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268 Possible Causes for Coarse Facial Features, Hoarseness, Prognathism

  • Acromegaly

    Ultimately they cause considerable disability (aside from the need for larger rings, gloves, and shoes) including hoarseness , sleep apnea , joint pain, cardiovascular disease[medicinenet.com] A 30-year-old Filipino man presented with a 11-year history of coarse facial features and progressive enlargement of hands and feet.[ncbi.nlm.nih.gov] Craniofacial soft tissue and skeletal changes including mandibular prognathism and disturbed occlusion are typical manifestations of the disease process.[ncbi.nlm.nih.gov]

  • Mucopolysaccharidosis

    Vocal cords can also enlarge, resulting in a deep, hoarse voice.[ghr.nlm.nih.gov] facial features, developmental delay, and an elevated quantitative urine glycosaminoglycan (GAG) level.[ncbi.nlm.nih.gov] Patients also develop hepatosplenomegaly, frequent ear infections, and a thickening of the vocal cords and airway that leads to hoarseness and sleep apnea.[invitae.com]

  • Mucopolysaccharidosis 1

    Vocal cords can also enlarge, resulting in a deep, hoarse voice.[ghr.nlm.nih.gov] Further common findings are coarse facial features, carpal tunnel syndrome, umbilical and inguinal hernia, and hepatomegaly.[symptoma.com] In general, symptoms may include coarse facies, short stature, enlarged liver and spleen, hoarse voice, stiff joints, cardiac disease, but no neurological involvement.[neurology.testcatalog.org]

  • Launois Syndrome

    We report the first description of a Launois-Bensaude syndrome involving the orbit. Launois-Bensaude syndrome was diagnosed in a 70-year-old-man who presented with severe bilateral proptosis (Hertel value 26mm). We performed a bilateral transpalpebral orbital decompression by resection of intraorbital fat without[…][ncbi.nlm.nih.gov]

  • Alpha-Mannosidosis

    Farber disease, disseminated lipogranulomatosis (ceramidase deficiency): Farber disease starts to manifest in infancy as a hoarse cry or swollen tender joints followed by[emedicine.medscape.com] Clinical symptoms include coarse facial features, skeletal involvement (dysostosis multiplex), hearing disabilities, mental retardation and hepatosplenomegaly.[ncbi.nlm.nih.gov] The facial trait include large head with prominent forehead, rounded eyebrows, flattened nasal bridge, macroglossia, widely spaced teeth, and prognathism.[ncbi.nlm.nih.gov]

  • Gigantism

    Voice is hoarse and affected individuals have a plump, stocky body with pectus excavatum, thoracic scoliosis, hepatosplenomegaly, umbilical and/or inguinal hernias, broad[ncbi.nlm.nih.gov] Children with gigantism may also have coarse facial features which include a larger than normal head, flat nose, and large lips and tongue.[symptoma.com] It appears in childhood and many morphological signs lead us to suspect it: enlarged hands and feet, thick skin, a prominent chin (called prognathism), and an abnormal tendency[health.ccm.net]

  • Gigantism - Acromegaly

    […] hands, jaw, tongue, and glands in the skin, which leads to excessive sweating and body odor), weakness, fatigue, thickening of the skin, joint pain and swelling, headache, hoarseness[emaxhealth.com] Physical examination showed coarse facial features, spade-like hands and feet, pitting pedal edema, galactorrhoea, and features of congestive cardiac failure.[smartypance.com] The mandible also characteristically enlarges resulting in prognathism and gaps between the teeth 10 .[radiopaedia.org]

  • Simpson Dysmorphia Syndrome

    […] spastic paraplegia type 8 Autosomal dominant spastic paraplegia type 9 Autosomal dominant striatal neurodegeneration Autosomal recessive Charcot-Marie-Tooth disease with hoarseness[se-atlas.de] facial features, widely spaced eyes, a short nose with anteverted nares, gingival overgrowth, a wide mouth, short limbs with short distal phalanges, and a small penis.[zora.uzh.ch] […] megacephaly - Macroglossia / tongue protrusion / proeminent / hypertrophic - Macrostomia / big mouth - Multicystic kidney / renal dysplasia - Postaxial polydactyly (hand) - Prognathism[csbg.cnb.csic.es]

  • Hypertrichotic Osteochondrodysplasia

    Vertebral fusion Supernumerary nipple Nephroblastoma Hydroureter Vertebral segmentation defect Preauricular pit Relative macrocephaly Abnormality of the voice Duodenal atresia Hoarse[mendelian.co] […] of head or neck Anteverted nares Coarse facial features Curly eyelashes Epicanthus Large sella turcica Long philtrum Low anterior hairline Low posterior hairline Macrocephaly[familydiagnosis.com] […] blackout *syncope *lipopsyche 【失声症】*aphonia 【失読症】*alexia *dyslexia *typhlolexia *word blindness ( 読字障害、読字不能) 【失認症】*agnosia (湿) 【湿性壊疽】*moist gangrene *wet gangrene 【湿性嗄声】*wet hoarseness[medo.jp]

  • Hyperpituitarism

    Symptoms and Signs The symptoms of the condition include headaches, double vision, excessive sweating, hoarseness, sleep apnea and muscle weakness.[medigest.uk] facial features, including frontal bossing and prognathism Hyperhidrosis Menstrual irregularities Peripheral neuropathies (eg, carpal tunnel syndrome) Cardiovascular disease[emedicine.medscape.com] Additional features include macrocephaly, prognathism, frontal bossing, irregular menses in women, and hyperhidrosis.[symptoma.com]

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