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26 Possible Causes for Clumsy Gait, Muscle Biopsy showing Variation In Fiber Size, Pediatric Disorder

  • Duchenne Muscular Dystrophy

    BACKGROUND AND PURPOSE: Duchenne muscular dystrophy (DMD) is a lethal progressive pediatric muscle disorder and genetically inherited as an X-linked disease that caused by[] Additional early signs and symptoms include: Developmental delay Muscle weakness Clumsiness Waddling gait Difficulty or inability to perform activities such as climbing stairs[] Nelson Textbook of Pediatrics. 17th ed. Philadelphia, PA: Elsevier Saunders; 2005:2060-9. Acsadi G. Duchenne Muscular Dystrophy. NORD Guide to Rare Disorders.[]

  • Becker Muscular Dystrophy

    The muscle biopsy was myopathic with increased fiber size variation and many internal nuclei, but no dystrophy. No comorbidity was found.[] Little is known about parental motivations and expectations for clinical trials for rare pediatric disorders.[] Walking on the toes or balls of the feet Clumsiness, falling often Trouble climbing stairs Difficulty rising from a lying or sitting position Larger-than-normal calves that[]

  • Muscular Dystrophy

    Muscle biopsies of the proband showed large variations in muscle fiber size, necrotic and regenerating fibers and an increase in endomysial collagen tissue.[] We offer children and families coordinated care for the diagnosis and treatment of muscular dystrophy and other pediatric neuromuscular disorders.[] Other symptoms include loss of some reflexes, a waddling gait, frequent falls and clumsiness (especially when running), difficulty when rising from a sitting or lying position[]

  • Rigid Spine Syndrome

    Muscle biopsy performed in the older brother showed increase in fibrosis, variation in fiber size, type I fibre predominance, and the presence of central and eccentric cores[] Medicine (2002 – 2010) Assistant Professor of Neurology at University of Pennsylvania School of Medicine (2002 – 2010) Office Location: National Institute of Neurological Disorders[] Pelvic girdle deficit was evident by Gowers sign and a slightly clumsy gait. Muscle stretch reflexes were present.[]

  • Congenital Merosin-Positive Muscular Dystrophy

    (Top) Muscle biopsy showing variation in muscle fiber size with atrophic and hypertrophic fibers.[] Diagnosis of pediatric neuromuscular disorders in the era of DNA analysis. Pediatr Neurol 2000;23: 289–300. [19] Engel 73rd AE.[] In some individuals with CMD, muscle biopsy may only show fiber size variation with absence of or only mild manifestations of fibrosis, necrosis, or regeneration [ Wang et[]

  • Multicore Myopathy with External Ophthalmoplegia

    Such treatment may require the coordinated efforts of a team of medical professionals, such as pediatricians; specialists who diagnose and treat disorders of the skeleton,[] Pelvic girdle deficit was evident by Gowers sign and a slightly clumsy gait. Muscle stretch reflexes were present.[] Epidemiology: Worldwide: Incidence:6 per 100,000 live births or 1/10th of all neuromuscular disorders.[]

  • Arthrogryposis due to Muscular Dystrophy

    Muscle biopsy shows variation in fiber size, a central nucleus, and replacement of muscle tissue by fibrosis and proliferation of adipose tissue.[] A more detailed description of pediatric neuromuscular disorders, including many of the newer genetic discoveries. Muscle Diseases ed. Schapira, AHV and Griggs, RC.[] Pelvic girdle deficit was evident by Gowers sign and a slightly clumsy gait. Muscle stretch reflexes were present.[]

  • Limb-Girdle Muscular Dystrophy Type 1G

    Muscle biopsy showed fiber size variation with very discrete perimyseal fibrosis, and several necrotic fibers with rimmed vacuoles.[] Disorders E-2903 168 Measurement of Health Outcomes in Pediatric Neurologic Disorders E-2910 169 The Influence of Computer Resources on Child Neurology E-2918 170 Education[] […] disturbance Ptosis Ataxia Transient ischemic attack Myotonia Steppage gait Fasciculations Clumsiness Abnormality of the calf musculature Need help with a diagnosis?[]

  • Upper Limb Hypertrophy

    Table 1 Clinical features of reported cases Biopsies (from unilateral cases) showed only a slightly more-than-normal variation in fiber size, without signs of inflammation[] Pediatric Hand and Upper Limb Surgery guides you to the present indications for intervention and care in upper limb pediatric disorders.[] Suspicion of joint or muscle disease (e.g., pain, swelling, stiffness, clumsiness, weakness; this may be suggested if toe-walking is new and a change from a previous gait[]

  • Proximal Myopathy with Extrapyramidal Signs

    Dystrophin-associated protein dysfunction leads to an increased susceptibility to muscle fiber degradation. Muscle biopsy shows abnormal variation in muscle fiber size.[] TABLE 3 Functional Organization of Symptoms Associated With ANS Disorders PEDIATRIC AUTONOMIC DISORDERS Many pediatric autonomic disorders are apparent at birth or within[] , Brooklyn, NY, USA Other articles by this author: De Gruyter Online Google Scholar Abstract Arthrogryposis may result from various neuromuscular or connective tissue disorders[]

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