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2,008 Possible Causes for Cognitive Developmental Delay, Drop Attacks, Severe Recurrent Orthostatic Hypotension

  • Orthostatic Hypotension

    A 71-year-old man, who was diagnosed with familial amyloidosis type I, was admitted for treatment of severe orthostatic hypotension associated with recurrent syncopal attacks[ncbi.nlm.nih.gov] OH is defined specifically as a 20mmHg drop in systolic, and/or a 10mmHg drop in diastolic BP within 3 min of standing.[clinicaltrials.gov] Abstract A 60-year-old male with recurrent syncopal attacks presented with orthostatic hypotension on the head-up tilt test.[ncbi.nlm.nih.gov]

    Missing: Cognitive Developmental Delay
  • Early Infantile Epileptic Encephalopathy Type 6

    Disease onset occurs in the first year of life, followed by developmental delay with cognitive and behavioral dysfunction and substantially elevated risk of premature death[ncbi.nlm.nih.gov] NOTE: Myoclonic-atonic seizures are one type of seizure that can result in a "drop attack" (also known as astatic seizure), other causes of drop attacks include myoclonic[medlink.com] delay or cognitive outcome did not differ between both groups.[pediatricneurologybriefs.com]

    Missing: Severe Recurrent Orthostatic Hypotension
  • Syncope

    However, a syncopal episode associated with normal sinus rhythm may be due to several disorders such as orthostatic hypotension, vasovagal or carotid sinus reflexes, or even[omicsonline.org] It has many causes, and is distinct from vertigo, seizures, coma, falls, psychogenic pseudosyncope, drop attacks, transient ischaemic attacks, and states of altered consciousness[bestpractice.bmj.com] Autonomic failure 8.1.2 Epilepsy and ictal asystole 8.1.3 Cerebrovascular disorders 8.1.4 Migraine 8.1.5 Cataplexy 8.1.6 Drop attacks 8.2 Neurological tests 8.2.1 Electroencephalography[escardio.org]

    Missing: Cognitive Developmental Delay
  • Micturition Syncope

    Syncope is usually not recurrent; however, recurrent micturition syncope has been reported with bladder neck obstruction, severe chronic orthostatic hypotension, and paroxysmal[ncbi.nlm.nih.gov] Differential diagnosis of Blackouts • Syncope • Epilepsy • Psychogenic non-epileptic seizures •Cataplexy  Drop attack • Transient CSF obstruction • Transient ischaemic attack[slideshare.net] Cerebrovascular disease is an uncommon cause of syncope, In patients with vertebrobasilar transient ischemic attacks or subclavian steal syndrome, syncope and drop attacks[ncbi.nlm.nih.gov]

    Missing: Cognitive Developmental Delay
  • Epilepsy

    BACKGROUND: Congenital or early-onset brain structural lesions often cause contralateral hemiparesis, cognitive deficits, developmental delays, and seizures.[ncbi.nlm.nih.gov] Atonic seizures, also known as drop attacks, drop seizures or akinetic epileptic drop attacks, may involve a sudden loss of muscle tone, a head drop or leg weakening.[uchospitals.edu] Children with symptomatic epilepsy and devastating epilepsy syndromes have high rates of global developmental delay, hyperactivity, and autistic symptoms.[ncbi.nlm.nih.gov]

    Missing: Severe Recurrent Orthostatic Hypotension
  • Absence Seizure

    As with the gabapentin study, many of the children were developmentally delayed or intellectually disabled.[childneurologyfoundation.org] Seizures or Drop Attacks brief seizures, short duration cause an unexpected and rapid fall to the ground can result from tonic (stiffening) or atonic (sudden loss of tone[thebarrow.org] Atonic (also called a drop attack) : Atonic seizures cause loss of muscle tone. In fact, Atonic literally means “without tone” so the muscles become weak.[efepa.org]

    Missing: Severe Recurrent Orthostatic Hypotension
  • Idiopathic Generalized Epilepsy

    These syndromes do not respond well to antiseizure drug therapy and are commonly associated with developmental delays, as well as motor and cognitive impairments.[amboss.com] This case study highlights the need to consider psychological factors when evaluating otherwise unexplained drop attacks.[ncbi.nlm.nih.gov] Patient: This 15-year-old, mentally retarded girl developed drop attacks at the age of 3.25 years, later clonic and clonic-tonic, as well as myoclonic seizures.[thieme-connect.com]

    Missing: Severe Recurrent Orthostatic Hypotension
  • Early Infantile Epileptic Encephalopathy Type 2

    Patients with a SYNGAP1 mutation have a developmental delay, cognitive regression and some patients have a autism.[molgen.ua.ac.be] Individuals with the disorder may experience several different types of seizures including drop attacks, tonic seizures, absence, and convulsions.[kcnq2cure.org] developmental delay and intellectual disability.[ncbi.nlm.nih.gov]

    Missing: Severe Recurrent Orthostatic Hypotension
  • Sick Sinus Syndrome

    Diagnostic criteria were proposed in 2012 noting that most affected individuals have short fifth fingers with absent or underdeveloped nails, developmental and/or cognitive[rarediseases.org] delays, and facial features such as a wide mouth and broad nose.[rarediseases.org]

    Missing: Severe Recurrent Orthostatic Hypotension
  • Early Infantile Epileptic Encephalopathy Type 17

    […] featuring moderate developmental delay associated with complex stereotypies, mainly facial dyskinesia, and mild epilepsy.[genecards.org] In contrast, generalized seizure types predominated in our families including tonic-clonic, absence, myoclonic, tonic and atonic seizures.[dx.doi.org] Clinical features range from severe motor and cognitive impairment with marked choreoathetosis, self-injurious behavior and epileptic encephalopathy, to a milder phenotype[genecards.org]

    Missing: Severe Recurrent Orthostatic Hypotension