Create issue ticket

1,299 Possible Causes for Cognitive Developmental Delay, Thin Brain Stem, Wide Space Between the First and Second Toe

  • Seckel Syndrome

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Wide space between first and second toes Wide-spaced big toe Widely spaced 1st-2nd toes Widely spaced first and second toes Widened gap 1st-2nd toes Widened gap first and[rarediseases.info.nih.gov] Wide space between first and second toes Widely spaced 1st-2nd toes Widely spaced first and second toes Widened gap 1st-2nd toes Widened gap first and second toe [ more ][rarediseases.info.nih.gov]

  • Waisman Syndrome

    The cervical spinal cord was already thin at the first observation. 17 In patient 3, brain stem atrophy and WM abnormalities progressed for 7 years.[ajnr.org] delay, cognitive impairment, macroencephaly, and, in some, seizures; EO parkinsonism with tremor appeared subsequently as the presenting symptom.[ng.neurology.org] […] phenotype in individuals with Down syndrome that includes significant delay in nonverbal cognitive development accompanied by additional, specific deficits in speech, language[onlinelibrary.wiley.com]

    Missing: Wide Space Between the First and Second Toe
  • Autosomal Recessive Spinocerebellar Ataxia 18

    B, Midline sagittal T2 image demonstrates an atrophic vermis but normal volume of the brain stem.[ajnr.org] […] with Opitz/BBB syndrome are also characterized by developmental delay, ataxia, and midline abnormalities, including hypertelorism, cleft lip/palate, esophagolaryngotracheal[ajnr.org] Typical MR imaging findings in these patients are abnormal size or morphology of the brain stem or cerebellum.[ajnr.org]

    Missing: Wide Space Between the First and Second Toe
  • Helsmoortel-van der Aa Syndrome

    Cerebellar peduncles & Brain stem Spinal cord: Corticospinal tracts & Dorsal columns NCV: Normal Progressive Spastic Ataxia & Hypomyelinating Leukodystrophy (SPAX8) 117 NK6[neuromuscular.wustl.edu] To identify most (if not all) conditions with ID, we searched for entries with either “mental retardation” or “developmental delay”, “intellectual disability”, and “cognitive[f1000research.com] , behavioral problems, or developmental delay.[eyewiki.aao.org]

    Missing: Wide Space Between the First and Second Toe
  • Iron Deficiency

    The latter include decreased aerobic work performance, hair loss, developmental delay, cognitive and intellectual impairment, adverse pregnancy outcome, and impaired immune[www2.gov.bc.ca] Reversal of developmental delays in iron-deficient anaemic infants treated with iron. Lancet 1993;341(8836):1-4. Lozoff B, Jimenez E, Wolf AW.[cdc.gov] Iron deficiency and cognitive function. Annu Rev Nutr 1993;13:521-37. Idjradinata P, Pollitt E.[cdc.gov]

    Missing: Thin Brain Stem Wide Space Between the First and Second Toe
  • Down Syndrome

    A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org] […] variants: or Down's syndrome Definition of Down syndrome : a congenital condition characterized especially by developmental delays, usually mild to moderate impairment in[merriam-webster.com] spacing, often with a deep plantar groove between the first and second toes.[doi.org]

    Missing: Thin Brain Stem
  • Dubowitz Syndrome

    1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] The feeding difficulties, developmental and cognitive delay, mottled skin, drug-induced long QT syndrome, short stature, microcephaly, small ears, 2–3 cutaneous syndactyly[journals.plos.org] Wide space between first and second toes Wide-spaced big toe Widely spaced 1st-2nd toes Widely spaced first and second toes Widened gap 1st-2nd toes Widened gap first and[rarediseases.info.nih.gov]

    Missing: Thin Brain Stem
  • Early Infantile Epileptic Encephalopathy Type 2

    Patients with a SYNGAP1 mutation have a developmental delay, cognitive regression and some patients have a autism.[molgen.ua.ac.be] developmental delay and intellectual disability.[ncbi.nlm.nih.gov] […] and motor development and often result in a devastating permanent global developmental delay and intellectual disability.[jmg.bmj.com]

    Missing: Thin Brain Stem Wide Space Between the First and Second Toe
  • Early Infantile Epileptic Encephalopathy Type 17

    […] featuring moderate developmental delay associated with complex stereotypies, mainly facial dyskinesia, and mild epilepsy.[genecards.org] Clinical features range from severe motor and cognitive impairment with marked choreoathetosis, self-injurious behavior and epileptic encephalopathy, to a milder phenotype[genecards.org]

    Missing: Thin Brain Stem Wide Space Between the First and Second Toe
  • Early Infantile Epileptic Encephalopathy Type 6

    Disease onset occurs in the first year of life, followed by developmental delay with cognitive and behavioral dysfunction and substantially elevated risk of premature death[ncbi.nlm.nih.gov] delay or cognitive outcome did not differ between both groups.[pediatricneurologybriefs.com] delay, or cognitive outcome.[ncbi.nlm.nih.gov]

    Missing: Thin Brain Stem Wide Space Between the First and Second Toe