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118 Possible Causes for Cognitive Defect, Deep White Matter Changes

  • Hyponatremia

    In the brain MRI, millimeter-sized chronic microangiopathic ischemic signal changes were observed in the periventricular deep white matter; no mass image was seen in the pituitary[reumatologiaclinica.org]

  • Stroke

    Early features include: loss of grey-white matter differentiation, and hypoattenuation of deep nuclei: lentiform nucleus changes seen as early as 1 hour after occlusion, visible[radiopaedia.org]

  • Cerebral Thrombosis

    Bilateral or widespread superficial dural sinus thrombosis with focal cortical or subcortical white matter infarction, often hemorrhagic Deep sinus thrombosis with thalamic[clinicaladvisor.com] Associated imaging abnormalities range from least to more severe as follows: Focal or unilateral superficial dural sinus thrombosis without ischemic or hemorrhagic changes[clinicaladvisor.com]

  • Dementia

    It may be particularly related to frontal deep white matter lesions. 16 Cognitive and behavioral changes in SVD are due to disruption of the frontal cortico-subcortical circuit[doi.org] In advanced AD pathology, synaptic dysfunction is another structural defect associated with a decline in memory ( 35 Terry RD.[doi.org] Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol. 1991 ; 30: 572 – 80.[doi.org]

  • Alcohol Dementia

    The CT showed prominent sulci and gyri with deep white matter changes. There were no other abnormalities.[gponline.com]

  • Binswanger Disease

    OBJECTIVES: To analyse the diagnostic and prognostic value of periventricular hyperintensity (PVH) and deep white matter hyperintensity (DWMH) magnetic resonance imaging ([ncbi.nlm.nih.gov] These cases can be distinguished from general paralysis first by the stability of their deficits, secondly by the peculiar development of the cognitive defect (decrease of[www2.psykl.med.tum.de] This type of injury will not typically result in defects of multiple cognitive domains, as occur in dementia.[aafp.org]

  • Multi-Infarct Dementia

    Several pathogenic mechanisms appear implicated in the causation the deep white matter changes of Binswanger's disease, and hypoxia-ischemia resulting from watershed injury[web.archive.org] […] provide important information Cardiac auscultation: Cardiac rhythmic and valvular abnormalities may be detected Neurologic assessment: Spasticity, hemiparesis, visual field defects[emedicine.com] Periventricular and deep white matter changes on T 2 -weighted MRI that are excessive for age 2 … … 3. Focal changes in electroencephalographic studies 3 27 1 31.8 D.[doi.org]

  • Primary Progressive Multiple Sclerosis

    Consistent with this reduction, we showed that changes in diffusion indices of tissue damage within major clinically relevant white matter (corpus callosum and corticospinal[ncbi.nlm.nih.gov] […] tract) and deep grey matter (thalamus) structures were significantly reduced during the treatment phase (P 0.02, corrected).[ncbi.nlm.nih.gov]

  • Metabolic Encephalopathy

    white matter changes may be seen, with the appearance of hyperintensity on T2 sequences in the region of internal capsule, corona radiata, and splenium of corpus callosum[neurologyindia.com] […] memory deficit with preservation of remote memory and out of proportion to other cognitive defects.[dartmouth.edu] […] be registered, whereas in T2 sequence, diffuse edema in the cortical regions (in the form of hyperintensity of perirolandic and occipital regions) can be detected. [43] Deep[neurologyindia.com]

  • Normal Pressure Hydrocephalus

    White matter changes (WMC) INPH is known to be associated with deep white matter changes (DWMC) and smooth periventricular hyperintensity (PVH) [ 51 ] on MRI ( Figure 2B )[intechopen.com] White-matter changes: A distinction is drawn between periventricular and “deepwhite matter changes ( e49, e50 ); only the former are considered a sign of NPH.[ncbi.nlm.nih.gov] white matter.[ajnr.org]

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