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39 Possible Causes for Cognitive Defect, Persistent Lactic Acidosis

  • Hypoglycemia

    BACKGROUND: Postprandial hyperinsulinemic hypoglycemia (PHH) is an increasingly recognized complication of gastric bypass surgery in obese adults, distinct from the "dumping syndrome". CASE PRESENTATION: Upon birth, primary repair of esophageal atresia was performed, and at the age of 14 months definite esophageal[…][ncbi.nlm.nih.gov]

  • MELAS Syndrome

    MELAS syndrome was suspected postoperatively owing to persistent lactic acidosis and neurological symptoms.[ncbi.nlm.nih.gov] […] impairment, migraines, depression, cardiomyopathy, cardiac conduction defects, and diabetes mellitus.[ncbi.nlm.nih.gov] There is persistent lactic acidosis. Histologically, there are ragged red fibres on muscle biopsy and accumulation of abnormal mitochondria in smooth muscle.[omicsonline.org]

  • Acidosis

    Hyperlactatemia is defined as a persistent, mild to moderate (2-4 mmol/L) increase in blood lactate concentration without metabolic acidosis , whereas lactic acidosis is characterized[emedicine.medscape.com] Symptoms of Lactic Acidosis The symptoms of lactic acidosis include: Persistent nausea, vomiting, and abdominal (belly) pain Unexplained tiredness Shortness of breath Rapid[thebody.com] acidosis ensue, commonly referred to as lactic acidosis. [1, 2] (See Etiology .)[emedicine.medscape.com]

  • Leigh's Disease

    All children developed progressive neurological deterioration and persistent metabolic lactic acidosis, which was treated with sodium bicarbonate, and the 1st patient needed[ncbi.nlm.nih.gov] Abnormality of cognition Cognitive abnormality Cognitive defects Cognitive deficits Intellectual impairment Mental impairment More information about the genes responsible[rarediseases.info.nih.gov] Treatment: See Beta-oxidation Defects . Links: OMIM Long Name: Mitochondrial Encephalomyopathy Lactic Acidosis and Strokelike Episodes.[umdf.org]

  • Isolated Complex I Deficiency

    acidosis.[ncbi.nlm.nih.gov] Patient #6 showed exercise intolerance and SDH-defective myopathy.[ojrd.biomedcentral.com] Treatment: See Beta-oxidation Defects. Links: OMIM Long Name: Mitochondrial Encephalomyopathy Lactic Acidosis and Strokelike Episodes.[umdf.org]

  • Pyridoxine Dependency Syndrome

    Persistent lactic acidosis in neonatal hypoxic-ischaemic encephalopathy correlates with EEG grade and electrographic seizure burden.[demosmedical.com] […] gene in PDS may include cognitive and other neuropsychologic impairment. [8] Some suggest that PDS is possibly caused by a glutamic acid decarboxylase (GAD) abnormality;[emedicine.medscape.com] Pathophysiology PDS is an autosomal recessive inborn disorder of metabolism. [1, 9, 10] Some studies suggest that, as well as seizure activity, the neurobehavioral phenotype of the defective[emedicine.medscape.com]

  • Combined Oxidative Phosphorylation Defect Type 14

    lactic acidosis in individuals with MELAS syndrome).[emedicine.medscape.com] […] decline, seizures, hearing loss, and cardiac conduction defects.[msdmanuals.com] Treatment: See Beta-oxidation Defects . Links: OMIM Long Name: Mitochondrial Encephalomyopathy Lactic Acidosis and Strokelike Episodes.[umdf.org]

  • Spastic Quadriplegic Cerebral Palsy Type 2

    In addition, patients do not develop severe metabolic crises in the neonatal period as observed in other organic acidurias, but may show persistent lactic acidosis, most likely[mendelian.co] The condition may be congenital or acquired; MRI usually shows abnormalities of the opercular cortex, with dysgenesis (including defects of neuronal migration) of the perisylvian[adc.bmj.com] […] infantile SCN9A Paroxysmal extreme pain disorder SLC2A1 Epilepsy, idiopathic generalized, GLUT1 deficiency syndrome, Stomatin-deficient cryohydrocytosis with neurologic defects[genda.com.ar]

  • Neonatal Sepsis

    , and hemodynamic instability (tachycardia bursts, unstable blood pressure with frequent drops below 60/40 mm Hg), unsatisfactory control of acidosis and lactic acid, which[karger.com] Cognitive defects, cerebral palsy, hearing loss, nephrotoxicity and other neurodevelopmental disabilities can also occur (Stoll et al, 2004).[jfhc.co.uk] […] remained persistently above 8 mmol/l (normal value Net improvement of the patient's hemodynamic condition, the resolution of the tachycardia burst, a rapid improvement of[karger.com]

  • Precursor-Cell Lymphoblastic Leukemia

    He was admitted with a possible diagnosis of acute pericarditis and lactic acidosis. Sodium bicarbonate replacement did not improve the lactic acidosis.[ncbi.nlm.nih.gov] defects Patient Education Ensure that the patient's parents and guardians understand that ALL usually does not have a known cause, that accurate stratification helps guide[emedicine.medscape.com] Lactic acidosis normalized after initiation of chemotherapy.[ncbi.nlm.nih.gov]

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