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55 Possible Causes for Congenital Bleeding Diathesis, Mild Thrombocytopenia

  • Bernard-Soulier Syndrome

    thrombocytopenia, large platelets and failure of platelet aggregation with ristocetin.[ncbi.nlm.nih.gov] His father and paternal grandmother showed a mild thrombocytopenia (108 x 10(9)/L and 120 x 10(9)/L platelets respectively) while mothers and sister's referred normal platelet[ncbi.nlm.nih.gov] Bernard Soulier syndrome: Presentation: Mucosal and increased skin bleeding Differentiating factor: presents in the same fashion as vWF EXCEPT for three features: a mild thrombocytopenia[usmleforum.com]

  • Thrombocytopenia

    thrombocytopenia (81-120 103/μL), or normal-increased platelet count ( 120 103/μL).[ncbi.nlm.nih.gov] […] anomalies Varies depending on primary abnormality Often asymptomatic when there is no bleeding diathesis Disseminated intravascular coagulation Severe Acute illness; bleeding[aafp.org] Mild thrombocytopenia may require no treatment at all, especially when caused by pregnancy. If caused by pregnancy, it usually goes away after childbirth.[stjude.org]

  • Oculootoradial Syndrome

    Some affected individuals have been reported to have mild thrombocytopenia, leukocytosis, shoulder girdle hypoplasia, cardiac involvement, kidney malrotation, intermediate[malacards.org] Björnstad syndrome BJHS Blackfan-Diamond anemia Bladder exstrophy Blau syndrome BLC Bleeding diathesis due to glycoprotein VI deficiency Bleeding diathesis due to thromboxane[csbg.cnb.csic.es] Other less consistent malformations include heart involvement, mild thrombocytopenia and leukocytosis (before age 50), shoulder girdle hypoplasia, imperforate anus, kidney[malacards.org]

  • Thrombocytopenia Due to Sequestration

    [[Kasabach-Merritt Syndrome]]) Physiology : abnormal vessel wall - damage to RBC Clinical : mild thrombocytopenia Infection : these are characterized by MAHA with thrombocytopenia[mdnxs.com] […] anomalies Varies depending on primary abnormality Often asymptomatic when there is no bleeding diathesis Disseminated intravascular coagulation Severe Acute illness; bleeding[aafp.org] During laboratory examination: large size of platelets - up to 8-12 micron (giant platelets), mild thrombocytopenia, changes in morphology of platelets and neutrophils.[iliveok.com]

  • Platelet-Type Bleeding Disorder 17

    Gray platelet syndrome (GPS) is a predominantly recessive platelet disorder that is characterized by mild thrombocytopenia with large platelets and a paucity of α-granules[ncbi.nlm.nih.gov] Abstract The gray platelet syndrome (GPS) is a rare congenital platelet disorder characterized by mild to moderate bleeding diathesis, macrothrombocytopenia and lack of azurophilic[ncbi.nlm.nih.gov] A 14-year-old boy had bleeding diathesis, mild thrombocytopenia, giant platelets with severe defect of alpha-granule secretory proteins, myelofibrosis and splenomegaly.[ncbi.nlm.nih.gov]

  • Autoimmune Thrombocytopenia

    Mild thrombocytopenia is a common adverse effect of interferon-alpha and pegylated interferon-alpha, largely ascribed to bone marrow suppression.[ncbi.nlm.nih.gov] […] anomalies Varies depending on primary abnormality Often asymptomatic when there is no bleeding diathesis Disseminated intravascular coagulation Severe Acute illness; bleeding[aafp.org] The frequency of thrombocytopenia in neonates born to mother with immune thrombocytopenia is low1. Mild to moderate thrombocytopenia is a common presentation3.[journalijcmes.com]

  • HIV-induced Thrombocytopenia

    Congenital thrombocytopenia Mild to moderate Long history of abnormal platelet count or family history of thrombocytopenia Many disorders associated with giant platelets,[aafp.org] They usually present in the paediatric age group with bleeding diathesis. Mild cases, however, may remain undiagnosed until older age.[racgp.org.au] On the other hand, a patient with mild thrombocytopenia may develop significant bleeding if he/she is on medications like heparin, aspirin or pentoxyfilline.[antimicrobe.org]

  • Bleeding Diathesis

    Clinical laboratory coagulation tests were unimpressive; the only persistent abnormalities include mild thrombocytopenia and moderately reduced Factor V clotting activities[ncbi.nlm.nih.gov] Congenital plasminogen activator inhibitor-1 (PAI-1) deficiency is an extremely rare disorder characterized by a bleeding diathesis that begins in childhood due to hyperfibrinolysis[ncbi.nlm.nih.gov] The main feature gemotologichesky - thrombocytopenia. Sometimes a mild leukocytosis, neutrophilia. Red blood parameters depend on the degree of blood loss.[eurodoctor.ucoz.com]

  • Hemolytic Anemia

    Typically, patients with WAIHA exhibit a mild leukocytosis with neutrophilia but, occasionally, patients present with leucopenia, neutropenia, or thrombocytopenia due to associated[dovepress.com] […] acquired: DIC ( Congenital afibrinogenemia, Purpura fulminans ) - autoimmune ( Antiphospholipid ) Other Essential thrombocytosis - clotting factor: Hemophilia ( A/VIII, B[wikidoc.org] […] anemia, Sideroblastic anemia Blood tests Normocytic - Microcytic - Macrocytic - Normochromic - Hypochromic Other Methemoglobinemia Coagulation / platelets / coagulopathy / bleeding[wikidoc.org]

  • Drug-induced Thrombocytopenia

    Congenital thrombocytopenia Mild to moderate Long history of abnormal platelet count or family history of thrombocytopenia Many disorders associated with giant platelets,[aafp.org] Previously healthy person, mild thrombocytopenia (for example, platelet count 70,000/uL) incidentally discovered on a routine CBC.[oncologynurseadvisor.com] On the other hand, a patient with mild thrombocytopenia may develop significant bleeding if he/she is on medications like heparin, aspirin or pentoxyfilline.[antimicrobe.org]

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