Create issue ticket

494 Possible Causes for Clumsiness, Splenomegaly

  • Niemann-Pick Disease Type C

    We report an unusual presentation of NPCD in a young asymptomatic adult with isolated nodular splenomegaly.[] One of the twins presented with a history of obsessive-compulsive disorder and slowly progressive inferior limb clumsiness, dysphagia and dysarthria.[] Investigation of patients with isolated splenomegaly is not complete until NPC has been excluded.[]

  • Mucopolysaccharidosis

    […] trunk (dwarfism), dysplasia (abnormal bone size and/or shape) and other skeletal irregularities, thickened skin, enlarged organs such as liver (hepatomegaly) or spleen (splenomegaly[] […] children who have Hunter syndrome but may be underdiagnosed, for patients’ cognitive impairment often prevents them from accurately describing their symptoms. 17,25 Manual clumsiness[] […] slowly to 20-30mg/kg/day in divided doses 40. 40 Adverse effect drowsiness, diplopia, vertigo, araxia, blurred vision, GI upset, skin reaction, lymphadenopathy, eosinophilia, splenomegaly[]

  • Alpha-Mannosidosis

    The earlier system delineated a more severe 'type I,' which shows infantile onset, rapid mental deterioration, hypotonia, splenomegaly, severe dysostosis multiplex, and severe[] Mental and motor development is delayed, but in this context, the progressive course of AM has to be considered: Affected children often appear clumsy, and milestones in speech[] […] onset of the most severe form, type III, begins within the first months of life and includes a quick progression of intellectual disability , liver and spleen enlargement ( splenomegaly[]

  • Niemann-Pick Disease

    RESULTS: Common disease-related morbidities included splenomegaly (96.6%), hepatomegaly (91.4%), liver dysfunction (82.6%), and pulmonary disease (75.0%).[] Niemann-Pick care at Mayo Clinic Symptoms Niemann-Pick signs and symptoms may include: Clumsiness and difficulty walking Excessive muscle contractions (dystonia) or eye movements[] […] after) birth An enlarged spleen and/or liver (hepatosplenamegaly) Difficulty with upward and downward eye movements (Vertical Supranuclear Gaze Palsy) Unsteadiness of gait, clumsiness[]

  • Pernicious Anemia

    Some people with Pernicious Anemia may have an abnormally enlarged liver (hepatomegaly) or spleen (splenomegaly).[] The most common of these are paresthesias, weakness, clumsiness, and an unsteady gait.[] Hepatomegaly and splenomegaly may be present.[]

  • Wilson Disease

    She had no hepatomegaly and no splenomegaly. Breast and pubic hair development was concomitant with Tanner stage 4.[] Signs and symptoms of these problems can include clumsiness, tremors, difficulty walking, speech problems, impaired thinking ability, depression, anxiety, and mood swings.[] […] of the brain, a brownish ring (Kayser-Fleischer ring) at the outer margin of the cornea caused by deposition of copper in the Descemet membrane, cirrhosis of the liver, splenomegaly[]

  • Niemann-Pick Disease Type B

    Most patients initially presented with splenomegaly (78%) or hepatomegaly (73%).[] […] irregular speech Sudden loss of muscle tone which may lead to falls (cataplexy) Tremors Trouble moving the eyes up and down (vertical supranuclear gaze palsy) Unsteady gait, clumsiness[] They may fall frequently and be considered clumsy.[]

  • Rheumatoid Arthritis

    It is extremely rare for RA to present as FS or develop after initially presenting as neutropaenia and splenomegaly.[] Clumsiness is initially experienced, but without due care, this can progress to quadriplegia or even death.[] Other: thyroid disorders, osteoporosis, depression, splenomegaly.[]

  • Duchenne Muscular Dystrophy

    […] heterozygotes for severe defects are affected with thalassemia major or Cooley's anemia, lethal if untreated, and suffer pronounced anemia, bone deformities, and hepatomegaly and splenomegaly[] DMD typically appears between the ages of two with weakness in the pelvis and upper limbs, resulting in clumsiness, frequent falling, an unusual gait and general weakness.[] Additional early signs and symptoms include: Developmental delay Muscle weakness Clumsiness Waddling gait Difficulty or inability to perform activities such as climbing stairs[]

  • Niemann-Pick Disease Type C1

    […] this term) characterized by variable clinical signs, depending on the age of onset, such as prolonged unexplained neonatal jaundice or cholestasis, isolated unexplained splenomegaly[] […] after) birth An enlarged spleen and/or liver (hepatosplenamegaly) Difficulty with upward and downward eye movements (Vertical Supranuclear Gaze Palsy) Unsteadiness of gait, clumsiness[] Isolated splenomegaly may be the presenting symptom in some adolescents or adults.[]

Further symptoms

Similar symptoms