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39 Possible Causes for Colonic Perforation, Delayed Wound Healing, Easy Bruising

  • Ehlers-Danlos Syndrome Type 4

    bruising, bruising without trauma, and fragile arteries, intestine, and/or uterus.[diseaseinfosearch.org] The oral manifestations include increased mucosal fragility, delayed wound healing, early onset generalized periodontitis and temporomandibular joint hypermobility.[jdrr.org] Only 14 cases of spontaneous colonic perforation have been reported in the literature, but only two in children 1, 2 Skin and joint manifestations are less prominent than[academic.oup.com]

  • Ehlers Danlos Syndrome

    Skin hyperextensibility, easy bruising, tissue fragility, atrophic scars, loss of muscle tone, Kyphoscoliosis, and osteopenia (bones which are less dense than normal) are[rarediseases.about.com] wound healing.[symptoma.com] Enhanced computed tomography revealed diverticula and perforation in the sigmoid colon.[ncbi.nlm.nih.gov]

  • Ehlers-Danlos Syndrome Type 2

    bruising * Mitral valve prolapse * Tricuspid valve prolapse * Aortic root dilatation * Sinus of valsalva dilatation Causes - Ehlers-Danlos syndrome type 2 Not supplied.[checkorphan.org] Case report A 12-year-old girl presented to the Department of Dermatology at The Cleveland Clinic Foundation in January 1982, with a history of delayed wound healing, easy[mdedge.com] In a retrospective review of the literature, 41 colonic perforations were reported, 80% of which were in the sigmoid colon.[karger.com]

  • Ehlers-Danlos Syndrome due to Tenascin-X Deficiency

    These patients lack atrophic scars—a major diagnostic criteria for classic Ehlers-Danlos syndrome (EDS); delayed wound healing, a feature of classic EDS, is only present in[medical-dictionary.thefreedictionary.com] bruising without atrophic scarring.[orpha.net] There is a high risk of recurrent colonic perforations. Pregnancy increases the likelihood of a uterine or vascular rupture.[syndrome.medicclub.info]

  • Rheumatoid Arthritis

    Steroids do have side effects, such as easy bruising, bone thinning, cataracts, and diabetes. Anti-rheumatic medicines can help treat RA.[familydoctor.org] Masahiro Tada, Kentaro Inui, Yuko Sugioka, Kenji Mamoto, Tadashi Okano, Takuya Kinoshita, Noriaki Hidaka and Tatsuya Koike, Delayed wound healing and postoperative surgical[doi.org] The patient who received only high dose corticosteroid developed massive colon perforation as well as acute renal insufficiency a few days after her ocular event.[ncbi.nlm.nih.gov]

  • Ehlers-Danlos-Syndrome Type 10

    […] susceptibility Bruise easily Easy bruisability Easy bruising [ more ] 0000978 Hyperextensible skin Hyperelastic skin Skin hyperelasticity Stretchable skin [ more ] 0000974[rarediseases.info.nih.gov] wound healing.[metro.co.uk] He had a spontaneous colonic perforation at the age of 16 years, followed 3 years later by sudden development of bilateral renal infarctions and hypertension, which on angiography[jrheum.org]

  • Cushing Syndrome

    Decreased IL-2 levels prevent the proliferation of T-lymphocytes. [9] History and Physical Patients may have a history of weight gain, fatigue, weakness, delayed wound healing[ncbi.nlm.nih.gov] bruising, hirsutism, and progressive muscle weakness.[ncbi.nlm.nih.gov] We describe six patients with endogenous Cushing syndrome (CS) who developed sudden perforation of colonic diverticula necessitating urgent exploratory laparotomy.[ncbi.nlm.nih.gov]

  • Dermatosparaxis

    The ability of wound healing is delayed and after successful primary healing the stretching of scars is typical for all EDS types.[p-eds.org] The most consistent anomalies during the first years of life are premature rupture of the membranes, extreme skin fragility and easy bruising, large fontanels, blue sclerae[ncbi.nlm.nih.gov] Spontaneous sigmoid colon perforation in the absence of known diverticular disease or other bowel pathology; 4.[raredr.com]

  • Ehlers-Danlos Syndrome, Type 3

    wound healing Kyphoscoliotic EDS Kyphoscoliotic EDS (kEDS) is rare.[nhs.uk] Signs of Ehlers-Danlos syndromes include easy bruising without significant trauma and joints that can move beyond the normal range of motion.[medicinenet.com] The most common causes of death are from a rupture of the aorta, colon perforation, or cerebral bleeding.[morphopedics.wikidot.com]

  • Rectal Obstruction

    An earlier episode of delayed wound healing as well as large hernia could also be explained now.[tropicalgastro.com] […] radiological evidence of colonic perforation or peritonitis.[nice.org.uk] Colon perforation occurred in 2 patients, who underwent emergency surgery. Ten (62.5%) of group A and 1 (7.1%) of group B complained of pain (P .011).[ncbi.nlm.nih.gov]

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