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792 Possible Causes for Clumsiness, Muscle Hypotonia

  • Duchenne Muscular Dystrophy

    , absent deep tendon reflexes and fasciculations 3 Mildly elevated creatine kinase levels, severe limb contractures present at an early age 4 Acute onset of weakness, hypotonia[] DMD typically appears between the ages of two with weakness in the pelvis and upper limbs, resulting in clumsiness, frequent falling, an unusual gait and general weakness.[] Additional early signs and symptoms include: Developmental delay Muscle weakness Clumsiness Waddling gait Difficulty or inability to perform activities such as climbing stairs[]

  • Niemann-Pick Disease Type C

    Decreased muscle tone Low muscle tone [4] A pulmonologist for respiratory problems A cardiologist for heart problems Liver and spleen specialists Nutritionists Physical therapists[] One of the twins presented with a history of obsessive-compulsive disorder and slowly progressive inferior limb clumsiness, dysphagia and dysarthria.[] In Case 1, a 25-year-old man presented with a 14-year history of intellectual disability, clumsiness, spastic ataxia, dysphagia, and frequent falls.[]

  • Alpha-Mannosidosis

    (hypotonia), and reduced sensation or other nervous system abnormalities in the extremities (peripheral neuropathy).[] Mental and motor development is delayed, but in this context, the progressive course of AM has to be considered: Affected children often appear clumsy, and milestones in speech[] Associated motor function disturbances The development of motor functions in affected patients is generally slow, and the children appear clumsy.[]

  • Myelopathy

    […] altered tonus, hyperreflexia and pathological reflexes, including Hoffmann's sign and inverted plantar reflex (positive Babinski sign) Lower motor neuron signs—weakness, clumsiness[] They include numb and clumsy hands, loss of coordination, and imbalance.[] When myelopathy, or spinal cord compression, creates problems, the symptoms and physical findings may include hand clumsiness, clumsiness of gait, numbness in the hands, jumpy[]

  • Aspartylglucosaminuria

    Additional musculoskeletal (thickening of the ribs and skull, lordosis, vertebral dysplasia, contractures in fingers and elbows, a knock knee, muscle atrophy and hypotonia[] The main indications for further studies were delayed speech, attention deficit and clumsy or delayed motor functions.[] Clinical description Clinical signs of AGU include slowly developping mental retardation, beginning with clumsiness, late speech, and hyperkinesia, mild facial dysmorphism[]

  • Motor Neuron Disease

    Loss of lower motor neurons causes denervation atrophy of muscle, manifested by severe hypotonia, weakness, and inability to breathe.[] Early symptoms may be noticed as weakness or clumsiness of the hand. Most people live for more than five years.[] Symptoms may include hypotonia (severely reduced muscle tone), diminished limb movements, lack of tendon reflexes, fasciculations, tremors, swallowing and feeding difficulties[]

  • Niemann-Pick Disease

    […] tone (hypotonia) Episodes of lactic acidosis (accumulation of lactic acid in the body and brain) that may impair breathing and kidney function Heart problems Diagnosis Diagnosis[] Niemann-Pick care at Mayo Clinic Symptoms Niemann-Pick signs and symptoms may include: Clumsiness and difficulty walking Excessive muscle contractions (dystonia) or eye movements[] […] after) birth An enlarged spleen and/or liver (hepatosplenamegaly) Difficulty with upward and downward eye movements (Vertical Supranuclear Gaze Palsy) Unsteadiness of gait, clumsiness[]

  • Autosomal Recessive Spinocerebellar Ataxia Type 17

    Hypotonia is a decrease in the normal resistance offered by muscles to passive manipulation When an affected limb is shaken flapping movements of the hands appear of wider[] Overview When people discuss spinal cerebellar ataxia (SCA), they are actually referring to a group of neurodegenerative disorders that cause progressive clumsiness.[] Autosomal recessive cerebellar ataxia must be considered in any child or young adult with a progressive disorder of gait or balance or with hypotonia or excessive clumsiness[]

  • Tay-Sachs Disease

    At 6 to 10 months limp and floppy muscles (hypotonia). decreased alertness and playfulness. difficulty sitting up or rolling over loss of motor skills. decreased hearing and[] The early signs are usually things like clumsiness and muscle weakness.[] At 6 to 10 months: •Limp and floppy muscles (hypotonia). •Decreased alertness and playfulness. •Difficulty sitting up or rolling over •Loss of motor skills.[]

  • Metachromatic Leukodystrophy

    The first symptom is usually an unsteady gait due to muscle hypotonia.[] In early-onset juvenile MLD, symptoms such as clumsiness and gait problems may be noticed first.[] Developmental delay Hypotonia: decreased muscle tone Esotropia: cross-eyed Psychomotor regression Clumsiness Spasticity: increased reflexes Nystagmus: type of abnormal eye[]

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