2-C3 subluxation ; Capitate-hamate fusion ; Carpal synostosis ; Cataract ; Cleft palate ; Clinodactyly [mousephenotype.org]

Saethre-Chotzen Syndrome

52 cm, facial asymmetry, low hairline, proptosis, antimongoloid slanting of palpebral fissures, nasal deviation with high bridge, angled ears, scoliosis and torticollis, clinodactyly [ncbi.nlm.nih.gov]

[…] syndrome include unilateral or bilateral coronal synostosis, ptosis, low-set ears, hearing loss, hypertelorism, maxillary hypoplasia, deviated nasal septum, broad great toes, clinodactyly [ncbi.nlm.nih.gov]

[…] a third of our patients with TWIST mutations, are coronal synostosis, brachycephaly, low frontal hairline, facial asymmetry, ptosis, hypertelorism, broad great toes, and clinodactyly [ncbi.nlm.nih.gov]

Short Stature due to Endocrine Disorder

[…] include variable degrees of intellectual deficit, microcephaly and dysmorphism (broad nasal bridge and tip, smooth philtrum, thin upper and everted lower lips, short fingers, clinodactyly [orpha.net]

[…] is not available through HPO Abnormality of metabolism/homeostasis Laboratory abnormality Metabolism abnormality [ more ] 0001939 Autosomal recessive inheritance 0000007 Clinodactyly [rarediseases.info.nih.gov]

[…] nasal tip Increased breadth of tip of nose Increased width of nasal tip Increased width of tip of nose Nasal tip, broad Nasal tip, wide Wide tip of nose [ more ] 0000455 Clinodactyly [rarediseases.info.nih.gov]

Acrocephalopolysyndactyly

[…] related to Acrocephalopolysyndactyly Type Iv: Human phenotypes related to Acrocephalopolysyndactyly Type Iv: 33 (show all 8) # Description HPO Frequency HPO Source Accession 1 clinodactyly [malacards.org]

[…] spina bifida occulta scoliosis coxa valga decreased hip-joint mobility flared ilia genu valgum lateral displacement of patellae brachydactyly hand postaxial polydactyly clinodactyly [humpath.com]

Acrocephalopolysyndactyly Type Iv Synonyms ACPS IV, GOODMAN SYNDROME Classification bone, developmental, genetic Phenotypes Autosomal recessive inheritance ; Camptodactyly ; Clinodactyly [mousephenotype.org]