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22 Possible Causes for Congenital Bleeding Diathesis, Myelosuppression

  • Leukoerythroblastic Anemia

    Although thalidomide and lenalidomide can alleviate anemia in myelofibrosis, their use is limited by their respective potential to cause peripheral neuropathy and myelosuppression[askhematologist.com] […] acquired: DIC ( Congenital afibrinogenemia, Purpura fulminans ) - autoimmune ( Antiphospholipid ) Other Essential thrombocytosis - clotting factor: Hemophilia ( A/VIII, B[wikidoc.org] However, lenalidomide was associated with significant myelosuppression.[clevelandclinicmeded.com]

  • Drug-induced Thrombocytopenia

    The origin may be myelosuppression or peripheral, owing to either the consumption of platelets or their immune-mediated destruction.[ncbi.nlm.nih.gov] […] anomalies Varies depending on primary abnormality Often asymptomatic when there is no bleeding diathesis Disseminated intravascular coagulation Severe Acute illness; bleeding[aafp.org] Although rare, mild myelosuppression with trastuzumab has been reported [ 8 ]. To our knowledge, there are only two case reports published of thrombocytopenia [ 9 ].[academic.oup.com]

  • Thrombocytopenia

    […] anomalies Varies depending on primary abnormality Often asymptomatic when there is no bleeding diathesis Disseminated intravascular coagulation Severe Acute illness; bleeding[aafp.org] His treatment is known to be myelosuppressive. This means it reduces the bone marrow activity that creates new blood cells.[chemotherapy.com] IL-11 promotes megakaryocyte maturation, stimulates platelet production, and can enhance hematopoietic recovery following myelosuppression.[tropicalgastro.com]

  • Thrombocytopenia Due to Sequestration

    […] massive splenomegaly spleen contraction stimulated by the sympathetic nervous system can release additional platelets CAUSES Decreased production due to bone marrow failure (myelosuppression[lifeinthefastlane.com] […] anomalies Varies depending on primary abnormality Often asymptomatic when there is no bleeding diathesis Disseminated intravascular coagulation Severe Acute illness; bleeding[aafp.org] , [[Cyclophosphamide]]) Mercaptopurine (6-Mercaptopurine) (see Mercaptopurine, [[Mercaptopurine]]) Methotrexate (see Methotrexate, [[Methotrexate]]) Mild Myelosuppression[mdnxs.com]

  • HIV-induced Thrombocytopenia

    […] occurs when myelosuppressive chemotherapy is used to treat HIV-related non-Hodgkin's lymphoma.[hivinsite.ucsf.edu] […] anomalies Varies depending on primary abnormality Often asymptomatic when there is no bleeding diathesis Disseminated intravascular coagulation Severe Acute illness; bleeding[aafp.org] They usually present in the paediatric age group with bleeding diathesis. Mild cases, however, may remain undiagnosed until older age.[racgp.org.au]

  • Autoimmune Thrombocytopenia

    Myelosuppression is the main toxicity although autoimmune hemolytic anemia (AIHA) is frequently reported.[ncbi.nlm.nih.gov] […] anomalies Varies depending on primary abnormality Often asymptomatic when there is no bleeding diathesis Disseminated intravascular coagulation Severe Acute illness; bleeding[aafp.org] High-dose (HD) cytotoxic therapy may produce remissions but entails risks related to myelosuppression.[ncbi.nlm.nih.gov]

  • Idiopathic Disseminated Cytomegalovirus Infection

    The association of gB types with acute graft versus host disease and death related to myelosuppression has been examined.[emedicine.medscape.com] […] anomalies Varies depending on primary abnormality Often asymptomatic when there is no bleeding diathesis Disseminated intravascular coagulation Severe Acute illness; bleeding[aafp.org] […] treatment should be based on several factors, including the patient's antiretroviral history (treatment naive vs failing therapy) and clinical status (especially underlying myelosuppression[hivinsite.ucsf.edu]

  • Interstitial Nephritis

    There was not any significant myelosuppression and the patient was on regular supplementation with folic acid and vitamin B(12).[ncbi.nlm.nih.gov] . • Oligohydramnios with congenital renal insufficiency may occur in inutero exposure of fetus to NSAIDs which may cause bleeding diathesis, premature closure of ductus arteriosus[slideshare.net]

  • Familial Neutropenia

    During the second half of the 20 th century, this cutoff value was derived from clinical trials which were evaluating the myelosuppressive effects of chemotherapy.[bmchematol.biomedcentral.com] […] acquired: DIC ( Congenital afibrinogenemia, Purpura fulminans ) - autoimmune ( Antiphospholipid ) Other Essential thrombocytosis - clotting factor: Hemophilia ( A/VIII, B[wikidoc.org] […] filgrastim biosimilar, to the reference: a phase III, randomized, double-blind clinical study in the prevention of severe neutropenia in patients with breast cancer receiving myelosuppressive[emedicine.medscape.com]

  • Congenital Neutropenia

    diathesis (Hermansky and Pudlak. 1959.[preventiongenetics.com] […] with nonmyeloid malignancies receiving myelosuppressive anti-cancer drugs associated with a significant incidence of severe neutropenia with fever.[neupogenhcp.com] Myeloid Leukemia - Approval Date 03/30/2015 申請 September 30,2014 適応 for a new indication of use of Neupogen (filgrastim) to increase survival in patients acutely exposed to myelosuppressive[medmk.com]

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