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1,599 Possible Causes for Cognitive Defect, Dull Facial Expression, Wide Space Between the First and Second Toe

  • Down Syndrome

    A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org] However, in contrast to cognitive and cardiac defects, these motor and muscle phenotypes in DS have not been documented in detail in terms of either penetrance or severity[doi.org] spacing, often with a deep plantar groove between the first and second toes.[doi.org]

  • Dementia

    In advanced AD pathology, synaptic dysfunction is another structural defect associated with a decline in memory ( 35 Terry RD.[doi.org] Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol. 1991 ; 30: 572 – 80.[doi.org]

    Missing: Wide Space Between the First and Second Toe
  • Myxedema

    The patient loses facial expression, and an appearance of imbecility is quickly observed.[henriettes-herb.com] He is stupid, inactive, dull of comprehension , is difficult to interest in the surroundings, or he takes an interest in very childish things.[henriettes-herb.com]

    Missing: Wide Space Between the First and Second Toe
  • Juvenile Myxedema

    الصفحة 247 - M, et al. Assessment of the skeletal status by peripheral quantitative computed tomography of the forearm: Short-term precision in vivo and comparison to dual x-ray absorptiometry. ‏ الصفحة 421 - Stener B. Displacement of the ruptured ulnar collateral ligament of the metacarpo-phalangeal joint of[…][books.google.com]

    Missing: Wide Space Between the First and Second Toe
  • Congenital Hypothyroidism

    […] diagnosed late may have substantial cognitive and behavioral defects 34.[slideshare.net] Defects in memory and attention may also be present.[emedicine.medscape.com] In contrast, infants who are diagnosed late may have substantial cognitive and be-havioral defects ranging from mild to severe, depending on the severity of the CH and the[slideshare.net]

    Missing: Wide Space Between the First and Second Toe
  • Sporadic Goitrous Cretinism

    Abstract WE have found that the short-term administration of pharmacological doses of thyroactive substances (90 mg triiodothyroacetic acid or equivalent amounts of desiccated thyroid within 9 days) produced in three sibs with sporadic goitrous cretinism prolonged clinical remissions with normalization of thyroid[…][nature.com]

    Missing: Wide Space Between the First and Second Toe
  • Sleep Apnea

    In both patients, elevated creatine phosphokinase, a dull facial expression, peripheral edema and slow speech were recognized, and these symptoms were suggestive of hypothyroidism[ncbi.nlm.nih.gov]

    Missing: Wide Space Between the First and Second Toe
  • Parkinson's Disease

    A modified card sorting test sensitive to frontal lobe defects. Cortex 1976 ;12: 313 - 324 31. Mattis S.[oadoi.org] Heterogeneity of cognitive impairment in progressive supranuclear palsy, Parkinson's disease, and Alzheimer's disease. Neurology 1986 ;36: 1179 - 1185 30. Nelson HE.[oadoi.org]

    Missing: Wide Space Between the First and Second Toe
  • Mental Retardation

    They are associated with cognitive defects, autism at different stages in children.[newhealthguide.org] Further studies will explore the specific mechanisms whereby PHF8 alterations lead to mental retardation and midline defects.[ncbi.nlm.nih.gov] However, in severe cases, malformations of the central nervous system include hydranencephaly, neural tube defects and microcephaly.[symptoma.com]

    Missing: Wide Space Between the First and Second Toe
  • Meningovascular Syphilis

    Salient features are coarse movements, dull facial expression, increased muscle reflexes and pupil abnormalities. At the late stage seizures may occur.[alzheimer-europe.org] Episodic forgetfulness is usually the first cognitive change, followed by defective concentration, reduction of interests and mental and physical slowing in the manner typical[kraeplinpsychiatry.wordpress.com] […] pupillary defect (tonic pupil in the left, a certain degree of mydriasis with diminished reaction to light), parkinsonism, myoclonus and cerebellar ataxia.[bmcresnotes.biomedcentral.com]

    Missing: Wide Space Between the First and Second Toe

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