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57 Possible Causes for Coarse Facial Features, Delayed Female Puberty

  • Mucopolysaccharidosis

    facial features, developmental delay, and an elevated quantitative urine glycosaminoglycan (GAG) level.[] The patient had severe infantile global neurodevelopmental delays, macrocephaly with a prominent forehead, coarse facial features with clear corneas, chronic congestion with[] He did not develop coarse facial features, joint disease, or organomegaly, and his cardiac function remained normal.[]

  • Acromegaly

    A 30-year-old Filipino man presented with a 11-year history of coarse facial features and progressive enlargement of hands and feet.[] This leads to coarse facial features, soft tissue swelling (including the tongue), enlargement of the hands and feet, respiratory problems, hypertension, diabetes mellitus[] Children with gigantism have few soft tissue effects (eg, peripheral edema, coarse facial features), because of their rapid linear growth.[]

  • Juvenile Myxedema

    Children with juvenile hypothyroidism may present with precocious puberty.[] Reproductive system: females present with menstrual irregularities, infertility and anovulation. Males may present with gonadal dysfunctions.[] Musculoskeletal system: muscle stiffness, weakness, cramps, mialgias, arthralgias, joint stiffness and effusions, Carpal Tunnel syndrome and delayed linear bone growth in[]

  • Mucopolysaccharidosis 6

    Presentation Patient with coarse facial features, cardiac murmure, gibbus and dental decay.[] Physical Facial features associated with MPS VI include the following: Coarse facial features (Compare the facial features with those of other family members to best appreciate[] Common symptoms of Maroteaux-Lamy syndrome include: Clouding of the cornea, vision loss Coarse facial features Skeletal and muscular deformities, which can be acute Abnormalities[]

  • Anterior Pituitary Hypofunction

    puberty - adult females have Secondary Amenorrhea; produces osteoporosis, hot flashes (lack of Estrogen), decreased libido - males have impotence, due to decreased libido[] facial features), and if the tumor extends to the optic nerve or optic chiasm, there may be visual field defects.[] Too much prolactin can cause a delay in puberty, a disruption of normal periods in females, and a milky discharge from the nipples.[]

  • Panhypopituitarism

    Left untreated, growth hormone deficiency may lead to short stature and delayed puberty.[] facial features), and if the tumor extends to the optic nerve or optic chiasm, there may be visual field defects.[] […] hormone deficiency can occur with deficiencies of other hormones such as those that control: Production of thyroid hormones Water balance in the body Production of male and female[]

  • Hypogonadotropic Hypogonadism

    HH is not to be confounded with delayed male puberty or delayed female puberty due to physiological variance, nutrient deficiencies, overweight/obesity or systemic diseases[] Clinical features of the syndrome are a coarse face with microcephaly, ocular hypertelorism, flat nasal bridge, upslanting palpebral fissures, bifid uvula and/or cleft palate[] We present the first case of arhinia associated with CHH in a female patient. A 14 years and 8 months female with congenital arhinia presented with delayed puberty.[]

  • Congenital Hypothyroidism

    The symptoms of congenital hypothyroidism may include the following: Puffy face Coarse facial features Dull look Thick protruding tongue Poor feeding Choking episodes Constipation[] He was overweight and underwent precocious puberty.[] Two infants who have coarse facial features and growth and developmental delay. Pediatrics in Review, 24 , 16–21.[]

  • Prader-Willi Syndrome

    In PWS, puberty is usually delayed and fails to complete, with most females never having regular menstrual cycles.[] Adults with Angelman syndrome have distinctive facial features that may be described as " coarse ."[] Both males and females have underdeveloped genitals. Puberty is delayed or incomplete, and most are infertile. What is Prader-Willi syndrome?[]

  • Launois Syndrome

    The more obvious and frequently encountered characteristics include delayed onset of puberty, short stature, small testes, and obesity.[] This syndrome affects males more often than females.[]

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