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225 Possible Causes for Clubbing of Nails, Splenomegaly

  • Subacute Bacterial Endocarditis

    Fever, anaemia, splenomegaly and positive blood cultures for Gram-negative bacteria were found on admission.[] The nail moves more freely in patients with clubbing; therefore, the examiner may note a spongy sensation as the nail is pressed toward the nail plate.[] Findings compatible with both SBE and marantic endocarditis due to a B-cell lymphoproliferative disorder included an elevated ESR, and splenomegaly.[]

  • Polycythemia Vera

    […] symptoms in the phase 3 RESPONSE study of patients with polycythemia vera with splenomegaly who experienced an inadequate response to or adverse effects from hydroxyurea.[] Signs of long standing hypoxia may include cyanosis (blue or purple appearing finger, nail, earlobes, or lips), clubbing of the fingers (elevation of the nail beds outward[] […] efficacy and safety of ruxolitinib with the best available therapy (BAT) in hydroxyurea-resistant/hydroxyurea-intolerant polycythemia vera (PV) patients without palpable splenomegaly[]

  • Erythropoietic Porphyria

    The consequences of chronic haemolysis are splenomegaly, reactive erythroid hyperplasia, erythrodontia, bone fragility, extreme photosensitivity and photomutilation.[] .  Nails – brittle, malformed, showed clubbing 15.[] Splenomegaly and hemolytic anemia are typical internal symptoms. Skeletal changes such as osteolysis and calcifications are frequent.[]

  • Portal Cirrhosis

    Liver cirrhosis: Liver cirrhosis with an inhomogeneous liver with irregular contour and ascites and splenomegaly Liver cirrhosis: Liver cirrhosis with an irregular liver contour[] Clubbing of the nails Palmar erythema – redness on the thenar and hypothenar eminences Spider naevi – swollen blood vessels under the skin radiating like a spiders web Telangiectasia[] […] with ground glass opacity Clubbed nails Hormone disorders Hyperestrogenism Changes in the hepatic metabolization of sex hormones causes an imbalance in the estrogen‑androgen[]

  • Castleman Disease

    Older age ( 40 years), splenomegaly, and hypoalbuminemia were risk factors for poorer MCD prognosis. 2017 The Authors.[] Other skin changes, including whitening of the proximal nails (Terry nails), peripheral edema, hyperhidrosis, clubbing of the fingers, Raynaud's phenomenon, and angiomas can[] Facing a patient with fever, peripheral lymphadenopathy, splenomegaly, and the biochemical and immunological picture depicted above, the physician may find it difficult to[]

  • Liver Cirrhosis

    We performed LS in 83 patients with massive splenomegaly ( 30 cm) secondary to portal hypertension and liver cirrhosis.[] (only in biliary cirrhosis) Terry’s “half & half” nails Duputryen's contracture ( Credit ) Petechiae and echymosis Scratch marks Edema Testicular atrophy (and how do you[] Terry's nails (double nails) – proximal two-thirds of the nail plate appears white with distal one-third red, also due to hypoalbuminemia Clubbing – angle between the nail[]

  • Pediatric Chronic Granulomatous Disease

    DANGER SIGNS: failure to thrive, inflammatory anemia, thrombocytopenia, splenomegaly, lymphadenopathy, joint swelling/bone pain, dysmorphia, recurrent serious infections,[] Clubbing of the nails of the hands and feet was present; the joints were normal. Figure 1 Vesicular lesions on the trunk, around a central crustous area.[] Anatomic:- dilatatie venoasa, - splenomegalie ( hipersplenisM), - transudatie peritoneala (ascitA), - formarea anastomozelor porto-cave: . gastro-esofagiene - fluxul portal[]

  • Pancreatic Insufficiency - Anemia - Hyperostosis Syndrome

    Splenomegaly MedGen UID: 52469 • Concept ID: C0038002 • Finding Abnormal enlargement of the spleen.[] […] of nail 4374004 TV - Congenital tricuspid valve abnormality 4381006 Verbal paraphasia 4386001 Bronchospasm 4390004 Chronic lithium nephrotoxicity 4397001 Partial congenital[] […] phenotypes associated to Hepatomegaly and Abnormality of the dentition Symptoms // Phenotype % cases Autosomal recessive inheritance Common - Between 50% and 80% cases Splenomegaly[]

  • Endocarditis

    PATIENT CONCERNS: A young woman, with a history of aortic stenosis, was admitted to our unit for a month of intermittent fever associated with a new diastolic heart murmur and splenomegaly[] With prolonged infection, clubbing of the fingers may also occur.[] Signs and symptoms include fever, chills, sweating, malaise, weakness, anorexia, weight loss, splenomegaly, flu-like feeling, cardiac murmur, heart failure, petechia (red[]

  • Alcoholic Liver Disease

    Splenomegaly : Portal hypertension causes the spleen to enlarge (a condition called splenomegaly).[] […] in your abdomen caused by a build-up of fluid known as ascites a high temperature (fever) and shivering attacks very itchy skin hair loss unusually curved fingertips and nails[] […] steatosis (fatty liver) From the collection of Dr McClain; used with permission History & Exam Key Factors abdominal pain hepatomegaly hematemesis and melena venous collaterals splenomegaly[]

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