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1,612 Possible Causes for Cognitive Developmental Delay, Generalized Rhythmic Slowing, Spasticity - Hyperreflexia

  • Hyponatremia

    They are primarily central nervous system (CNS) manifestations, such as irritability, restlessness, lethargy, muscular twitching, spasticity and hyperreflexia, all of which[aafp.org]

    Missing: Cognitive Developmental Delay
  • Dementia

    Cognitive Decline in a Young Adult with Pre-Existent Developmental Delay – What the Adult Neurologist Needs to Know Phillipa J.[web.archive.org]

    Missing: Spasticity - Hyperreflexia
  • Autosomal Recessive Spastic Paraplegia Type 20

    The gait is spastic with weakness, hyperreflexia, and extensor plantar responses in the lower limbs. The upper limbs are variably involved and movements are dysmetric.[disorders.eyes.arizona.edu] All the patients presented with short stature and dysarthria, and were delayed in reaching motor and cognitive developmental milestones.[cags.org.ae] […] disorders characterized by varying degrees of lower limb spasticity, pyramidal weakness, hyperreflexia and hypertonic bladder involvement.[medicbind.com]

    Missing: Generalized Rhythmic Slowing
  • Early Infantile Epileptic Encephalopathy Type 2

    Spasticity and hyperreflexia are often present but some newborn infants are hypotonic.[disorders.eyes.arizona.edu] Patients with a SYNGAP1 mutation have a developmental delay, cognitive regression and some patients have a autism.[molgen.ua.ac.be] developmental delay and intellectual disability.[ncbi.nlm.nih.gov]

    Missing: Generalized Rhythmic Slowing
  • Autosomal Recessive Spastic Paraplegia Type 54

    All the affecteds suffered intellectual disability and/or developmental delay, spastic paraplegia, hyperreflexia and foot contractures.[cags.org.ae] The pure form presents isolated pyramidal signs such as spasticity, hyperreflexia, Babinski sign, and motor deficits, which can be associated with sphincter disorder and deep[neurohic.com] , hyperreflexia, extensor plantar responses, and bladder dysfunction).[ng.neurology.org]

    Missing: Generalized Rhythmic Slowing
  • Hydrocephalus

    , hyperreflexia Changes in vital signs resulting from brainstem compression due to herniation Because the fontanelles of infants are still open, the accumulation of CSF can[amboss.com] […] percentile growth chart) Tense fontanelle Setting sun sign : persistent downward deviation of the eyes due to increased ICP in infants and young children Lower extremity spasticity[amboss.com]

    Missing: Cognitive Developmental Delay
  • Early Infantile Epileptic Encephalopathy Type 6

    Generalized seizures were accompanied at the EEG by electrodecremental activity in 16/39 seizures; diffuse rhythmic slowing in 11/39; slow spike-and-wave complexes in 6/39[psiquiatriainfantil.com.br] Disease onset occurs in the first year of life, followed by developmental delay with cognitive and behavioral dysfunction and substantially elevated risk of premature death[ncbi.nlm.nih.gov] delay or cognitive outcome did not differ between both groups.[pediatricneurologybriefs.com]

    Missing: Spasticity - Hyperreflexia
  • Autosomal Recessive Spastic Paraplegia Type 49

    Neurological examination also showed the classic spastic paraplegia symptoms such as proximal weakness of the lower limbs and profound proximal spasticity.[omicsonline.org] […] abnormalities on examination of patients with pure HSP include spasticity, hyperreflexia, and extensor plantar responses, with weakness of a pyramidal distribution in the[jnnp.bmj.com] Diagnosis of SPG is established by the following clinical features 1, 2 : Typical clinical symptoms of spastic gait impairment and neurologic findings of spastic weakness,[centogene.com]

    Missing: Generalized Rhythmic Slowing
  • Beta-Propeller Protein-Associated Neurodegeneration

    Children with PKAN typically manifest gait problems around age 3 and later develop progressive dystonia, dysarthria, rigidity, spasticity, hyperreflexia and extensor toe signs[nbiaalliance.org] Jennifer and Brian Greene’s 3-year-old daughter Madison can’t walk on her own, has never spoken a single word, and has severe cognitive and developmental delays.[losangeles.cbslocal.com] This is followed by the development of spastic quadriparesis and hyperreflexia and ultimately areflexia and a vegetative state by the end of the first decade.[annalsofian.org]

    Missing: Generalized Rhythmic Slowing
  • Autosomal Recessive Spinocerebellar Ataxia 18

    Over half of the cases display pyramidal symptoms, hyperreflexia, and positive Babinski sign with little to no spasticity.[elsevier.es] […] with Opitz/BBB syndrome are also characterized by developmental delay, ataxia, and midline abnormalities, including hypertelorism, cleft lip/palate, esophagolaryngotracheal[ajnr.org] Screening for OPHN1 mutations in a large cohort of boys with cognitive impairment and vermis hypoplasia led to identification of mutations of this gene in 12%. 42 Patients[ajnr.org]

    Missing: Generalized Rhythmic Slowing