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160 Possible Causes for Congenital Heart Disease, Syndactyly of Second and Third Toes

  • Smith Lemli Opitz Syndrome

    The malformations present were facial dysmorphisms, cleft palate, congenital heart disease, genitourinary abnormalities, and syndactyly of the toes.[] The limbs had syndactyly of second and third toes with short and stubby fingers (Figure 4) and simian crease.[] Congenital heart disease consisted of hypoplastic left heart, coronary sinus agenesis, ostium secundum and ostium primum defects, and a thickened septum primum.[]

  • Trisomy 18

    A prenatal diagnosis of ductal-dependent, complex congenital heart disease was made in a fetus with trisomy 18.[] Fifth finger over fourth Feet: Rocker bottom feet Syndactyly of second and third toes Thorax: Short sternum Small nipples Abdominal wall: Inguinal / umbilical hernia Meckel[] A retrospective chart review of patients with trisomy 18 and congenital heart disease from 2005 to 2017 was performed.[]

  • Ellis-Van Creveld Syndrome

    In 1940 Ellis and van Creveld (2) described 2 more patients with similar congenital anomalies who, in addition, had congenital heart disease.[] third toes and hallux valgus.[] heart disease.[]

  • Cutis Marmorata

    It is important to recognize possibly life-threatening conditions that may accompany this disease, such as arrhythmias, congenital heart disease and venous insufficiency.[] Syndactyly of the second and third toes and/or the third and fourth fingers or toes was commonly seen. All of the cases were sporadic.[] The second had postaxial polydactyly of hands and feet, cutaneous syndactyly of third and fourth right fingers and of second and third right toes without evident cutis marmorata[]

  • Hemimelia

    Congenital heart disease has not been reported with TH-SHFM.[] There was associated lobster hand in a case, bilateral hand polydactyly in another case and syndactyly between second and third toes of the affected foot in one patient (Table[] Lethal congenital cardiac malformations have been described with “Tibial Hemimelia-Polydactyly syndrome”, an entity similar but distinct from TH-SHFM.[]

  • Dubowitz Syndrome

    For example, echocardiography is needed in the setting of congenital heart diseases (CHDs), whereas a complete laboratory workup with an immunological profile in case frequent[] The orthopedic manifestations of this condition primarily involve the hands and feet with brachyclinodactyly of the fifth finger and syndactyly of the second and third toes[] Syndactyly of the second and third toes is also frequently seen. Neurological anomalies have also been reported ( 11 ).[]

  • Adams-Oliver Syndrome

    heart disease, microcephaly, epilepsy, mental retardation, arrhinencephaly, hydrocephaly, anatomic bronchial anomalies, and renal anomalies.[] Note severe aplasia cutis congenita (A, B) with scalpand skull defects, limbs anomalies with brachydactyly of toes, bilateralcutaneous syndactyly of second and third toes,[] Apart from transverse limb defects, syndactyly, most commonly of second and third toes, can also be observed.[]

  • Craniofrontonasal Dysplasia

    heart disease NGS panel CHD7, ELN, GATA4, GATA6, GDF1, JAG1, NKX2-5, NKX2-6, NOTCH1, NOTCH2, NR2F2, TAB2, TBX1, TBX20, TBX5, ZIC3 Del Dup NGS Connective tissue disorder NGS[] Great toes were broad, and there was partial syndactyly of second, third and fourth toes bilaterally. Clinodactyly of both the fifth toe was obvious [Figure 1c] .[] ECEL1, ERBB3, FBN2, GLDN, GLE1, LGI4, LMNA, MUSK, MYBPC1, MYH3, MYH8, NALCN, NEK9, PIEZO2, PIP5K1C, RAPSN, TNNI2, TNNT3, TPM2, VIPAS39, VPS33B, ZBTB42, ZMPSTE24 Del Dup NGS Congenital[]

  • Syndactyly

    heart disease amongst others.[] […] of the second and third toes.[] "Congenital Heart Disease in the Adult." In Harrison's Principles of Internal Medicine, edited by Anthony S. Fauci, et al. New York: McGraw-Hill, 1997.[]

  • Cerebro-Costo-Mandibular Syndrome

    Miscellaneous findings - Congenital heart disease (septal defects), a horseshoe kidney, hearing loss, hypoplasia of the elbows and the clavicle and hypospadias are other notable[] […] between the second and third toes.[] Clinical Problems (Listed): HEENT - cleft palate, conductive hearing loss, glossoptosis, high arched palate, micrognathia Cardiac - congenital heart disease Respiratory -[]

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