Clitoral Hypoplasia: Causes & Reasons

Possible Causes for Clitoral Hypoplasia

hypoplasia Small clitoris Underdeveloped clit [ more ] 0000060 Cutaneous photosensitivity Photosensitive skin Photosensitive skin rashes Photosensitivity Sensitivity to sunlight [rarediseases.info.nih.gov]

(eg, cryptorchidism, scrotal hypoplasia, clitoral hypoplasia). [37] Neonatal hypotonia is one of the hallmark features of this disorder and is a valuable clue to initiate [emedicine.medscape.com]

PWS females are born with hypoplasia of the external genitalia with labia minora and clitoral hypoplasia in up to 76% (24). [tp.amegroups.com]

Autosomal-Recessive Robinow Syndrome

[…] involving the metacarpal bones ; Autosomal recessive inheritance ; Bifid distal phalanx of toe ; Bifid tongue ; Brachydactyly ; Broad thumb ; Broad toe ; Clinodactyly ; Clitoral [mousephenotype.org]

Sacral dimple (HP:0000960), Clitoral hypoplasia (HP:0000060), Vesicoureteral reflux (HP_0000076), Omphalocele (HP_0001539) - - Familial, autosomal dominant 10y - - - - Pieter [databases.lovd.nl]

hypoplasia Small clitoris Underdeveloped clit [ more ] 0000060 Cryptorchidism Undescended testes Undescended testis [ more ] 0000028 Delayed cranial suture closure 0000270 [rarediseases.info.nih.gov]

Partial Monosomy 11q

Microcornea Microphthalmia Optic atrophy Ptosis Strabismus Abnormality of the genitourinary system Clitoral hypoplasia Cryptorchidism Hypospadias Labial hypoplasia Abnormality [ncbi.nlm.nih.gov]

[…] defect Abnormality of the digestive system Annular pancreas Pyloric stenosis Abnormality of the eye Amblyopia Chorioretinal coloboma Hypertelorism Iris coloboma Macular hypoplasia [ncbi.nlm.nih.gov]

RAB18 Deficiency

Hypogonadism – when present – manifests in both syndromes, in males as micropenis and/or cryptorchidism and in females as hypoplastic labia minora, clitoral hypoplasia, and [pubmed.ncbi.nlm.nih.gov]

Chromosome 4q32.1-q32.2 Triplication Syndrome

hypoplasia Normocytic anemia Fingernail dysplasia Abnormality of metabolism/homeostasis Intellectual disability, mild Polyhydramnios Narrow chest Knee osteoarthritis Flattened [mendelian.co]

[…] short stature Exaggerated cupid's bow Broad toe Ankyloglossia Forearm undergrowth Abnormal tricuspid valve morphology Triangular mouth Delayed eruption of permanent teeth Clitoral [mendelian.co]

Warburg Micro Syndrome 3

Hypogonadism – when present – manifests in both syndromes, in males as micropenis and/or cryptorchidism and in females as hypoplastic labia minora, clitoral hypoplasia, and [ncbi.nlm.nih.gov]

hypoplasia. [bio2rdf.org]

[…] retardation with no words or signs, axial hypotonia, hypotonic upper limbs, hypertonic lower limbs with contractures, myoclonic seizures, and hypoplastic labia minora and clitoral [bio2rdf.org]

Isolated Congenital Breast Hypoplasia or Aplasia

[…] displaced anus, intestinal malrotation, esophageal papillomas, inguinal hernia, clitoral hypoplasia, labial hypoplasia, cryptorchidism, horseshoe kidney, hydronephrosis, [iofbonehealth.org]

rib hypoplasia, supernumerary nipples, symmetric breast, nipple hypoplasia, diaphragmatic hernia, umbilical hernia, omphalocele, diastasis recti, hiatus hernia, anteriorly [iofbonehealth.org]

[…] cleft lip, cleft palate, hypodontia, oligodontia, enamel hypoplasia, delayed eruption, malocclusion, notched incisors, papillomatosis, midclavicular aplasia, midclavicular hypoplasia [iofbonehealth.org]

Meier-Gorlin Syndrome

[…] hypertrophy ; Clitoral hypoplasia ; Craniosynostosis ; Cryptorchidism ; Delayed skeletal maturation ; Elbow dislocation ; Epispadias ; Failure to thrive ; Feeding difficulties [mousephenotype.org]

[…] the ribs ; Anotia ; Aplastic clavicle ; Atresia of the external auditory canal ; Bifid uvula ; Breast aplasia ; Camptodactyly of finger ; Clinodactyly of the 5th finger ; Clitoral [mousephenotype.org]

Ankyloblepharon Filiforme Adnatum - Imperforate Anus

OMIM:613159 Peters-Plus Syndrome Cleft palate, Clitoral hypoplasia, Anteriorly placed anus, Umbilical hernia, Hypoplastic labia ma... [mousephenotype.org]

OMIM:270400 Renal Dysplasia-Limb Defects Syndrome High palate, Narrow mouth, Thin vermilion border, Neonatal death, Renal hypoplasia, Clitoral hype... [mousephenotype.org]

[…] of the uterus, Clitoral hypertrophy, Gonadal dysgenesis OMIM:612964 Normosmic Congenital Hypogonadotropic Hypogonadism Hypoplasia of the uterus, Hypoplasia of the ovary, [mousephenotype.org]

Complete Androgen Insensitivity Syndrome

Hospital case notes review, and genital examination for prevalence of vaginal and clitoral hypoplasia. [citeseerx.ist.psu.edu]

Self-completed survey of sexual function, genital normality perceptions, and compliance and satisfaction with vaginal hypoplasia treatments. [ncbi.nlm.nih.gov]

Intervention(s): Self-completed survey of sexual function, genital normality perceptions, and compliance and satisfaction with vaginal hypoplasia treatments. [citeseerx.ist.psu.edu]

Hay-Wells Syndrome

[…] nodules, hypoplastic external genitalia with clitoral hypertrophy, hypoplasia of the nails, a tendency towards dorsiflexion of the big toe on both feet, ankyloblepharon filiforme [ncbi.nlm.nih.gov]

The neonatal report outlines dysplastic phenotype, micrognathia, hypoplasia of the hard and soft palate, cleft palate, small nose, mammary hypoplasia with ectopic mammary [ncbi.nlm.nih.gov]

Myelocerebellar Disorder

hypoplasia Poor gross motor coordination Almond-shaped palpebral fissure Hypoplastic labia minora Narrow palm Temperature instability Central adrenal insufficiency Disseminated [mendelian.co]

Hypogonadotrophic hypogonadism Bradycardia Insulin resistance Cyanosis Clumsiness Abnormality of the cardiovascular system Striae distensae Central hypotonia Primary amenorrhea Clitoral [mendelian.co]

Retinitis Pigmentosa 9

[…] of the vagina, Cryptorchidism, Clitoral hypoplasia, Hypoplas... [mousephenotype.org]

[…] ovarian insufficiency, Gonadal dysgenesis, Clitoral hypertrophy OMIM:612964 46,Xy Sex Reversal 7 Abnormality of the epididymis, Hypoplasia of the uterus, Gonadal dysgenesis [mousephenotype.org]

OMIM:261540 Peters Plus Syndrome Cryptorchidism, Clitoral hypoplasia, Hypoplasia of the uterus, Hypospadias ORPHA:709 Pallister-Killian Syndrome Hypoplastic labia majora, [mousephenotype.org]

Brachyphalangy Polydactyly and Tibial Aplasia/Hypoplasia

Clitoral hypoplasia MedGen UID: 336198 • Concept ID: C1844527 • Finding Developmental hypoplasia of the clitoris. [ncbi.nlm.nih.gov]

Patellar hypoplasia MedGen UID: 327021 • Concept ID: C1840068 • Finding Underdevelopment of the patella. [ncbi.nlm.nih.gov]

Robinow Syndrome

Other common features include micropenis with or without cryptorchidism in males and reduced clitoral size and hypoplasia of the labia majora in females, renal tract abnormalities [ncbi.nlm.nih.gov]

Genital abnormalities in affected females are generally subtle, most commonly with reduced clitoral size and hypoplasia of the labia minora, although more rare anomalies such [hindawi.com]

Pelviscapular Dysplasia

hypoplasia Bilobate gallbladder Intestinal fistula Anterior chamber synechiae Square pelvis bone Agenesis of maxillary lateral incisor Facial hypertrichosis Conical incisor [mendelian.co]

[…] ears Wide mouth Thin upper lip vermilion Umbilical hernia Cerebral cortical atrophy Pes cavus Hypospadias Multicystic kidney dysplasia Short metatarsal Cerebral atrophy Clitoral [mendelian.co]

Lethal Occipital Encephalocele - Skeletal Dysplasia Syndrome

hypoplasia Narrow palm Abdominal obesity Anteverted ears Frontal upsweep of hair Cor pulmonale Generalized hypopigmentation Left ventricular hypertrophy Labial hypoplasia [mendelian.co]

[…] coordination Temperature instability Central adrenal insufficiency Disseminated intravascular coagulation Psychotic episodes Triangular mouth Short proximal phalanx of thumb Clitoral [mendelian.co]

Hypomandibular Faciocranial Dysostosis

hypoplasia Reticular hyperpigmentation Mania Abnormal adipose tissue morphology Absent speech Abnormality of the kidney Autistic behavior Genu valgum Irritability Developmental [mendelian.co]

Low anterior hairline Generalized hirsutism Short thorax Sclerocornea Underdeveloped supraorbital ridges Abnormal eyelid morphology Wide anterior fontanel Clitoral hypertrophy [mendelian.co]

[…] return Inspiratory stridor Foot oligodactyly Abnormal cornea morphology Patchy alopecia Cholangitis Abnormality of the middle ear Total anomalous pulmonary venous return Clitoral [mendelian.co]

Komuragaeri Disease

hypoplasia Breast hypoplasia Oligospermia Low hanging columella Hypoplastic pelvis Agenesis of permanent teeth Gingival overgrowth High pitched voice Cone-shaped epiphysis [mendelian.co]

[…] retardation Wide mouth Osteopenia Mandibular prognathia Oxycephaly Type II diabetes mellitus Dental crowding Retrognathia Hypoplastic fingernail Hypoplastic sacrum Frontal balding Clitoral [mendelian.co]

Warburg-Sjo-Fledelius Syndrome

hypoplasia Clitoral hypoplasia phenotype Finding 30 0.100 0 CUI: C1842366 Disease: Low anterior hairline Low anterior hairline phenotype Finding 48 1 0.100 0 CUI: C4280808 [disgenet.org]

[…] phenotype Acquired Abnormality 156 0.100 0 CUI: C4280625 Disease: Decreased size of eyeball Decreased size of eyeball phenotype Finding 144 0.100 0 CUI: C1844527 Disease: Clitoral [disgenet.org]

Ehlers-Danlos Syndrome Type Beasley-Cohen

hypoplasia Abdominal distention Hypoplastic toenails Septo-optic dysplasia Narrow nasal bridge Disseminated intravascular coagulation Short toe Atrial septal defect Hypothermia [mendelian.co]

Erysipelas Narrow palm Poor fine motor coordination Hypoplastic labia minora Almond-shaped palpebral fissure Poor gross motor coordination Acromicria Fatigue Constipation Clitoral [mendelian.co]

Unilateral Hypoplasia or Absence of Pectoralis Major Muscle

[…] scalp veins Advanced ossification of carpal bones Forearm undergrowth Respiratory tract infection Hip dislocation Long toe Hypoplastic nipples Diaphragmatic eventration Clitoral [mendelian.co]

hypoplasia Long clavicles Fused cervical vertebrae Rib fusion Male hypogonadism Patellar aplasia Furrowed tongue Abnormality of the neck Down-sloping shoulders Distal arthrogryposis [mendelian.co]

Microcornea

Hypogonadism – when present – manifests in both syndromes, in males as micropenis and/or cryptorchidism and in females as hypoplastic labia minora, clitoral hypoplasia, and [ncbi.nlm.nih.gov]

[…] involving the skeletal musculature Joint stiffness Retinal atrophy Abnormal aldolase level Clitoral hypoplasia Fine hair Corneal opacity Dysphonia Brittle hair Osteoporosis [mendelian.co]

[…] dysplasia Long philtrum Elevated serum creatine phosphokinase Severe global developmental delay Congenital muscular dystrophy Coloboma Low-set, posteriorly rotated ears Aplasia/Hypoplasia [mendelian.co]

Adactyly of Foot

[…] of the vagina Exaggerated cupid's bow Birth length less than 3rd percentile Rieger anomaly Clitoral hypoplasia Abnormality of the pulmonary artery Mandibular prognathia Hypothyroidism [mendelian.co]

[…] gallbladder Anterior chamber synechiae Hypogonadism Square pelvis bone Agenesis of maxillary lateral incisor Facial hypertrichosis Conical incisor Short lingual frenulum Hypoplasia [mendelian.co]

Pfeiffer-Palm-Teller Syndrome

hypoplasia Diabetes mellitus Labial hypoplasia Abnormality of lipid metabolism Hypogonadism Stroke Carious teeth Hypoglycemia Tracheomalacia Anal stenosis Failure to thrive [mendelian.co]

Hypogonadotrophic hypogonadism Obesity Diastasis recti Motor delay Neoplasm Glucose intolerance Kyphosis Congestive heart failure Hydrocephalus Syndactyly Tracheoesophageal fistula Clitoral [mendelian.co]

Humero-Radial Synostosis

hypoplasia Abnormality of dental enamel Preauricular skin tag Pancytopenia Fine hair Chronic diarrhea Hepatic fibrosis Aortic regurgitation Short ear Leukopenia Woolly hair [mendelian.co]

Postnatal growth retardation Intellectual disability, severe Ptosis Wide nose Sepsis Hepatic failure Premature birth Aciduria Tetralogy of Fallot Absent sternal ossification Clitoral [mendelian.co]

Jacobsen Syndrome

hypoplasia Small clitoris Underdeveloped clit [ more ] 0000060 Depressed nasal bridge Depressed bridge of nose Flat bridge of nose Flat nasal bridge Flat, nasal bridge Flattened [rarediseases.info.nih.gov]

[…] coloboma Birth defect that causes a hole in the innermost layer at the back of the eye 0000567 Clinodactyly of the 5th finger Permanent curving of the pinkie finger 0004209 Clitoral [rarediseases.info.nih.gov]

Familial Congenital Nasolacrimal Duct Obstruction

Clitoral hypoplasia; [Internal genitalia, male]; Cryptorchidism SKELETAL: [Limbs]; Joint contractures; [Hands]; Fifth finger clinodactyly; Brachydactyly NEUROLOGIC: [Central [genome.jp]

ABDOMEN: [Pancreas]; Annular pancreas; [Gastrointestinal]; Pyloric stenosis GENITOURINARY: [External genitalia, male]; Hypospadias; [External genitalia, female]; Labial hypoplasia [genome.jp]

Stevenson Carey Syndrome

hypoplasia Strabismus Hypoplastic labia minora Brachycephaly Arrhythmia Congenital onset Optic atrophy Short philtrum Flat face Pain Depressed nasal bridge Contractures of [mendelian.co]

Small for gestational age Long palpebral fissure Clinodactyly of the 5th finger Elbow flexion contracture Postnatal growth retardation Hypsarrhythmia High, narrow palate Clitoral [mendelian.co]

X-Linked Lethal Multiple Pterygium Syndrome

hypoplasia Male hypogonadism Flushing Popliteal pterygium Hypoplasia of the musculature Oculomotor nerve palsy Prune belly Laryngeal stenosis Aplasia of the pectoralis major [mendelian.co]

[…] phalanx of finger Megalocornea Narrow palpebral fissure Finger clinodactyly Abnormality of the hand Short toe Nephritis Abnormality of the larynx Ulnar deviation of the hand Clitoral [mendelian.co]