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12 Possible Causes for Cognitive Developmental Delay, Hyperactivity, Wide Space Between the First and Second Toe

  • Seckel Syndrome

    Most children with Seckel syndrome are "friendly and pleasant" but "often hyperkinetic (hyperactive) and easily distracted." This disease is genetic.[medicinenet.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Wide space between first and second toes Wide-spaced big toe Widely spaced 1st-2nd toes Widely spaced first and second toes Widened gap 1st-2nd toes Widened gap first and[rarediseases.info.nih.gov]

  • Dubowitz Syndrome

    The feeding difficulties, developmental and cognitive delay, mottled skin, drug-induced long QT syndrome, short stature, microcephaly, small ears, 2–3 cutaneous syndactyly[journals.plos.org] […] disorder Attention deficit Attention deficit disorder Attention deficit-hyperactivity disorder Attention deficits Childhood attention deficit/hyperactivity disorder [ more[rarediseases.info.nih.gov] Characteristic behavior patterns which have not been cited previously are present in our cases; most patients are hyperactive, shy, hate crowds, and like music, rhythm, and[ncbi.nlm.nih.gov]

  • Down Syndrome

    […] variants: or Down's syndrome Definition of Down syndrome : a congenital condition characterized especially by developmental delays, usually mild to moderate impairment in[merriam-webster.com] In more rare cases, Down syndrome patients may be affected with hyperthyroidism, symptoms of which include breathing and sleeping difficulties, and hyperactivity.[symptoma.com] A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org]

  • Atelosteogenesis Type 2

    He had difficulty in walking, mild proximal muscular hypotonia in the lower extremities and hyperactive deep tendon reflexes.[nature.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Developmental delay may be temporal or permanent; for example, in achondroplasia, motor development may be delayed in the first 2 years, due to macrocephaly and ligamentous[musculoskeletalkey.com]

  • Macrocephaly-Developmental Delay Syndrome

    Most boys have attentional problems and hyperactivity.[intellectualdisability.info] space between first and second toes (sandal toes) clinodactyly of the fifth finger All of these are found in individuals without DS.[medicalhomeportal.org] Since the early 2000s, PTEN germline mutation haploinsufficiency has been reported in association with autism, variable cognitive impairment and developmental delay in the[consultqd.clevelandclinic.org]

  • Russell-Silver Syndrome

    Children with RSS have an increased risk for developmental delay (both motor and cognitive) and learning disabilities.[gemssforschools.org] As they get older, these infants/children may have altered behaviour, such as hyperactivity or, conversely, tiredness, as a symptom of their low blood sugar level •Face -[netmums.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Familial Congenital Nasolacrimal Duct Obstruction

    […] hepatitis (1) Zoonoses (2) Mental health care (257) Acute stress disorder (5) Adjustment disorders (1) Aggression (1) Anxiety (9) Anxiety disorders (2) Attention-deficit/hyperactivity[innovations.ahrq.gov] space between first and second toes (sandal toes) clinodactyly of the fifth finger All of these are found in individuals without DS.[medicalhomeportal.org] Developmental delays are common. Infancy and childhood milestones are often delayed. Many patients have cognitive delays and some are mildly retarded.[disorders.eyes.arizona.edu]

  • Cutis Laxa

    Despite delays in developmental milestones and language, affected children are said to be cheerful and outgoing. Neurologic findings Cognitive.[ncbi.nlm.nih.gov] Hyperactivity has also been reported in GO patients (Lisker et al. , 1979).[scielo.br] Other reported osteoarticular features are: a wide space between the first and second toes; talipes equinovarus; metatarsus adductus; genu recurvatum or genu valgum; flat[scielo.br]

  • Trisomy 10p

    The last physical examinationwas at 12months of age and a global developmental delay was established.[docslide.fr] Cryptorchidism Limb defects Clinodactyly Syndactyly Club foot Wide sandal gap Nail dysplasia Anemia Extra / single palmar creases Narrow thorax and pelvis / Ocular malformation Hyperactivity[e-sciencecentral.org] spaced, inverted nipples, mild pectus excavatum; and a sandal gap between the first and second toes.[jmg.bmj.com]

  • Baraitser Syndrome

    The child was found to be hyperactive, hyperkinetic, inattentive, most of the type happy and hyper sociable, being able to go away with complete strangers.[ijpd.in] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Early neurologic impairment is evident including developmental delay, intellectual disability, ataxia, dysarthria, sensorineural hearing loss, myoclonus and seizures.[mendelian.co]

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