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60 Possible Causes for Coarse Facial Features, Hoarseness, Spinal Cord Compression

  • Mucopolysaccharidosis

    Spinal cord compression (SCC) is a known complication of mucopolysaccharidosis type VI (MPS VI) secondary to atlantoaxial subluxation, craniovertebral stenosis, posterior[ncbi.nlm.nih.gov] Vocal cords can also enlarge, resulting in a deep, hoarse voice.[ghr.nlm.nih.gov] facial features, developmental delay, and an elevated quantitative urine glycosaminoglycan (GAG) level.[ncbi.nlm.nih.gov]

  • Mucopolysaccharidosis 2

    […] hearing impairment, sleep apnoea, hydrocephalus, carpal tunnel syndrome, spinal cord compression and cervical myelopathy.[touchneurology.com] Common signs and symptoms include a large head, full lips, large rounded cheeks, a broad nose, hoarse voice and an enlarged tongue (macroglossia).[symptoma.com] Other symptoms may include carpal tunnel syndrome, coarse facial features, deafness, hairy body (hypertrichosis), joint stiffness, and a large head (macrocephaly).[secure.ssa.gov]

  • Mucopolysaccharidosis 1

    Stiffened joints Skeletal (bone) Carpal tunnel syndrome Heart (valve) disease Recurrent upper airway infections Lung disease/sleep apnea Corneal clouding Spinal cord compression[mps1disease.com] Vocal cords can also enlarge, resulting in a deep, hoarse voice.[ghr.nlm.nih.gov] Further common findings are coarse facial features, carpal tunnel syndrome, umbilical and inguinal hernia, and hepatomegaly.[symptoma.com]

  • Acromegaly

    OLF is a potential spinal manifestation of acromegaly and should be considered in the differential diagnosis of spinal stenosis or spinal cord compression in the context of[ncbi.nlm.nih.gov] Decreased peripheral vision Easy fatigue Excessive height (when excess GH production begins in childhood) Excessive sweating Headache Heart enlargement, which can cause fainting Hoarseness[nlm.nih.gov] A 30-year-old Filipino man presented with a 11-year history of coarse facial features and progressive enlargement of hands and feet.[ncbi.nlm.nih.gov]

  • Launois Syndrome

    […] the forearm or ankle, or cord compression if in dural/medullary components of the spinal cord.[unboundmedicine.com] Lipomas can cause respiratory distress due to bronchial obstruction of major airways, GI obstruction or bleeding, neuropathic symptoms from compression in locations such as[unboundmedicine.com]

  • Mucopolysaccharidosis 6

    Major sequelae include spinal cord compression, degenerative joint disease, contractures, and arthritis.[symptoma.com] In general, symptoms may include coarse facies, short stature, enlarged liver and spleen, hoarse voice, stiff joints, cardiac disease, but no neurological involvement.[neurology.testcatalog.org] Presentation Patient with coarse facial features, cardiac murmure, gibbus and dental decay.[radiopaedia.org]

  • Mucopolysaccharidosis 4

    Although the CNS and peripheral nerves are primarily not affected, the bone defects may result in neurological symptoms such as spinal cord compression.[centogene.com] […] deformity, dorsolumbar kyphosis, increased anteroposterior diameter of chest, pectus excarinatum, waddling gait, pot belly, valgus deformity of both upper and lower limbs and hoarse[apicareonline.com] Patients may also have coarse facial features, although this is usually milder than that seen in MPSI or MPSII.[genedx.com]

  • Mucopolysaccharidosis 1H

    Cord Compression Hepatosplenomegaly/Splenomegaly Inguinal or Umbilical Hernia Hearing Loss Cognitive Impairment Growth Deficiencies Coarse Facial Features Communicating Hydrocephalus[mps1disease.com] Vocal cords can also enlarge, resulting in a deep, hoarse voice.[ghr.nlm.nih.gov] […] hairy skin all over the body, a tuft of hair in the parietal region, coarse facial features and a prominent forehead with a large tongue, hepatosplenomegaly and skeletal[dx.doi.org]

  • McCune-Albright Syndrome

    Kyphotic deformity and spinal cord compression may occur.[emedicine.medscape.com] These changes decrease voice pitch, giving it a hollow quality and a coarse hoarseness [29] .[journals.lww.com] Growth hormone – Some patients have too much pituitary growth hormone, which causes coarse facial features, larger hands and feet, and arthritis.[houghton.moneomed.com]

  • Mucopolysaccharidosis 1 H-S

    Cord Compression Hepatosplenomegaly/Splenomegaly Inguinal or Umbilical Hernia Hearing Loss Cognitive Impairment Growth Deficiencies Coarse Facial Features Communicating Hydrocephalus[mps1disease.com] Vocal cords can also enlarge, resulting in a deep, hoarse voice.[icdlist.com] facial features, hepatosplenomegaly, multiple radiographic evidence of dysostosis multiplex, manifestations of mild valvular heart disease as per echocardiography, and abnormally[scopemed.org]

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