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334 Possible Causes for Clonus, Hyperreflexia, Muscle Hypotonia

  • Myelopathy

    […] with radicular symptoms - 16% had pure myelopathic symptoms - 23% had a combination of myelopathic and radiculopathy - upper motor neuron findings such as hyper-reflexia, clonus[] Clinical hyperreflexia was tested at the MCP joint, using a six-axis load cell.[] Motor weakness in the extremities Gait difficulties ("spastic gait," hesitant and jerky) Myelopathic or "upper motor neuron" findings such as spasticity, hyperreflexia, clonus[]

  • Tay-Sachs Disease

    […] attentiveness Increased startle response A cherry red spot of the fovea centralis of the macula of the retina can be seen in 90% of cases Hyperreflexia with sustained ankle clonus[] Examination of reflexes shows hyperreflexia.[] At 6 to 10 months limp and floppy muscles (hypotonia). decreased alertness and playfulness. difficulty sitting up or rolling over loss of motor skills. decreased hearing and[]

  • Maple Syrup Urine Disease

    […] rigidity) and hypotonia (muscle limpness) high-pitched cry Signs of intermediate and thiamine-response MSUD include: seizures neurological deficiencies developmental delays[] Cerebral edema: If neurological signs develop or worsen (vomiting, lethargy, hyperreflexia, clonus), suspect cerebral edema.[] Signs and symptoms of Maple Syrup Urine Disease are: Poor feeding, lack of energy (lethargy) Vomiting Poor muscle tone (hypotonia) Developmental delay Backward arching of[]

  • Pelizaeus-Merzbacher Disease

    No hyperreflexia or clonus were present at that moment. No other abnormalities including dysmorphic features were noticed.[] Last neurological examination in 1999 showed no nystagmus anymore, but extremely dystrophic limbs, truncal deformation, due to severe scoliosis, tetraplegia with hyperreflexia[] The difficulties with movement can include spasticity (stiff or rigid muscles), hypotonia (floppiness), choreoathetosis (extra movements) and ataxia (unsteadiness/loss of[]

  • Niemann-Pick Disease Type C

    Neurological examination revealed a broad-based ataxic gait, limb dysmetria, downward vertical gaze palsy, brisk lower limb reflexes and ankle clonus, while neuropsychological[] […] examination, including psychomotor slowing, memory difficulties, and impairment of higher attentional functions; physical findings of subtle downgaze impairment, mild symmetrical hyperreflexia[] In other cases, additional symptoms develop including lack of muscle tone (hypotonia) often by 1 or 2 years of age.[]

  • Lesch Nyhan Syndrome

    […] tone or soft muscles (hypotonia).[] Many also show pyramidal features, including hyperreflexia and ankle clonus. Delay in walking is noted and eventually all patients require a wheelchair.[] It is typically characterized by choreoathetosis, hypertonia, hyperreflexia, and self-mutilation.[]

  • Neonatal Adrenoleukodystrophy

    Deep tendon reflexes were brisk with anide clonus and bilateral extensor plantars. Pupils were round arid reacting to light. Fundoscopic examination was normal.[] Hypotonia is replaced by hypertonia with hyperreflexia. Epilepsy may become more severe and sensorineural hearing loss may appear.[] Abnormal clinical features in neonatal adrenoleukodystrophy are generally present at birth, and include muscle hypotonia, severe psychomotor retardation, and failure to thrive[]

  • Spastic Paraplegia

    In infancy, children with SPG47 have very low muscle tone ( hypotonia ).[] The knee-jerk is excessive and ankle-clonus is easily obtained.[] On neurological examination, he showed hyperreflexia, spasticity, and weakness in the lower extremities and bilateral Babinski reflexes.[]

  • Zellweger Syndrome

    At 4 years of age, she developed nystagmus, hyperreflexia, clonus, and extensor plantar responses.[] The mitochondrial myopathy thereby induced allows a better understanding of general muscle hypotonia, one of the leading symptoms of this disorder.[] Zellweger syndrome is typically seen in the neonatal period with features such as dysmorphic skull; muscle hypotonia; sensorineural hearing loss; visual compromise; seizures[]

  • Spinocerebellar Ataxia Type 13

    Tendon reflex is active, ankle clonus is positive. Double side pathological sign is positive. Left body pain is decline. Deep feeling is existed.[] Affected individuals show mild to profound mental retardation with poor or absent speech as well as gait and stance ataxia and hyperreflexia.[] hypotonia.[]

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