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494 Possible Causes for Clumsiness, Splenomegaly

  • Niemann-Pick Disease Type C

    We report an unusual presentation of NPCD in a young asymptomatic adult with isolated nodular splenomegaly.[ncbi.nlm.nih.gov] One of the twins presented with a history of obsessive-compulsive disorder and slowly progressive inferior limb clumsiness, dysphagia and dysarthria.[ncbi.nlm.nih.gov] Investigation of patients with isolated splenomegaly is not complete until NPC has been excluded.[ncbi.nlm.nih.gov]

  • Mucopolysaccharidosis

    […] trunk (dwarfism), dysplasia (abnormal bone size and/or shape) and other skeletal irregularities, thickened skin, enlarged organs such as liver (hepatomegaly) or spleen (splenomegaly[en.wikipedia.org] […] children who have Hunter syndrome but may be underdiagnosed, for patients’ cognitive impairment often prevents them from accurately describing their symptoms. 17,25 Manual clumsiness[touchneurology.com] […] slowly to 20-30mg/kg/day in divided doses 40. 40 Adverse effect drowsiness, diplopia, vertigo, araxia, blurred vision, GI upset, skin reaction, lymphadenopathy, eosinophilia, splenomegaly[slideshare.net]

  • Alpha-Mannosidosis

    The earlier system delineated a more severe 'type I,' which shows infantile onset, rapid mental deterioration, hypotonia, splenomegaly, severe dysostosis multiplex, and severe[diseaseinfosearch.org] Mental and motor development is delayed, but in this context, the progressive course of AM has to be considered: Affected children often appear clumsy, and milestones in speech[symptoma.com] […] onset of the most severe form, type III, begins within the first months of life and includes a quick progression of intellectual disability , liver and spleen enlargement ( splenomegaly[ipfs.io]

  • Niemann-Pick Disease

    RESULTS: Common disease-related morbidities included splenomegaly (96.6%), hepatomegaly (91.4%), liver dysfunction (82.6%), and pulmonary disease (75.0%).[ncbi.nlm.nih.gov] Niemann-Pick care at Mayo Clinic Symptoms Niemann-Pick signs and symptoms may include: Clumsiness and difficulty walking Excessive muscle contractions (dystonia) or eye movements[mayoclinic.org] […] after) birth An enlarged spleen and/or liver (hepatosplenamegaly) Difficulty with upward and downward eye movements (Vertical Supranuclear Gaze Palsy) Unsteadiness of gait, clumsiness[npuk.org]

  • Pernicious Anemia

    Some people with Pernicious Anemia may have an abnormally enlarged liver (hepatomegaly) or spleen (splenomegaly).[rarediseases.org] The most common of these are paresthesias, weakness, clumsiness, and an unsteady gait.[web.archive.org] Hepatomegaly and splenomegaly may be present.[patient.info]

  • Wilson Disease

    She had no hepatomegaly and no splenomegaly. Breast and pubic hair development was concomitant with Tanner stage 4.[ncbi.nlm.nih.gov] Signs and symptoms of these problems can include clumsiness, tremors, difficulty walking, speech problems, impaired thinking ability, depression, anxiety, and mood swings.[ghr.nlm.nih.gov] […] of the brain, a brownish ring (Kayser-Fleischer ring) at the outer margin of the cornea caused by deposition of copper in the Descemet membrane, cirrhosis of the liver, splenomegaly[whonamedit.com]

  • Niemann-Pick Disease Type B

    Most patients initially presented with splenomegaly (78%) or hepatomegaly (73%).[ncbi.nlm.nih.gov] […] irregular speech Sudden loss of muscle tone which may lead to falls (cataplexy) Tremors Trouble moving the eyes up and down (vertical supranuclear gaze palsy) Unsteady gait, clumsiness[medindia.net] They may fall frequently and be considered clumsy.[rarediseases.org]

  • Rheumatoid Arthritis

    It is extremely rare for RA to present as FS or develop after initially presenting as neutropaenia and splenomegaly.[ncbi.nlm.nih.gov] Clumsiness is initially experienced, but without due care, this can progress to quadriplegia or even death.[en.wikipedia.org] Other: thyroid disorders, osteoporosis, depression, splenomegaly.[patient.info]

  • Duchenne Muscular Dystrophy

    […] heterozygotes for severe defects are affected with thalassemia major or Cooley's anemia, lethal if untreated, and suffer pronounced anemia, bone deformities, and hepatomegaly and splenomegaly[doi.org] DMD typically appears between the ages of two with weakness in the pelvis and upper limbs, resulting in clumsiness, frequent falling, an unusual gait and general weakness.[medterms.com] Additional early signs and symptoms include: Developmental delay Muscle weakness Clumsiness Waddling gait Difficulty or inability to perform activities such as climbing stairs[pfizer.com]

  • Niemann-Pick Disease Type C1

    […] this term) characterized by variable clinical signs, depending on the age of onset, such as prolonged unexplained neonatal jaundice or cholestasis, isolated unexplained splenomegaly[orpha.net] […] after) birth An enlarged spleen and/or liver (hepatosplenamegaly) Difficulty with upward and downward eye movements (Vertical Supranuclear Gaze Palsy) Unsteadiness of gait, clumsiness[npuk.org] Isolated splenomegaly may be the presenting symptom in some adolescents or adults.[rarediseases.org]

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