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47 Possible Causes for Colonic Perforation, Delayed Wound Healing, Easy Bruising

  • Ehlers Danlos Syndrome

    bruising, arterial, intestinal, and/or uterine fragility.[ncbi.nlm.nih.gov] wound healing.[symptoma.com] He had a history of colon perforation.[ncbi.nlm.nih.gov]

  • Ehlers-Danlos Syndrome Type 4

    bruising, bruising without trauma, and fragile arteries, intestine, and/or uterus.[diseaseinfosearch.org] The oral manifestations include increased mucosal fragility, delayed wound healing, early onset generalized periodontitis and temporomandibular joint hypermobility.[jdrr.org] Only 14 cases of spontaneous colonic perforation have been reported in the literature, but only two in children 1 , 2 Skin and joint manifestations are less prominent than[academic.oup.com]

  • Malabsorption Syndrome

    bruising; tingling in fingers or toes; and numbness or burning sensation in legs or feet.[encyclopedia.com] Possible complications of ulcerative colitis include:  Severe bleeding  A hole in the colon (perforated colon)  Severe dehydration  Liver disease (rare)  Kidney stones[slideshare.net] […] and unusually malodorous Excessive gas Abdominal discomfort or cramps, especially after eating Fatigue Weight loss or emaciation Night blindness (vitamin A malabsorption) Easy[healthcommunities.com]

  • Dexamethasone

    bruising, anxiety, or depression.[rxlist.com] wound healing Withdraw therapy with gradual tapering dose May have systemic and local effects; examine joint fluid, as necessary to exclude a septic process; avoid injection[reference.medscape.com] (see section 4.4 Special warnings and precautions for use) Intestinal perforation Corticosteroids can be associated with an increased risk of colonic perforation in severe[medicines.org.uk]

  • Ehlers-Danlos Syndrome due to Tenascin-X Deficiency

    bruising without atrophic scarring.[orpha.net] These patients lack atrophic scars—a major diagnostic criteria for classic Ehlers-Danlos syndrome (EDS); delayed wound healing, a feature of classic EDS, is only present in[medical-dictionary.thefreedictionary.com] There is a high risk of recurrent colonic perforations. Pregnancy increases the likelihood of a uterine or vascular rupture.[ojrd.biomedcentral.com]

  • Rectal Obstruction

    bruising, spontaneously resolving dislocations of joints, scoliosis and ocular features such as keratoconus depending on the type of EDS.1-8 Multiple hernias are usually[tropicalgastro.com] Colon perforation occurred in 2 patients, who underwent emergency surgery. Ten (62.5%) of group A and 1 (7.1%) of group B complained of pain (P .011).[ncbi.nlm.nih.gov] Free intraperitoneal gas indicates colonic perforation.[surgwiki.com]

  • Ehlers Danlos Syndrome Classic Type

    bruising, and generalized joint hypermobility.[ncbi.nlm.nih.gov] There is a high risk of recurrent colonic perforations. Pregnancy increases the likelihood of a uterine or vascular rupture.[ojrd.biomedcentral.com] wound healing with formation of atrophic scars, easy bruising, and generalized joint hypermobility.[invisibleillnessforum.com]

  • Connective Tissue Disorder due to Lysyl Hydroxylase-3 Deficiency

    bruising and propensity to develop ecchymoses (bruising without trauma).[snpedia.com] The oral manifestations include increased mucosal fragility, delayed wound healing, early onset generalized periodontitis and temporomandibular joint hypermobility.[jdrr.org] A case with colonic perforation in a young girl, with a fatal outcome, was related to a novel mutation of the COL3A1 gene.[emedicine.medscape.com]

  • Ehlers-Danlos Syndrome Type 2

    bruising * Mitral valve prolapse * Tricuspid valve prolapse * Aortic root dilatation * Sinus of valsalva dilatation Causes - Ehlers-Danlos syndrome type 2 Not supplied.[checkorphan.org] Case report A 12-year-old girl presented to the Department of Dermatology at The Cleveland Clinic Foundation in January 1982, with a history of delayed wound healing, easy[mdedge.com] In a retrospective review of the literature, 41 colonic perforations were reported, 80% of which were in the sigmoid colon.[karger.com]

  • Ehlers-Danlos Syndrome, Type 7

    In retrospect, this child had several major criteria of EDS: 4 history of spontaneous colonic perforation, easy bruising, characteristic face, keloid on the chin and forehead[academic.oup.com] The oral manifestations include increased mucosal fragility, delayed wound healing, early onset generalized periodontitis and temporomandibular joint hypermobility.[jdrr.org] wound healing with atrophic scarring. [3] People with lax joints and multiple scars were first described in the medical writings of Hippocrates, dating back to 400 BCE. [[emedicine.medscape.com]

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