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11 Possible Causes for Cognitive Developmental Delay, Malocclusion, Wide Space Between the First and Second Toe

  • Down Syndrome

    Dental malocclusion and macroglossia are associated. Technical modifications to increase macroglossia surgery safety and efficacy have been described.[doi.org] A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org] […] variants: or Down's syndrome Definition of Down syndrome : a congenital condition characterized especially by developmental delays, usually mild to moderate impairment in[merriam-webster.com]

  • Seckel Syndrome

    Dental findings include hypodontia, enamel hypoplasia, crowding, and Class II malocclusion.[ncbi.nlm.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] 0010230 Cryptorchidism Undescended testes Undescended testis [ more ] 0000028 Dental crowding Crowded teeth Dental overcrowding Overcrowding of teeth [ more ] 0000678 Dental malocclusion[rarediseases.info.nih.gov]

  • Dubowitz Syndrome

    Significant clinical correlation includes: smaU stature, microcephaly, abnormal ears, ptosis, hypertelorism, wide nasal bridge, dental malocclusion, eczema, and mental retardation[healio.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] The feeding difficulties, developmental and cognitive delay, mottled skin, drug-induced long QT syndrome, short stature, microcephaly, small ears, 2–3 cutaneous syndactyly[journals.plos.org]

  • Atelosteogenesis Type 2

    Read More Camouflage treatment of skeletal Class III malocclusion in an adult cleft-palate patient using passive self-ligating system.[pubfacts.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Developmental delay may be temporal or permanent; for example, in achondroplasia, motor development may be delayed in the first 2 years, due to macrocephaly and ligamentous[musculoskeletalkey.com]

  • Macrocephaly-Developmental Delay Syndrome

    She also had joints with lax ligaments, a high arched palate, and dental malocclusion (upper front teeth extending over her lower front teeth).[chginc.org] space between first and second toes (sandal toes) clinodactyly of the fifth finger All of these are found in individuals without DS.[medicalhomeportal.org] Since the early 2000s, PTEN germline mutation haploinsufficiency has been reported in association with autism, variable cognitive impairment and developmental delay in the[consultqd.clevelandclinic.org]

  • Russell-Silver Syndrome

    Though orthodontic treatment may be performed for the malocclusion caused by growth disturbance and right - left asymmetry of viscerocranium, cleft palate is rarely complicated[ci.nii.ac.jp] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Children with RSS have an increased risk for developmental delay (both motor and cognitive) and learning disabilities.[gemssforschools.org]

  • Cutis Laxa

    . , 1998), malocclusion, crossbite, dental crowding and diminished height of the alveolar bone (Lustmann et al. , 1993).[scielo.br] Despite delays in developmental milestones and language, affected children are said to be cheerful and outgoing. Neurologic findings Cognitive.[ncbi.nlm.nih.gov] Other reported osteoarticular features are: a wide space between the first and second toes; talipes equinovarus; metatarsus adductus; genu recurvatum or genu valgum; flat[scielo.br]

  • Familial Congenital Nasolacrimal Duct Obstruction

    Nonophthalmic findings in Crouzon syndrome include crowding of the maxillary teeth, lateral palatal swellings, and jaw malocclusion secondary to maxillary hypoplasia. 16 Of[entokey.com] space between first and second toes (sandal toes) clinodactyly of the fifth finger All of these are found in individuals without DS.[medicalhomeportal.org] Developmental delays are common. Infancy and childhood milestones are often delayed. Many patients have cognitive delays and some are mildly retarded.[disorders.eyes.arizona.edu]

  • Genee-Wiedemann Syndrome

    A case of Angle Class II malocclusion with dental crowding in a growing patient.[reins.tmd.ac.jp] He had a wide space between the first and second toe of his feet and subungual fibroma on the second and third toe of the right foot and on the third toe of the left foot.[jmg.bmj.com] Estimates have been made for individuals with specific clinical presentations such as developmental delay/cognitive disability and autism spectrum disorders; in these phenotypes[nature.com]

  • Baraitser Syndrome

    […] amenorrhea Hand polydactyly Ventricular hypertrophy Abnormal palate morphology Pancytopenia Low posterior hairline Bone marrow hypocellularity Amenorrhea Retinal dysplasia Dental malocclusion[mendelian.co] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Early neurologic impairment is evident including developmental delay, intellectual disability, ataxia, dysarthria, sensorineural hearing loss, myoclonus and seizures.[mendelian.co]

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