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30 Possible Causes for Congenital Bleeding Diathesis, Partial Thromboplastin Time Increased

  • Bleeding Diathesis

    thromboplastin time was 25 s (reference range, 21–33 s).[] Congenital plasminogen activator inhibitor-1 (PAI-1) deficiency is an extremely rare disorder characterized by a bleeding diathesis that begins in childhood due to hyperfibrinolysis[] bleeding diathesis that begins in childhood due to hyperfibrinolysis as a result of decreased PAI-1 activity.[]

  • Acquired Factor XIII Deficiency

    Factor XIII deficiency should be considered when a patient with excessive bleeding has both normal protime (PT) and activated partial thromboplastin time (aPTT). 6 Congenital[] Abstract Bleeding symptoms are common in healthy children but occasionally may indicate an underlying congenital or acquired bleeding diathesis.[] Congenital factor XIII deficiency, originally recognized by Duckert in 1960, is a rare autosomal recessive disease usually associated with a severe bleeding diathesis with[]

  • Factor XII Deficiency

    thromboplastin time and an increased risk for thromboembolism.[] Definition / general Factor XII deficiency is a congenital disorder that is most commonly inherited as an autosomal recessive trait and is not associated with a bleeding diathesis[] Laboratory analysis shows a markedly increased partial thromboplastin time but normal prothrombin time. Other tests are normal.[]

  • Hereditary Factor I Deficiency

    Background : The inherited dysfibrinogenemias comprise rare congenital coagulation disorders which are clinically characterized by bleeding diathesis and, in occasional patients[] • Serial thrombotic episodes Laboratory abnormalities • Modestly increased prothrombin time in some patients • Shortened or lengthened partial thromboplastin time • Normal[] […] to develop pathological bleeding, thrombosis, or both conditions. [4] Congenital dysfibrinogenemia [ edit ] Presentation [ edit ] Many cases of congenital dysfibrinogenemia[]

  • Purpura Fulminans

    Marked thrombocytopaenia also occurs in this type of infection and as a consequence prothrombin and partial thromboplastin times are increased.[] The hemorrhagic diathesis associated with cyanotic congenital heart disease. In: Lusher JM, Barnhart M, eds. Acquired bleeding disorders in children. Vol. 1.[] […] and activated partial thromboplastin (aPTT) times.[]

  • Factor I Deficiency

    It is frequently associated with bleeding diathesis of varying severity.[] Congenital afibrinogenemia is characterized by the undetectable low level of fibrinogen, which causes hemorrhagic diathesis.[] […] with bleeding diathesis.[]

  • Factor XI Deficiency

    […] activated partial thromboplastin time.[] Deficiency associated with mild bleeding diathesis, but there is poor correlation between activity level and clinical bleeding.[] Laboratory investigations showed an increase in the activated partial thromboplastin time (aPTT) after which he was referred to the hematology polyclinic (104 sec; normal[]

  • Thrombocytopenia

    Prolonged prothrombin time and activated partial thromboplastin time, low fibrinogen, increased D-dimer, thrombocytopenia are all suggestive but not diagnostic.[] […] anomalies Varies depending on primary abnormality Often asymptomatic when there is no bleeding diathesis Disseminated intravascular coagulation Severe Acute illness; bleeding[] […] serum creatinine, blood urea nitrogen, and C-reactive protein (CRP), hyponatremia, and prolonged activated partial thromboplastin time (APPT) and prothrombin time were associated[]

  • Acquired Hemophilia

    However, after prolonged pre-incubation of the plasma, the activated partial thromboplastin time increases again as the inhibitors present in the patient's plasma prevent[] Induce acute and life-threatening hemorrhagic diathesis because of abnormal blood clotting. The person may bleed for no apparent reason.[] Her prothrombin time was normal but her activated partial thromboplastin time was increased to 2.48 (normal range, 0.85-1.17).[]

  • Pulmonary Hypertension

    […] ischemic attack) Bleeding and thrombotic diathesis Hemoptysis Intrapulmonary thrombosis Pulmonary hemorrhage Cerebral bleeding Menorrhagia Epistaxis Hematologic involvement[] , partial thromboplastin time, international normalized ratio): To assess for coagulopathy (increased disease severity) Serum electrolytes (eg, calcium) and glucose levels[] Multiorgan Involvement in Patients With Chronic Cyanotic Congenital Heart Disease and PAH Ischemic and embolic complications Cerebrovascular accidents (stroke or transient[]

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