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225 Possible Causes for Clubbing of Nails, Splenomegaly

  • Subacute Bacterial Endocarditis

    Fever, anaemia, splenomegaly and positive blood cultures for Gram-negative bacteria were found on admission.[ncbi.nlm.nih.gov] The nail moves more freely in patients with clubbing; therefore, the examiner may note a spongy sensation as the nail is pressed toward the nail plate.[emedicine.medscape.com] Findings compatible with both SBE and marantic endocarditis due to a B-cell lymphoproliferative disorder included an elevated ESR, and splenomegaly.[ncbi.nlm.nih.gov]

  • Polycythemia Vera

    […] symptoms in the phase 3 RESPONSE study of patients with polycythemia vera with splenomegaly who experienced an inadequate response to or adverse effects from hydroxyurea.[ncbi.nlm.nih.gov] Signs of long standing hypoxia may include cyanosis (blue or purple appearing finger, nail, earlobes, or lips), clubbing of the fingers (elevation of the nail beds outward[medicinenet.com] […] efficacy and safety of ruxolitinib with the best available therapy (BAT) in hydroxyurea-resistant/hydroxyurea-intolerant polycythemia vera (PV) patients without palpable splenomegaly[ncbi.nlm.nih.gov]

  • Erythropoietic Porphyria

    The consequences of chronic haemolysis are splenomegaly, reactive erythroid hyperplasia, erythrodontia, bone fragility, extreme photosensitivity and photomutilation.[ncbi.nlm.nih.gov] .  Nails – brittle, malformed, showed clubbing 15.[slideshare.net] Splenomegaly and hemolytic anemia are typical internal symptoms. Skeletal changes such as osteolysis and calcifications are frequent.[ncbi.nlm.nih.gov]

  • Portal Cirrhosis

    Liver cirrhosis: Liver cirrhosis with an inhomogeneous liver with irregular contour and ascites and splenomegaly Liver cirrhosis: Liver cirrhosis with an irregular liver contour[ultrasoundcases.info] Clubbing of the nails Palmar erythema – redness on the thenar and hypothenar eminences Spider naevi – swollen blood vessels under the skin radiating like a spiders web Telangiectasia[kenhub.com] […] with ground glass opacity Clubbed nails Hormone disorders Hyperestrogenism Changes in the hepatic metabolization of sex hormones causes an imbalance in the estrogen‑androgen[amboss.com]

  • Castleman Disease

    Older age ( 40 years), splenomegaly, and hypoalbuminemia were risk factors for poorer MCD prognosis. 2017 The Authors.[ncbi.nlm.nih.gov] Other skin changes, including whitening of the proximal nails (Terry nails), peripheral edema, hyperhidrosis, clubbing of the fingers, Raynaud's phenomenon, and angiomas can[clinicaladvisor.com] Facing a patient with fever, peripheral lymphadenopathy, splenomegaly, and the biochemical and immunological picture depicted above, the physician may find it difficult to[symptoma.com]

  • Liver Cirrhosis

    We performed LS in 83 patients with massive splenomegaly ( 30 cm) secondary to portal hypertension and liver cirrhosis.[ncbi.nlm.nih.gov] (only in biliary cirrhosis) Terry’s “half & half” nails Duputryen's contracture ( Credit ) Petechiae and echymosis Scratch marks Edema Testicular atrophy (and how do you[stanfordmedicine25.stanford.edu] Terry's nails (double nails) – proximal two-thirds of the nail plate appears white with distal one-third red, also due to hypoalbuminemia Clubbing – angle between the nail[en.wikipedia.org]

  • Pediatric Chronic Granulomatous Disease

    DANGER SIGNS: failure to thrive, inflammatory anemia, thrombocytopenia, splenomegaly, lymphadenopathy, joint swelling/bone pain, dysmorphia, recurrent serious infections,[hawaii.edu] Clubbing of the nails of the hands and feet was present; the joints were normal. Figure 1 Vesicular lesions on the trunk, around a central crustous area.[adc.bmj.com] Anatomic:- dilatatie venoasa, - splenomegalie ( hipersplenisM), - transudatie peritoneala (ascitA), - formarea anastomozelor porto-cave: . gastro-esofagiene - fluxul portal[mediculmeu.com]

  • Pancreatic Insufficiency - Anemia - Hyperostosis Syndrome

    Splenomegaly MedGen UID: 52469 • Concept ID: C0038002 • Finding Abnormal enlargement of the spleen.[ncbi.nlm.nih.gov] […] of nail 4374004 TV - Congenital tricuspid valve abnormality 4381006 Verbal paraphasia 4386001 Bronchospasm 4390004 Chronic lithium nephrotoxicity 4397001 Partial congenital[build.fhir.org] […] phenotypes associated to Hepatomegaly and Abnormality of the dentition Symptoms // Phenotype % cases Autosomal recessive inheritance Common - Between 50% and 80% cases Splenomegaly[mendelian.co]

  • Endocarditis

    PATIENT CONCERNS: A young woman, with a history of aortic stenosis, was admitted to our unit for a month of intermittent fever associated with a new diastolic heart murmur and splenomegaly[ncbi.nlm.nih.gov] With prolonged infection, clubbing of the fingers may also occur.[rarediseases.org] Signs and symptoms include fever, chills, sweating, malaise, weakness, anorexia, weight loss, splenomegaly, flu-like feeling, cardiac murmur, heart failure, petechia (red[en.wikipedia.org]

  • Alcoholic Liver Disease

    Splenomegaly : Portal hypertension causes the spleen to enlarge (a condition called splenomegaly).[msdmanuals.com] […] in your abdomen caused by a build-up of fluid known as ascites a high temperature (fever) and shivering attacks very itchy skin hair loss unusually curved fingertips and nails[nhs.uk] […] steatosis (fatty liver) From the collection of Dr McClain; used with permission History & Exam Key Factors abdominal pain hepatomegaly hematemesis and melena venous collaterals splenomegaly[online.epocrates.com]

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