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1,266 Possible Causes for Cognitive Developmental Delay, Flat Facial Profile, Wide Space Between the First and Second Toe

  • Down Syndrome

    A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org] […] variants: or Down's syndrome Definition of Down syndrome : a congenital condition characterized especially by developmental delays, usually mild to moderate impairment in[merriam-webster.com] How Down Syndrome Affects Kids Kids with Down syndrome tend to share certain physical features such as a flat facial profile, an upward slant to the eyes, small ears, and[kidshealth.org]

  • Atelosteogenesis Type 2

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Developmental delay may be temporal or permanent; for example, in achondroplasia, motor development may be delayed in the first 2 years, due to macrocephaly and ligamentous[musculoskeletalkey.com] Note moderate short stature, flat facial profile (fetal face–like appearance), short forearms, and small hands.[thehealthscience.com]

  • Seckel Syndrome

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Wide space between first and second toes Wide-spaced big toe Widely spaced 1st-2nd toes Widely spaced first and second toes Widened gap 1st-2nd toes Widened gap first and[rarediseases.info.nih.gov] Wide space between first and second toes Widely spaced 1st-2nd toes Widely spaced first and second toes Widened gap 1st-2nd toes Widened gap first and second toe [ more ][rarediseases.info.nih.gov]

    Missing: Flat Facial Profile
  • Iron Deficiency

    The latter include decreased aerobic work performance, hair loss, developmental delay, cognitive and intellectual impairment, adverse pregnancy outcome, and impaired immune[www2.gov.bc.ca] Reversal of developmental delays in iron-deficient anaemic infants treated with iron. Lancet 1993;341(8836):1-4. Lozoff B, Jimenez E, Wolf AW.[cdc.gov] Iron deficiency and cognitive function. Annu Rev Nutr 1993;13:521-37. Idjradinata P, Pollitt E.[cdc.gov]

    Missing: Flat Facial Profile Wide Space Between the First and Second Toe
  • Robinow Syndrome

    Developmental assessment every three months in infancy and every six months to one year thereafter, or more frequently as needed if cognitive delays are identified.[ncbi.nlm.nih.gov] facial profile, a long philtrum (Fig 1), hyperplastic alveolar ridges, a small upturned nose, a hypoplastic clitoris, short forearms, absence of the upper lacrimal puncta[jamanetwork.com] ... characterized by craniofacial abnormalities, genital hypoplasia, spinal cord malformations and skeletal dysplasia ... macrocephaly with a flat facial profile, hypertelorism[ibis-birthdefects.org]

    Missing: Wide Space Between the First and Second Toe
  • Waisman Syndrome

    delay, cognitive impairment, macroencephaly, and, in some, seizures; EO parkinsonism with tremor appeared subsequently as the presenting symptom.[ng.neurology.org] […] phenotype in individuals with Down syndrome that includes significant delay in nonverbal cognitive development accompanied by additional, specific deficits in speech, language[onlinelibrary.wiley.com] The symptoms are similar: developmental delays gr oss and fine motor skill delays speech and language delays learning and behavior problems hyperextensible joints anxiety[fragilexfiles.com]

    Missing: Flat Facial Profile Wide Space Between the First and Second Toe
  • Dubowitz Syndrome

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] The feeding difficulties, developmental and cognitive delay, mottled skin, drug-induced long QT syndrome, short stature, microcephaly, small ears, 2–3 cutaneous syndactyly[journals.plos.org] Wide space between first and second toes Wide-spaced big toe Widely spaced 1st-2nd toes Widely spaced first and second toes Widened gap 1st-2nd toes Widened gap first and[rarediseases.info.nih.gov]

    Missing: Flat Facial Profile
  • Early Infantile Epileptic Encephalopathy Type 2

    Patients with a SYNGAP1 mutation have a developmental delay, cognitive regression and some patients have a autism.[molgen.ua.ac.be] developmental delay and intellectual disability.[ncbi.nlm.nih.gov] […] and motor development and often result in a devastating permanent global developmental delay and intellectual disability.[jmg.bmj.com]

    Missing: Flat Facial Profile Wide Space Between the First and Second Toe
  • Early Infantile Epileptic Encephalopathy Type 17

    […] featuring moderate developmental delay associated with complex stereotypies, mainly facial dyskinesia, and mild epilepsy.[genecards.org] Clinical features range from severe motor and cognitive impairment with marked choreoathetosis, self-injurious behavior and epileptic encephalopathy, to a milder phenotype[genecards.org]

    Missing: Flat Facial Profile Wide Space Between the First and Second Toe
  • Trisomy 10p

    spaced, inverted nipples, mild pectus excavatum; and a sandal gap between the first and second toes.[jmg.bmj.com] The last physical examinationwas at 12months of age and a global developmental delay was established.[docslide.fr] facial profile 90 Poor Moro reflex 85 Hypotonia 80 Hyperflexibility of large joints 80 Loose skin on back of neck 80 Slanted palpebral fissures 80 Dysmorphic pelvis on radiographs[aafp.org]