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619 Possible Causes for Clumsiness, Enlargement of the Spleen

  • Niemann-Pick Disease Type C

    Ultrasound can detect the enlarged liver and spleen that's caused by type C.[mayoclinic.org] One of the twins presented with a history of obsessive-compulsive disorder and slowly progressive inferior limb clumsiness, dysphagia and dysarthria.[ncbi.nlm.nih.gov] In Case 1, a 25-year-old man presented with a 14-year history of intellectual disability, clumsiness, spastic ataxia, dysphagia, and frequent falls.[ncbi.nlm.nih.gov]

  • Niemann-Pick Disease

    Ultrasound can detect the enlarged liver and spleen that's caused by type C.[mayoclinic.org] Niemann-Pick care at Mayo Clinic Symptoms Niemann-Pick signs and symptoms may include: Clumsiness and difficulty walking Excessive muscle contractions (dystonia) or eye movements[mayoclinic.org] […] after) birth An enlarged spleen and/or liver (hepatosplenamegaly) Difficulty with upward and downward eye movements (Vertical Supranuclear Gaze Palsy) Unsteadiness of gait, clumsiness[npuk.org]

  • Mucopolysaccharidosis

    […] tongue), corneal clouding, hearing loss, heart problems, an enlarged liver and spleen, hernias, chronic nasal congestion and ear infections.[luriechildrens.org] […] children who have Hunter syndrome but may be underdiagnosed, for patients’ cognitive impairment often prevents them from accurately describing their symptoms. 17,25 Manual clumsiness[touchneurology.com] […] liver and spleen (hepatosplenomegaly), and a large tongue (macroglossia).[ghr.nlm.nih.gov]

  • Mucopolysaccharidosis 4

    Other features include intellectual disability, enlarged liver and spleen, stiffness of the joints, hearing loss and seizures. No treatment is known.[sema4genomics.com] […] children who have Hunter syndrome but may be underdiagnosed, for patients’ cognitive impairment often prevents them from accurately describing their symptoms. 17,25 Manual clumsiness[touchneurology.com] […] liver Enlarged spleen Limited energy Getting a diagnosis of Morquio A is an important first step toward getting treatment.[biomarin.com]

  • Niemann-Pick Disease Type B

    Typically by age six months of age the patient experiences an enlarged liver and spleen, vomitting, and difficulity in feeding.[niemann-pickdisease.com] […] irregular speech Sudden loss of muscle tone which may lead to falls (cataplexy) Tremors Trouble moving the eyes up and down (vertical supranuclear gaze palsy) Unsteady gait, clumsiness[medindia.net] Symptoms may include: Difficulty moving limbs that may lead to unsteady gait, clumsiness, walking problems Enlarged spleen Enlarged liver Jaundice at (or shortly after) birth[nlm.nih.gov]

  • Duchenne Muscular Dystrophy

    […] heterozygotes for severe defects are affected with thalassemia major or Cooley's anemia, lethal if untreated, and suffer pronounced anemia, bone deformities, and hepatomegaly and splenomegaly[doi.org] DMD typically appears between the ages of two with weakness in the pelvis and upper limbs, resulting in clumsiness, frequent falling, an unusual gait and general weakness.[medterms.com] Additional early signs and symptoms include: Developmental delay Muscle weakness Clumsiness Waddling gait Difficulty or inability to perform activities such as climbing stairs[pfizer.com]

  • Alpha-Mannosidosis

    Signs and symptoms of alpha-mannosidosis include intellectual disability, hearing loss, distinctive facial features, enlarged liver and spleen, immune dysfunction leading[secure.ssa.gov] Mental and motor development is delayed, but in this context, the progressive course of AM has to be considered: Affected children often appear clumsy, and milestones in speech[symptoma.com] Associated motor function disturbances The development of motor functions in affected patients is generally slow, and the children appear clumsy.[ojrd.com]

  • Early Infantile Epileptic Encephalopathy Type 6

    Splenomegaly is a frequently observed feature. Age of onset and severity vary considerably.[centogene.com] Under regular following up for ten years, the patient had normal expressive language and mild motor clumsiness.[ncbi.nlm.nih.gov] In addition to seizures, psychomotor development becomes affected from the second year of life, together with ataxia and clumsiness, while photosensitivity has been reported[symptoma.com]

  • Anemia

    […] of the spleen with certain causes of anemia Next: When to Seek Medical Care »[web.archive.org] […] fuzziness’ in thinking, nominal aphasia (forgetting the names of everyday objects), short-term memory loss and confusion (sometimes known as ‘handbag in the fridge syndrome’) Clumsiness[pernicious-anaemia-society.org] In 1995, Kinsella and Green described a 70-year-old man with paresthesias and hand clumsiness after 2 exposures to NO over 3 months.[web.archive.org]

  • Gaucher Disease

    […] platelets (thrombocytopenia), lung disease, and bone abnormalities such as bone pain, fractures, and arthritis [ghr.nlm.nih.gov] (hepatomegaly) and enlarged spleen (splenomegaly[symptoma.com] These children may also appear clumsy and off-balance because of their enlarged organs.[gaucherdisease.org.uk] People in this group usually bruise easily due to low blood platelets and experience fatigue due to anemia They also may have an enlarged liver and spleen.[ninds.nih.gov]

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