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358 Possible Causes for Clumsy Gait, Dementia, Pediatric Disorder

  • Hallervorden-Spatz Syndrome

    […] treatments and interventions Covers neurological, neuropsychiatric, and neuromedical disorders across the lifespan (pediatric, adult, and geriatric populations) Includes[books.google.com] , gait (walking) problems, difficulty controlling movement, and speech problems.[rarediseases.org] Serial assessments of a 29-year-old woman showed progressive dementia.[ncbi.nlm.nih.gov]

  • Niemann-Pick Disease

    Unit, Department of Pediatrics, Verona, Italy.[ncbi.nlm.nih.gov] , clumsiness, problems in walking (ataxia) Difficulty in posturing of limbs (dystonia) Slurred, irregular speech (dysarthria) Learning difficulties and progressive intellectual[npuk.org] The NPC1 phenotype is characterized by progressive neuronal dysfunction, including cerebellar ataxia and dementia.[ncbi.nlm.nih.gov]

  • Down Syndrome

    Author information 1 Specialized Medical Center, Department of Pediatric Respiratory Medicine, Sleep Disorders Center, Box 84350, Riyadh 11671, Saudi Arabia.[ncbi.nlm.nih.gov] Less specific symptoms - eg, bladder problems, gait abnormalities or clumsiness - may also indicate need for further investigation.[patient.info] Alzheimer's dementia (AD) is the most common form of dementia in people with Down Syndrome [DS].[ncbi.nlm.nih.gov]

  • Rett Syndrome

    El-Bitar, Degenerative Disorders Primarily of Gray Matter, Swaiman's Pediatric Neurology, 10.1016/B978-1-4377-0435-8.00041-X, (518-543), (2012). Eveline E. O.[doi.org] These mice do not express Mecp2 at all and they display the same symptoms as humans, such as normal development until about 6 weeks, regression, reduced movement, clumsy gait[doi.org] Rett syndrome Rett syndrome w dementia Rett syndrome w dementia w behavioral disturbance Rett's disorder Retts syndrome Retts syndrome with dementia Clinical Information[icd10data.com]

  • Friedreich Ataxia

    Leigh syndrome (subacute necrotizing encephalomyopathy) is a rare, highly morbid and fatal pediatric disorder that results in severe neurological and neuromuscular dysfunction[bioelectron.com] General clumsiness and gait ataxia are usually the first signs to appear, often followed by pyramidal signs, upper-limb ataxia and dysarthria.[orpha.net] Program at Tufts Medical Center in Boston to learn more about treating degenerative brain disease and other types of dementia.[tuftsmedicalcenter.org]

  • Ataxia Telangiectasia

    […] all neurosurgical conditions of infants, children and adolescents, with special expertise in the management of pediatric brain tumors, hydrocephalus, spinal cord disorders[massgeneral.org] Although by history there was mild gait clumsiness in early childhood, the leading problem was that of dystonia with onset at age 15, in the absence of gross gait imbalance[ncbi.nlm.nih.gov] Ataxia-telangiectasia usually progresses to paralysis, dementia, and death, typically by age 30.[merckmanuals.com]

  • Wilson Disease

    disorders Genotype–phenotype correlation Summary Chapter 13: Other organ involvement and clinical aspects of Wilson disease Karolina Dziezyc, Tomasz Litwin and Anna Czlonkowska[elsevier.com] Tremors, involuntary muscle movements, clumsy gait and speech difficulties usually improve with treatment for Wilson's disease.[mayoclinic.org] […] of Wilson’s disease in the United Kingdom Spastic pseudosclerosis (cortico-pallido-spinal degeneration), by Charles Davison (New York), Brain 1932: 55; 247–264 and Severe dementia[doi.org]

  • Infantile Neuroaxonal Dystrophy

    This book provides an update on pediatric neurological disorders with cerebellar involvement.[books.google.com] Of those with childhood onset, one presented with foot drag and dystonia at age ten years and the other two children presented with an unsteady gait at ages six and eight[ncbi.nlm.nih.gov] […] dystrophy is a rare neurodegenerative disorder characterized by infantile onset and rapid progression of psychomotor regression and hypotonia evolving into spasticity and dementia[ncbi.nlm.nih.gov]

  • Metachromatic Leukodystrophy

    Neurology , Center for Childhood White Matter Disorders, VU University Medical Center , Amsterdam , The Netherlands 2 Amsterdam Neuroscience , VU University Medical Center[jnnp.bmj.com] Clumsiness, gait problems, slurred speech, incontinence, bizarre behavior and seizures are also observed.[genedx.com] A case of early-onset adult dementia with family history of dementia is reported, characterised by neuropsychological deficits, suggesting frontal involvement, with mild non[ncbi.nlm.nih.gov]

  • Gordon Holmes Syndrome

    […] inherited disorders and cancer genetics, and on other pediatric adrenal and pituitary disorders.[books.google.de] Patients’ gait becomes clumsy and their speech slurred.[alzforum.org] RNF216) have recently been identified in patients suffering from Gordon Holmes syndrome (GHS), characterized by cognitive decline, dementia, and movement disorders.[ncbi.nlm.nih.gov]

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