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126 Possible Causes for Complete Blood Count Abnormal, Progressive Polyneuropathy

  • Vitamin B12 Deficiency

    When you have an abnormal complete blood count (CBC) with a blood smear showing large red blood cells (macrocytosis) or abnormal (hypersegmented) neutrophils ; when you have[] peripheral neuropathy, and spinal degeneration.[] […] normal One-Carbon metabolism leading to the observed clinical neurological manifestations such as nerve damage and, demyelination, degeneration of PNS leading to paralysis, progressive[]

  • Chronic Alcoholism

    The concept of "structural plasticity" has emerged as a potential mechanism in neurodegenerative and psychiatric diseases such as drug abuse, depression, and dementia. Chronic alcoholism is a progressive neurodegenerative disease while the person continues to abuse alcohol, though clinical and imaging studies show[…][]

  • Diabetes Mellitus

    Also called: Diabetes mellitus, DM Summary Diabetes is a disease in which your blood glucose, or blood sugar, levels are too high. Glucose comes from the foods you eat. Insulin is a hormone that helps the glucose get into your cells to give them energy. With type 1 diabetes, your body does not make insulin. With type 2[…][]

  • Vasculitis

    The following blood and urine tests are usually done: Complete blood count : Abnormalities, such as lower counts of red blood cells (anemia), too many platelets, too many[] Neuropathy Sensory or Sensory-Motor General patterns Mononeuritis multiplex (13%) Asymmetric polyneuropathy (85%) Distal symmetric polyneuropathy (2%) More slowly progressive[] Blood tests and urine tests, including the following, are usually done: A complete blood cell count is done.[]

  • Multiple Myeloma

    A complete blood count, peripheral blood smear, chemistry screen including calcium and creatinine determinations, β 2 -microglobulin (β 2 M), lactate dehydrogenase and routine[] […] to multiple myeloma The initial presentation occasionally is a polyneuropathy when it is part of a POEMS syndrome (mostly the sclerotic form).[] Patient management Serum protein electrophoresis, complete blood count, measurement of calcium and creatinine values and 24-h urine collection for electrophoresis and immunofixation[]

  • Pernicious Anemia

    Often, anemia caused by chronic diseases goes undetected until a routine test such as a complete blood count (CBC) reveals abnormal results.[] Laboratory Tests The initial test for anemia, the complete blood count (CBC) , may reveal many abnormal results. Hemoglobin and/or hematocrit may be low.[] Even in patients with a normal complete blood cell count, it may be worthwhile to monitor the MCV after treatment because a significant decline within the normal range provides[]

  • Waldenstrom Macroglobulinemia

    Blood tests may be done to check the CBC (complete blood count). Protein electrophoresis can be used to detect increased levels of immunoglobulin M (IgM).[] Neuropathy is typically slowly progressive, distal, symmetrical, and sensorimotor.[] Complete blood count demonstrated platelets 3 x10 9 /l. Immature platelet fractionation was elevated at 18.3%. Examination of the blood film revealed no abnormalities.[]

  • Thiamine Deficiency

    For all 33 patients, complete blood counts and blood chemistries processed on admission were normal. Some cases had evidence of hepatic and renal abnormalities.[] Nerve conduction studies were consistent with axonal, length-dependent polyneuropathy.[] This patient illustrates that eating disorders can be an uncommon cause of rapidly progressive paresthesias, weakness, and neurological decline due to thiamine deficiency.[]

  • Amyloidosis

    Tafamidis is a TTR stabilizer that is orally administered and, by interfering with amyloid fibril formation and deposition, is capable of slowing progression of TTR polyneuropathy[] Specifically, hereditary ATTR amyloidosis with polyneuropathy (hATTR-PN), also referred to as familial amyloidotic polyneuropathy (FAP) is an inherited, progressive, life-threatening[] Oral tafamidis therapy has inhibited the progression of neurological and cardiovascular symptoms this far.[]

  • Subacute Combined Degeneration of Spinal Cord

    Blood tests that may be ordered include: Complete blood count (CBC) Vitamin B12 blood level Methylmalonic acid blood level Vitamin B12 is given, usually by injection into[] Blood tests, including a complete blood count (CBC), vitamin B12 blood level, or methylmalonic acid blood level are used to diagnose anemia or vitamin B12 deficiency.[] There may also be abnormal pupil responses, loss of sharp vision, and other changes.[]

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