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20 Possible Causes for Coarse Facial Features Over Time

  • Pallister-Killian Syndrome

    Summary Epidemiology Incidence is uncertain and is estimated around 1/25,000. Clinical description A number of cases are prenatally diagnosed because of abnormal ultrasonic findings, and abnormal presentation at birth is usual. Most common signs include facial dysmorphism, rhizomelic limb shortness, small hands and feet[…][orpha.net]

  • Primary Hypertrophic Osteoarthropathy

    Over time, more pronounced coarse facial features developed.[jrheum.org]

  • Macrocephaly

    The facial features in some individuals tend to coarsen over time, whereas those with extremely large deletions may have coarse features at birth [ Ying et al 1982, Muller[ncbi.nlm.nih.gov]

  • Mucopolysaccharidosis 2

    over a more protracted time period.[emedicine.medscape.com] Hearing impairment, joint stiffness, coarse facial features, upper airway disease, and carpal tunnel syndrome as seen in MPS IIA remain hallmarks in MPS IIB, but become evident[emedicine.medscape.com]

  • Mucopolysaccharidosis 1H

    time Thick, coarse facial features with low nasal bridge Signs and tests [ edit ] Genetic testing for the alpha-L-iduronidase (IDUA) gene Urine tests for extra mucopolysaccharides[en.wikibooks.org] time Thick, coarse facial features with low nasal bridge Diagnosing Hurler Syndrome A diagnosis of Hurler syndrome can be achieved using the following exams and tests.[disabled-world.com] […] greatly over time.[mps1disease.com]

  • Mucolipidosis

    Their facial features become slightly thickened or "coarse" over time. Affected individuals may also develop frequent ear and respiratory infections.[centogene.com] Osteoporosis and progressive joint problems also cause pain in people with mucolipidosis III alpha/beta, which becomes more severe over time.[centogene.com]

  • Mucolipidosis Type 1

    Their facial features become slightly thickened or "coarse" over time. Affected individuals may also develop frequent ear and respiratory infections.[centogene.com] Osteoporosis and progressive joint problems also cause pain in people with mucolipidosis III alpha/beta, which becomes more severe over time.[centogene.com]

  • Gorlin Syndrome

    The facial features in some individuals tend to coarsen over time, whereas those with extremely large deletions may have coarse features at birth [ Ying et al 1982, Muller[ncbi.nlm.nih.gov]

  • Mucopolysaccharidosis 1

    time in severe MPS I Thick, coarse facial features with low nasal bridge In some states, babies are tested for MPS I as part of the newborn screening tests.[medlineplus.gov] Abnormal bones in the spine Claw hand Cloudy corneas Deafness Halted growth Heart valve problems Joint disease, including stiffness Intellectual disability that gets worse over[medlineplus.gov]

  • Mucopolysaccharidosis 4

    " facial features, such as a bulging forehead Cloudy vision Heart valve issues and heart murmur Enlarged liver Over time, MPS IV may cause serious complications, including[everydayhealth.com] […] being double-jointed) Knock-knees, or knees that angle inward and touch each other when the legs are straight Teeth spaced widely apart Abnormally large head (macrocephaly) "Coarse[everydayhealth.com]

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