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67 Possible Causes for Congenital Bleeding Diathesis, Splenomegaly

  • Hemolytic Anemia

    It results in hemolytic anemia and splenomegaly.[icd9data.com] […] acquired: DIC ( Congenital afibrinogenemia, Purpura fulminans ) - autoimmune ( Antiphospholipid ) Other Essential thrombocytosis - clotting factor: Hemophilia ( A/VIII, B[wikidoc.org] […] suffer from a mild hemolytic anemia (Hb levels ranging from 10 to 12.7g/mL) associated with macrocytosis, reticulocytosis, hyperbilirubinemia, hyperferritinemia and slight splenomegaly[ncbi.nlm.nih.gov]

  • Leukoerythroblastic Anemia

    Symptoms and Signs Myeloid metaplasia may result in splenomegaly, particularly in patients with storage diseases.[merckmanuals.com] […] acquired: DIC ( Congenital afibrinogenemia, Purpura fulminans ) - autoimmune ( Antiphospholipid ) Other Essential thrombocytosis - clotting factor: Hemophilia ( A/VIII, B[wikidoc.org] The French authors, Emil-Weil and Clerc, 1 in 1902, and Vaquez and Aubertin, 2 in 1904, first discussed a syndrome characterized by splenomegaly due to myeloid change and[jamanetwork.com]

  • Thrombocytopenia

    We herein describe a case of nephrotic syndrome with thrombocytopenia, lymphadenopathy, systemic inflammation, splenomegaly, kidney enlargement, and progressive renal insufficiency[ncbi.nlm.nih.gov] […] anomalies Varies depending on primary abnormality Often asymptomatic when there is no bleeding diathesis Disseminated intravascular coagulation Severe Acute illness; bleeding[aafp.org] […] intravascular coagulation Mechanical damage of the thrombocytes Artificial heart valves Use of heart-lung machine Dialysis with extracorporeal circulation Diffusion disorders Splenomegaly[flexikon.doccheck.com]

  • Thrombocytopenia Due to Sequestration

    CONSUMERS: Click here for the Consumer Version Increased splenic platelet sequestration can occur in various disorders that cause splenomegaly However, thrombocytopenia that[merckmanuals.com] […] anomalies Varies depending on primary abnormality Often asymptomatic when there is no bleeding diathesis Disseminated intravascular coagulation Severe Acute illness; bleeding[aafp.org] […] and MODS, sequestration also occurs in sepsis through binding to endothelium the spleen normally sequesters 1/3 of the body’s platelets, this increases to 90% in massive splenomegaly[lifeinthefastlane.com]

  • Acquired Hemolytic Anemia

    Clinical features - splenomegaly 4.[slideplayer.com] […] acquired: DIC ( Congenital afibrinogenemia, Purpura fulminans ) - autoimmune ( Antiphospholipid ) Other Essential thrombocytosis - clotting factor: Hemophilia ( A/VIII, B[wikidoc.org] Splenomegaly. Venous thrombosis occasionally. 15. Severe form. There is severe hemolysis associated with hemoglobinemia,hemoglobinuria and shock.[slideshare.net]

  • Chediak Higashi Syndrome

    Two of the patients, both with histologic and clinical evidence of the accelerated (infiltrative) phase of the syndrome, had intermittent hypersplenism manifest by splenomegaly[nejm.org] In addition to the albinism and bleeding diathesis, individuals with HPS2 also have congenital neutropenia, a recurrent pattern of severe bacterial infections, and pulmonary[ncbi.nlm.nih.gov] Splenomegaly was also present 6 cm below costal margin. Her gait was normal.[omicsgroup.org]

  • Platelet-Type Bleeding Disorder 17

    We describe here a rare case of GPS with myelofibrosis and splenomegaly indicating extramedullary hematopoiesis.[ncbi.nlm.nih.gov] Abstract The gray platelet syndrome (GPS) is a rare congenital platelet disorder characterized by mild to moderate bleeding diathesis, macrothrombocytopenia and lack of azurophilic[ncbi.nlm.nih.gov]

  • HIV-induced Thrombocytopenia

    […] significant splenomegaly disseminated intravascular coagulation (DIC) positive fibrin split products, hypofibrinogenemia aplastic or hypoplastic marrow absent or reduced[meducator3.net] […] anomalies Varies depending on primary abnormality Often asymptomatic when there is no bleeding diathesis Disseminated intravascular coagulation Severe Acute illness; bleeding[aafp.org] Lymphadenopathy and splenomegaly Lymphadenopathy and splenomegaly are commonly seen in association with HIV infection, particularly with acute infection.[hivmanagement.ashm.org.au]

  • Noonan Syndrome-Like Disorder with Juvenile Myelomonocytic Leukemia

    A case of splenomegaly in CBL syndrome.[eunetworkadultadhd.com] Bleeding diathesis is present in as many as half of all patients with Noonan syndrome.[misc.medscape.com] Intervention with chemotherapy is typically only indicated for CBL patients who become symptomatic (splenomegaly, failure to thrive, recurrent infections, etc.).[hematology.org]

  • Polycythemia Neonatorum

    (D73.81) primary splenic neutropenia (D73.81) splenitis, splenomegaly in late syphilis (A52.79) splenitis, splenomegaly in tuberculosis (A18.85) splenomegaly NOS (R16.1)[gotnpi.com] […] excavatum), cryptorchidism, intellectual disability (mental retardation), bleeding diathesis, and lymphedema (puffy hands and feet); cardiac defects: pulmonic stenosis and[brainscape.com] Neutrophilia, thrombocytopenia, and splenomegaly are common. Manifestations include plethora, vertigo, headache, and thrombosis. erythremia[medical-dictionary.thefreedictionary.com]

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