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1,582 Possible Causes for Cognitive Developmental Delay, Delayed Dentition, Wide Space Between the First and Second Toe

  • Down Syndrome

    A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org] […] variants: or Down's syndrome Definition of Down syndrome : a congenital condition characterized especially by developmental delays, usually mild to moderate impairment in[merriam-webster.com] spacing, often with a deep plantar groove between the first and second toes.[dx.doi.org]

  • Seckel Syndrome

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] , and delayed eruption of the permanent dentition.[ncbi.nlm.nih.gov] Wide space between first and second toes Wide-spaced big toe Widely spaced 1st-2nd toes Widely spaced first and second toes Widened gap 1st-2nd toes Widened gap first and[rarediseases.info.nih.gov]

  • Atelosteogenesis Type 2

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Developmental delay may be temporal or permanent; for example, in achondroplasia, motor development may be delayed in the first 2 years, due to macrocephaly and ligamentous[musculoskeletalkey.com] dentition, and hypomyelination, see Pol III-related leukodystrophy ataxia, fatal X-linked, with deafness and loss of vision, see Arts syndrome ataxia-deafness-optic atrophy[mygenomics.com]

  • SHORT Syndrome

    Developmental milestones and cognition are normal.[uniprot.org] dentition.[ncbi.nlm.nih.gov] Delayed dentition, hypodontia, enamel hypoplasia, malocclusion and multiple dental caries are frequently reported. Ophthalmic anomalies (e.g.[orpha.net]

    Missing: Wide Space Between the First and Second Toe
  • Helsmoortel-van der Aa Syndrome

    To identify most (if not all) conditions with ID, we searched for entries with either “mental retardation” or “developmental delay”, “intellectual disability”, and “cognitive[f1000research.com] The gingival enlargement usually begins at the time of eruption of the permanent dentition, but can develop with the eruption of the primary dentition.[contempclindent.org] , behavioral problems, or developmental delay.[eyewiki.aao.org]

    Missing: Wide Space Between the First and Second Toe
  • Iron Deficiency

    The latter include decreased aerobic work performance, hair loss, developmental delay, cognitive and intellectual impairment, adverse pregnancy outcome, and impaired immune[www2.gov.bc.ca] Reversal of developmental delays in iron-deficient anaemic infants treated with iron. Lancet 1993;341(8836):1-4. Lozoff B, Jimenez E, Wolf AW.[cdc.gov] Iron deficiency and cognitive function. Annu Rev Nutr 1993;13:521-37. Idjradinata P, Pollitt E.[cdc.gov]

    Missing: Delayed Dentition Wide Space Between the First and Second Toe
  • Wiedemann-Rautenstrauch Syndrome

    Subsequent tooth development (dentition) is delayed and impaired.[rarediseases.org]

    Missing: Wide Space Between the First and Second Toe
  • Drayer Syndrome

    60 33 frequent (33%) Frequent (79-30%) HP:0001263 11 abnormality of the dentition 60 33 frequent (33%) Frequent (79-30%) HP:0000164 12 delayed speech and language development[malacards.org] 8 coarse facial features 60 33 frequent (33%) Frequent (79-30%) HP:0000280 9 hearing impairment 60 33 frequent (33%) Frequent (79-30%) HP:0000365 10 global developmental delay[malacards.org]

    Missing: Wide Space Between the First and Second Toe
  • Macrocephaly-Developmental Delay Syndrome

    space between first and second toes (sandal toes) clinodactyly of the fifth finger All of these are found in individuals without DS.[medicalhomeportal.org] Since the early 2000s, PTEN germline mutation haploinsufficiency has been reported in association with autism, variable cognitive impairment and developmental delay in the[consultqd.clevelandclinic.org] The eye's disorders such as myopia, astigmatism, nystagmus or strabismus are characteristic and so are delayed teething and defects of dentition.[ispub.com]

  • Cutis Laxa

    Other reported osteoarticular features are: a wide space between the first and second toes; talipes equinovarus; metatarsus adductus; genu recurvatum or genu valgum; flat[scielo.br] Despite delays in developmental milestones and language, affected children are said to be cheerful and outgoing. Neurologic findings Cognitive.[ncbi.nlm.nih.gov] Early development was normal, except language and dentition delayed. There was no family history.[panafrican-med-journal.com]