Complete Blood Count Abnormal & Delayed Growth and Development & Night Blindness: Causes & Reasons

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Patient File

Sex unknown, Age unknown

Reported Symptoms

Complete Blood Count Abnormal, Delayed Growth and Development, Night Blindness,

Negated

None

Unsure

None

Possible Causes

Vitamin A Deficiency

It may also lead to infections, gastroenteritis, delayed growth, and bone development. (Pregnancy Diet: Should You Really Eat For Two?) How Much Vitamin A Do You Need? [food.ndtv.com]

She presented at 33 weeks of pregnancy with night blindness as a result of vitamin A deficiency. [ncbi.nlm.nih.gov]

Vitamin A deficiency and resulting night blindness have previously been reported in patients with chronic liver disease before undergoing liver transplantation. [ncbi.nlm.nih.gov]

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Myxedema

Poor growth, resulting in short stature Delayed development of permanent teeth Delayed puberty Poor mental development When to see a doctor See your doctor if you're feeling [mayoclinic.org]

Hypothyroidism in children and teens In general, children and teens who develop hypothyroidism have the same signs and symptoms as adults do, but they may also experience: [mayoclinic.org]

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Malabsorption Syndrome

[…] over time as a result of chronic malabsorption: Anemia Delayed growth and development in children Difficulty concentrating, confusion, and sometimes personality changes Malnutrition [labtestsonline.org]

Impaired absorption of vitamin A could result in poor vision and night blindness as well as dermatitis. [web.archive.org]

Inflammation of mouth (stomatitis) Easy bruising, bleeding gums Numbness and tingling in feet and hands Paleness Muscle or bone pain The following are some complications that can develop [labtestsonline.org]

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Spleen Disease

Tests A complete blood count (CBC) often shows abnormal blood cell counts. [mpnresearchfoundation.org]

Children and adolescents with Gaucher disease may experience a delay in growth and development. [cerezyme.com]

Derangement in the complete blood (cell) counts and morphology including WBC, RBC, and platelets will vary based on underlying disease state. [ncbi.nlm.nih.gov]

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Tropical Sprue

In children, sprue leads to: Delay in the maturing of bones (skeletal maturation) Growth failure Call your health care provider if: Tropical sprue symptoms get worse or do [medlineplus.gov]

People with this disorder may also experience a profound loss of appetite (anorexia), a sore tongue, night blindness, weight loss, a loss of strength and energy (asthenia) [rarediseases.org]

You develop new symptoms. You have diarrhea or other symptoms of this disorder for a long period of time, especially after spending time in the tropics. [medlineplus.gov]

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Zinc Deficiency

Her complete blood cell count with differential was normal, ferritin concentration level was 110 ng/mL (reference, 40-200 ng/mL), iron level was 75 microg/dL (reference, 35 [ncbi.nlm.nih.gov]

Individuals with zinc deficiency present with the following signs and symptoms: Delayed growth and development Fertility issues Diarrhea Unexplained weight loss Loss of appetite [symptoma.com]

In children or adults, manifestations also include alopecia, impaired immunity, anorexia, dermatitis, night blindness, anemia, lethargy, and impaired wound healing. [msdmanuals.com]

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Vitamin Deficiency

This is followed by delayed development, with deceleration of head growth, hypotonia, and ataxia, followed in one‐third of children by dyskinesias (choreo‐athetosis, hemiballismus [doi.org]

It is manifested with reduced night vision, night blindness, and xerophthalmia. [icd9data.com]

Implications of Vitamin A Deficiency Night blindness is one of the first signs of vitamin A deficiency. [adoptionnutrition.org]

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Cooley's Anemia

Blood tests Peripheral blood smear shows small, abnormally-shaped red blood cells Complete blood count shows anemia Haemoglobin electrophoresis shows abnormal hemoglobin Prognosis [myvmc.com]

Some of the most common ones include: bone deformities, especially in the face dark urine delayed growth and development excessive tiredness and fatigue yellow or pale skin [healthline.com]

Colour and night blindness can occur. These complications may be reversible. [patient.info]

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MELAS Syndrome

Complete blood count, electrolyte levels, liver function tests, blood urea nitrogen, and creatinine levels were all normal. Serum glucose was elevated. [stroke.ahajournals.org]

blindness. [journals.lww.com]

Patients may have visual complaints due to ophthalmoplegia, and they may experience blindness due to optic atrophy and difficulties with night vision due to pigmentary retinopathy [markalewis.com]

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Cystic Fibrosis

Inadequate absorption of the fat-soluble vitamins A, D, E, and K may lead to night blindness, osteopenia (decrease in bone density), osteoporosis, anemia, and bleeding disorders [msdmanuals.com]

[…] to the results until completion of the third night ( Gozal 1997 ). [doi.org]

[…] that while participants were aware of the intervention being administered; all were reportedly unaware of the purpose of the trial with participants and sleep technicians blinded [doi.org]

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Thalassemia

A complete blood count (CBC) reveals anemia. A test called hemoglobin electrophoresis shows the presence of an abnormal form of hemoglobin. [nlm.nih.gov]

growth and development, tiredness, bone problems such as osteoporesis or enlarged spleen and liver. [columbiadoctors.org]

Colour and night blindness can occur. These complications may be reversible. [patient.info]

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Porphyria

Symptoms of porencephaly include delayed growth and development, spastic hemiplegia (slight or incomplete paralysis), hypotonia (low muscle tone), seizures (often infantile [ninds.nih.gov]

blindness in Refsum disease, [7] and photosensitive dermatitis in porphyrias (rare in acute intermittent porphyria). [emedicine.medscape.com]

Signs may include delayed growth and development, spastic paresis (slight or incomplete paralysis ), hypotonia (decreased muscle tone), seizures (often infantile spasms ), [medicinenet.com]

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Ulcerative Colitis

Complete blood cell count and blood chemistries may be ordered, looking for anemia (low red blood cell count) and other abnormalities, including those from dehydration. [doi.org]

Among younger children, ulcerative colitis may delay growth and development. [crohnscolitisfoundation.org]

(n 19) or oral 5‐ASA 0.5 g three times per day (n 19) for two years in an investigator‐blind trial. [doi.org]

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Alpha-Thalassemia

A complete blood count (CBC) reveals anemia. A test called hemoglobin electrophoresis shows the presence of an abnormal form of hemoglobin. [medlineplus.gov]

Children with hemoglobin H disease may have delayed growth and development. Complications from the treatment of hemoglobin H disease may occur. [stlouischildrens.org]

blindness, type 1A CACNA1FCongenital stationary night blindness, type 2A CACNA1FCongenital stationary night blindness, type 2A, severe HDAC8Cornelia de Lange syndrome 5 L1CAMCorpus [invictagenetics.pl]

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Thalassemia Minor

A complete blood count (CBC) reveals anemia. A test called hemoglobin electrophoresis shows the presence of an abnormal form of hemoglobin. [nlm.nih.gov]

Some of the most common ones include: bone deformities, especially in the face dark urine delayed growth and development excessive tiredness and fatigue yellow or pale skin [healthline.com]

Colour and night blindness can occur. These complications may be reversible. [patient.info]

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Celiac Disease

These cases consisted of subjects presenting with various GIS symptoms and indicated for endoscopy (with chronic diarrhea, delayed growth and development, abdominal pains, [ncbi.nlm.nih.gov]

[…] folate deficiency) Growth failure in children Bone pain (osteoporosis and osteopenia, vitamin D and calcium deficiency) Muscle cramps (magnesium and calcium deficiency) Night [ojrd.com]

In children, untreated celiac disease can cause stunted growth, delayed development and behavioral issues. For women, untreated celiac disease can lead to infertility. [livescience.com]

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Hypocupremia

Testosterone treatment in adolescent boys with constitutional delay in growth and development. N. Engl. J. Med. 319, 1563–1567 (1988). 141. Spratt, D. I. et al. [nature.com]

blindness Seizures Storage liver disease Infant feeding problems Liver storage disease Note that Mental retardation - hypocupremia - hypobetalipoproteinemia symptoms usually [checkorphan.org]

Symptoms and Signs of Vitamin and Mineral Deficiency and Toxicity Nutrient Signs and Symptoms of Deficiency Signs and Symptoms of Toxicity Vitamin A (Retinol) Night blindness [emedicinehealth.com]

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Acquired Immunodeficiency Syndrome

For patients receiving ganciclovir or foscarnet, monitoring of complete blood counts and serum electrolytes and renal function should be performed twice weekly during induction [cdc.gov]

Children with hemoglobin H disease may have delayed growth and development. Complications from the treatment of hemoglobin H disease may occur. [stanfordchildrens.org]

blindness. [doi.org]

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Pulmonary Tuberculosis

growth of M. tuberculosis in culture media. [nature.com]

blindness. [dovepress.com]

Patients who had the diagnosis established by sputum cultures (patient Nos 1, 5, 6 and 7) had a median delay of 25 days (range 20–40) in anti-TB treatment due to the slow [nature.com]

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Hepatoerythropoietic Porphyria

Infertility Growth hormone deficiency Oligohydramnios Small hand Amenorrhea Stroke Sleep disturbance Full cheeks Tapered finger Feeding difficulties Downturned corners of [mendelian.co]

blindness in Refsum disease, [7] and photosensitive dermatitis in porphyrias (rare in acute intermittent porphyria). [emedicine.medscape.com]

[…] speech and language development Hemolytic anemia Spontaneous abortion Short foot Gastrointestinal hemorrhage Leukemia Specific learning disability Esotropia Febrile seizures [mendelian.co]

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Anemia due to Vitamin B6 Deficiency

Growth retardation or delayed growth in children with haemolytic anemias. Further Reading What is Anemia? Anemia Causes Anemia Diagnosis Anemia Treatments [news-medical.net]

Therefore, one of the first symptoms of vitamin A deficiency is night blindness. [progressivehealth.com]

Ocular manifestations of vitamin A deficiency include xerophthalmia (dry eyes), keratomalacia (corneal necrosis/ulceration), nyctalopia (night blindness), Bitot’s spots (conjunctival [podiatrytoday.com]

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Malnutrition

Diagnosis Initial diagnostic laboratory studies include the following: Complete blood count Sedimentation rate Serum electrolytes Urinalysis Culture Stool specimens should [emedicine.com]

All of these things, delays in growth, delays in development, and an increase in the number and the severity of diseases experienced by the child; all of these things are [khanacademy.org]

The ocular manifestations of xerophthalmia include conjunctival and corneal xerosis (drying), keratomalacia (corneal necrosis/ulceration), nyctalopia (night blindness), and [ncbi.nlm.nih.gov]

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Kwashiorkor

Development is delayed due to lack of the nutrients and protein essential for optimum brain growth. [health24.com]

Vitamin A deficiency can have ocular effects, causing night blindness among other problems; vitamin D deficiency can have bony effects; vitamin E deficiency can cause neuropathy [emedicine.medscape.com]

It is also delayed because malnourished children have less energy to play and explore their environment. [health24.com]

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Deficiency Disorder

Blood tests, including a complete blood count (CBC), are done. [merckmanuals.com]

Iron deficiency at critical times of growth and development can result in premature births, low birth weight babies, delayed growth and development, delayed normal infant [irondisorders.org]

Xerophthalmia or Night Blindness: Xerophthalmia or night blindness is characterized by blindness due to the poor growth, dryness and keratinisation of epithelial tissue or [stylecraze.com]

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Seckel Syndrome

On laboratory examinations, results of complete blood count and biochemistry panel were normal except low ionized calcium levels (3.87 mg/dl, normal: 4.64–5.28 mg/dl). [termedia.pl]

The prognosis depends on the defects presented, but for the delay in growth and impaired mental development, is considered poor. [medigraphic.com]

Blindness - See Keratomalacia Night blindness-skeletal anomalies-dysmorphism syndrome Nightcliff gardener's disease - See Melioidosis Nigrospinodentatal degeneration - See [rarediseases.info.nih.gov]

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Abetalipoproteinemia

blood count) that shows abnormally shaped red blood cells (thorny appearance) Cholesterol studies, including total cholesterol that shows low levels of VLDL and LDL Stool [medical-dictionary-search-engines.com]

[…] and development. [geneticdiseasefoundation.org]

The patient notes night blindness and, if the condition is untreated, eventually demonstrates loss of foveal function and diffuse drusenlike spots similar to those in retinitis [aao.org]

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Secondary Malnutrition

Diagnosis Initial diagnostic laboratory studies include the following: Complete blood count Sedimentation rate Serum electrolytes Urinalysis Culture Stool specimens should [emedicine.medscape.com]

Children with primary nutritional deficiency can develop a condition called marasmus, characterized by a thin body and stunted growth. [livestrong.com]

This can lead to deficiencies such as scurvy, Beri Beri and night blindness. [ic.steadyhealth.com]

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Beta Thalassemia

A complete blood count (CBC) reveals anemia. A test called hemoglobin electrophoresis shows the presence of an abnormal form of hemoglobin. [medlineplus.gov]

The complications include: Delayed growth and development, including sexual development Heart, liver and spleen problems Endocrine system problems (for example, diabetes or [childrensnational.org]

Colour and night blindness can occur. These complications may be reversible. [patient.info]

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Familial Infantile Myoclonic Epilepsy

Her laboratory tests including a complete blood count, blood chemistries including glucose and toxicology screen were normal. [ncbi.nlm.nih.gov]

[…] in preterm infants linked with delayed cognitive development Image: PD 2012-2014 2minutemedicine.com. [2minutemedicine.com]

A history of night blindness was systematically sought7 but was absent. [jamanetwork.com]

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Autosomal Recessive Congenital Cataract 5

Laboratory investigations including complete blood counts were within normal limits. [e-ijd.org]

These techniques may at least delay the need for surgery until a point when eye growth has stabilized and an IOL can be implanted with less refractive uncertainty. [eyewiki.aao.org]

Dark adaptometry is useful in patients complaining of night blindness (nyctalopia) - which is commonly a feature of these disorders. [patient.info]

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