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70 Possible Causes for Coarse Facial Features, Delayed Female Puberty, Hoarseness

  • Mucopolysaccharidosis

    Vocal cords can also enlarge, resulting in a deep, hoarse voice.[ghr.nlm.nih.gov] facial features, developmental delay, and an elevated quantitative urine glycosaminoglycan (GAG) level.[ncbi.nlm.nih.gov] Patients also develop hepatosplenomegaly, frequent ear infections, and a thickening of the vocal cords and airway that leads to hoarseness and sleep apnea.[invitae.com]

  • Acromegaly

    A 30-year-old Filipino man presented with a 11-year history of coarse facial features and progressive enlargement of hands and feet.[ncbi.nlm.nih.gov] Decreased peripheral vision Easy fatigue Excessive height (when excess GH production begins in childhood) Excessive sweating Headache Heart enlargement, which can cause fainting Hoarseness[nlm.nih.gov] This leads to coarse facial features, soft tissue swelling (including the tongue), enlargement of the hands and feet, respiratory problems, hypertension, diabetes mellitus[ncbi.nlm.nih.gov]

  • Juvenile Myxedema

    Children with juvenile hypothyroidism may present with precocious puberty.[flexikon.doccheck.com] Symptoms of this rare but potentially deadly complication include enlarged tongue, swollen facial features, hoarseness, and physical and mental sluggishness.[medical-dictionary.thefreedictionary.com] […] consumption of goitrogens (e.g. cassava) Symptoms of hypothyroidism Tiredness, weakness Dry skin Feeling cold Hair loss Constipation Weight gain with poor appetite Dyspnea Hoarse[quizlet.com]

  • Mucopolysaccharidosis 6

    Physical Facial features associated with MPS VI include the following: Coarse facial features (Compare the facial features with those of other family members to best appreciate[emedicine.medscape.com] In general, symptoms may include coarse facies, short stature, enlarged liver and spleen, hoarse voice, stiff joints, cardiac disease, but no neurological involvement.[neurology.testcatalog.org] Presentation Patient with coarse facial features, cardiac murmure, gibbus and dental decay.[radiopaedia.org]

  • Launois Syndrome

    The more obvious and frequently encountered characteristics include delayed onset of puberty, short stature, small testes, and obesity.[rarediseases.org] This syndrome affects males more often than females.[rarediseases.org]

  • Congenital Hypothyroidism

    The symptoms of congenital hypothyroidism may include the following: Puffy face Coarse facial features Dull look Thick protruding tongue Poor feeding Choking episodes Constipation[health.cvs.com] He was overweight and underwent precocious puberty.[ncbi.nlm.nih.gov] The child may also have: Poor feeding, choking episodes Constipation Dry, brittle hair Hoarse cry Jaundice (skin and whites of the eyes look yellow) Lack of muscle tone ([mountsinai.org]

  • Hypothyroidism

    Other findings may include pale, yellow skin, thin and brittle hair, coarse facial features, brittle nails, firm swelling of the arms and legs, and mental slowing.[uclahealth.org] Children with juvenile hypothyroidism may present with precocious puberty.[flexikon.doccheck.com] Hypothyroidism symptomatology was similar in both groups, except for a greater frequency of hoarseness in the group with HAH.[ncbi.nlm.nih.gov]

  • Costello Syndrome

    Pubertal Development Six of the eight females in the report had delayed puberty and two had primary amenorrhea.[aadmd.org] We describe a 34-year-old woman with mental retardation, short stature, macrocephaly, a "coarse" face, hoarse voice, and redundant skin with deep palmar and plantar creases[ncbi.nlm.nih.gov] facial features and skeletal and cardiac abnormalities.[ncbi.nlm.nih.gov]

  • Panhypopituitarism

    Left untreated, growth hormone deficiency may lead to short stature and delayed puberty.[mountsinai.org] The general examination found a pale patient, glabrous, very slow, with a sallow complexion of the skin, dry skin, hair removal diffuse, a hoarse voice and hearing loss.[panafrican-med-journal.com] facial features), and if the tumor extends to the optic nerve or optic chiasm, there may be visual field defects.[en.wikipedia.org]

  • Hoffman Syndrome

    She had coarse facial feature, athletic build and hypertrophy of both calf muscles.[endocrine-abstracts.org] […] pseudoprecocious puberty, and multicystic ovaries.[karger.com] He had hoarseness of voice, a dry texture of skin, a macroglossia and an odematous face. Results: Brain imaging findings showed pituitary enlargement .[abstracts.eurospe.org]

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