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374 Possible Causes for Clonus, Hyperreflexia, Muscle Hypotonia

  • Myelopathy

    Physical examination revealed significant increase in deep tendon reflexes in the lower extremities and clonus. Hoffman's sign was positive in the left upper extremity.[ncbi.nlm.nih.gov] Clinical hyperreflexia was tested at the MCP joint, using a six-axis load cell.[ncbi.nlm.nih.gov] […] with radicular symptoms - 16% had pure myelopathic symptoms - 23% had a combination of myelopathic and radiculopathy - upper motor neuron findings such as hyper-reflexia, clonus[wheelessonline.com]

  • Infantile-Onset Autosomal Recessive Nonprogressive Cerebellar Ataxia

    Decreased muscle tone Low muscle tone [ more ] 0001290 Hyperreflexia Increased reflexes 0001347 Intention tremor 0002080 Motor delay 0001270 Muscular hypotonia Low or weak[rarediseases.info.nih.gov] […] reduction of nerve transmission giving rise to various clinical manifestations such as paresthesias, loss of vibratory sensation, and proprioception.Severe weakness, spasticity, clonus[explainmedicine.com] IAHSP is characterized by onset of spasticity with increased reflexes and sustained clonus of the lower limbs within the first two years of life, progressive weakness and[cmm.ucsd.edu]

  • Tay-Sachs Disease

    […] attentiveness Increased startle response A cherry red spot of the fovea centralis of the macula of the retina can be seen in 90% of cases Hyperreflexia with sustained ankle clonus[en.wikibooks.org] Examination of reflexes shows hyperreflexia.[patient.info] At 6 to 10 months limp and floppy muscles (hypotonia). decreased alertness and playfulness. difficulty sitting up or rolling over loss of motor skills. decreased hearing and[radiopaedia.org]

  • Spastic Paraplegia

    This case showed spasticity and hyperreflexia with pathological reflexes and ankle clonus as well as muscle weakness in all extremities.[ncbi.nlm.nih.gov] In infancy, children with SPG47 have very low muscle tone ( hypotonia ).[childrenshospital.org] The knee-jerk is excessive and ankle-clonus is easily obtained.[henriettes-herb.com]

  • Primary Progressive Multiple Sclerosis

    Affected individuals may have tremors, muscle stiffness (spasticity), exaggerated reflexes (hyperreflexia), weakness or partial paralysis of the muscles of the limbs, difficulty[icdlist.com] : Loss of muscle tone Gait ataxia: Loss of balance Dysmetria : Inability to coordinate movement in which your either overshoot or undershoot the intended position of your[verywell.com] […] cerebellar syndrome (PCS), is seen less often than progressive myelopathy but can manifest with: Tremor: Impairment of fine hand movement due to severe intention tremor Hypotonia[verywell.com]

  • Congenital Muscular Dystrophy

    Congenital muscular dystrophy (CMD) comprises a heterogeneous group of disorders with muscle weakness, hypotonia and contractures present at birth.[ncbi.nlm.nih.gov] Calf pseudohypertrophy may resemble that seen in Duchenne muscular dystrophy CNS malformation and abnormal white matter: may be evident as: Pyramidal signs (hyperreflexia, clonus[ncbi.nlm.nih.gov] Paradoxically, some patients have limb spasticity and hyperreflexia with pyramidal signs. No cerebellar signs are present.[disorders.eyes.arizona.edu]

  • Muscle Spasticity

    The presence of clonus can be a sign of neurologic problems but alone is not enough for diagnostic purposes.[pediatricservices.com] Spasticity is usually accompanied by HYPERREFLEXIA and variable degrees of MUSCLE WEAKNESS.[profiles.umassmed.edu] Hypotonia – is lower than normal tone, creating muscles that are “floppy”.[uclaccp.org]

  • Cerebral Palsy with Spastic Diplegia

    During testing we observed clonus only in gastrocnemius and soleus muscles.[omicsonline.org] Classification Physiologic Classification Spastic (most common) Velocity-dependent increased muscle tone and hyperreflexia with slow, restricted movement due to simultaneous[orthobullets.com] Hypotonia – Decreased muscle tone from expected (See muscle tone).[childneurologyfoundation.org]

  • Mitochondrial Complex 3 Deficiency

    […] syndrome Progressive leukoencephalopathy Fatigable weakness of swallowing muscles Diffuse hepatic steatosis Poor suck Hepatic failure Rigidity Drooling Aggressive behavior Clonus[mendelian.co] Encephalopathy can cause delayed development of mental and motor skills (psychomotor delay), movement problems, weak muscle tone (hypotonia), and difficulty with communication[ghr.nlm.nih.gov] SUCLA2 patients present with psychomotor retardation, muscle hypotonia, hearing impairment and seizures [ 89 ], whereas those with SUCLG1 mutations have encephalomyopathy[em-consulte.com]

  • Spinocerebellar Ataxia Type 13

    Tendon reflex is active, ankle clonus is positive. Double side pathological sign is positive. Left body pain is decline. Deep feeling is existed.[oatext.com] : Clinical features Age of onset - 43-56 years Slow progression Gait and limb ataxia Dysarthria Occular dysmetria Slow saccades Decreased vibratory sense below the knees Hyperreflexia[emedicine.com] hypotonia.[cerebellumandataxias.biomedcentral.com]

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